Jieruo Gu
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View article: Clinical updates of JAK inhibitors in cutaneous granulomatous diseases
Clinical updates of JAK inhibitors in cutaneous granulomatous diseases Open
Cutaneous granulomatous diseases, characterized by persistent granuloma formation, often exhibit chronic and relapsing courses that are challenging to manage with conventional therapies. The Janus kinase (JAK)–signal transducer and activat…
View article: Regulatory role of POSTN in keloid pathogenesis
Regulatory role of POSTN in keloid pathogenesis Open
Keloids are an inflammatory cutaneous condition, which are characterized by fibroproliferative overgrowth of the skin. Although keloids are not life‑threatening, their incidence and recurrence are relatively high, thus decreasing the quali…
View article: Correction of breast deformities after breast-conserving surgery in Chinese women with breast cancer: a narrative review
Correction of breast deformities after breast-conserving surgery in Chinese women with breast cancer: a narrative review Open
Breast-conserving therapy (BCT) is a key treatment option for early-stage breast cancer, balancing oncologic control with cosmetic outcomes. However, postoperative breast deformities occur in approximately 25% to 30% of cases, significantl…
View article: Smart Glasses for Older Adults With Cognitive Impairment: A Scoping Review
Smart Glasses for Older Adults With Cognitive Impairment: A Scoping Review Open
View article: Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses Revealed Altered Local Spontaneous Neural Activities in Ankylosing Spondylitis
Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses Revealed Altered Local Spontaneous Neural Activities in Ankylosing Spondylitis Open
The fALFF and ReHo analyses consistently revealed significantly altered local spontaneous neural activities in AS patients, especially in the DMN, SN and FPN, comprising the triple network model. The slow-4 band might be more sensitive to …
View article: Global disease and economic burden of main mycobacterial infections in the working-age population from 1990 to 2021 with a forecast to 2045
Global disease and economic burden of main mycobacterial infections in the working-age population from 1990 to 2021 with a forecast to 2045 Open
Background: Mycobacterial infections such as tuberculosis and leprosy pose significant global health challenges, particularly in impoverished regions. These diseases not only cause severe physical symptoms but also lead to psychological an…
View article: Feature Extraction and Automatic Recognition Model Construction for Head Back Posture During the Parturition Process in Dairy Cows
Feature Extraction and Automatic Recognition Model Construction for Head Back Posture During the Parturition Process in Dairy Cows Open
The ‘head back’ posture is a pronounced and significant behavioral trait during bovine parturition, commonly interpreted as a natural response to the pain associated with parturition. Leveraging computer vision technology for real-time mon…
View article: Urgent need for inclusion of male infertility in global health strategies: insights from the GBD 2021 Study
Urgent need for inclusion of male infertility in global health strategies: insights from the GBD 2021 Study Open
This study examines the global burden and prevalence of male infertility using data from the Global Burden of Disease Study 2021 (GBD 2021 Study), encompassing 204 countries from 1990 to 2021. By analyzing disability-adjusted life years (D…
View article: Artificial intelligence-based prediction of organ involvement in Sjogren’s syndrome using labial gland biopsy whole-slide images
Artificial intelligence-based prediction of organ involvement in Sjogren’s syndrome using labial gland biopsy whole-slide images Open
View article: Immunophenotypic Profiling Reveals Circulating Lymphocyte Dysregulation in Primary Sjögren's Syndrome
Immunophenotypic Profiling Reveals Circulating Lymphocyte Dysregulation in Primary Sjögren's Syndrome Open
Objectives To investigate peripheral T and B cell subset alterations in primary Sjögren's syndrome (pSS) and their associations with disease activity (ESSDAI). Methods This study enrolled 43 patients with pSS and 46 healthy controls (HCs).…
View article: Facial Fat Necrosis After Autologous Fat Grafting Caused by Cellulitis: A Case Report
Facial Fat Necrosis After Autologous Fat Grafting Caused by Cellulitis: A Case Report Open
Autologous fat grafting is a widely used soft tissue filling technique for facial rejuvenation, favored for its high biocompatibility and long-lasting effects. However, the long-term risk of infection due to alterations in local tissue str…
View article: Proteomics signatures associated with hip arthropathy in ankylosing spondylitis
Proteomics signatures associated with hip arthropathy in ankylosing spondylitis Open
Objective Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the axial skeleton and peripheral joints, with hip arthropathy representing a severe complication that critically impairs mobility. While persisten…
View article: Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis
Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis Open
View article: The Global Burden of Atopic Dermatitis in Elderly Populations: Trends, Disparities, and Future Projections
The Global Burden of Atopic Dermatitis in Elderly Populations: Trends, Disparities, and Future Projections Open
Background: Atopic dermatitis (AD) is a common chronic inflammatory skin disease often affecting infants. However, its significance in adult populations is increasingly recognized. Notably, its prevalence and impact among elderly individua…
View article: Evaluating the performance of large language models in health education for patients with ankylosing spondylitis/spondyloarthritis: a cross-sectional, single-blind study in China
Evaluating the performance of large language models in health education for patients with ankylosing spondylitis/spondyloarthritis: a cross-sectional, single-blind study in China Open
Objectives To evaluate the potential of large language models (LLMs) in health education for patients with ankylosing spondylitis (AS)/spondyloarthritis (SpA), focusing on the accuracy of information transmission, patient acceptance and pe…
View article: A study on the correlation between hyperuricemia and lifestyle and dietary habits
A study on the correlation between hyperuricemia and lifestyle and dietary habits Open
This study aimed to compare whether differences in lifestyle and dietary habits have an impact on hyperuricemia and to provide a reliable basis for the health management of citizens in our city. A total of 10,883 subjects who did not suffe…
View article: Study on the commercial standard of specification grades of Citri Sarcodactylis Fructus from Guangdong
Study on the commercial standard of specification grades of Citri Sarcodactylis Fructus from Guangdong Open
View article: Comparative Study of Preservation Methods for Berberis Lycium Juice: A Laboratory Approach at Shaheed Benazir Bhutto University, Sheringal, Dir Upper, Pakistan
Comparative Study of Preservation Methods for Berberis Lycium Juice: A Laboratory Approach at Shaheed Benazir Bhutto University, Sheringal, Dir Upper, Pakistan Open
This study examines the effects of diverse preservation techniques on the shelf life, nutritional importance, microbiological safety, and sensory behavior of Berberis lycium juice. These techniques consist of vacuum sealing, freezing, refr…
View article: Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus
Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus Open
View article: Global burden of bacterial skin diseases from 1990 to 2045: An analysis based on Global Burden Disease data
Global burden of bacterial skin diseases from 1990 to 2045: An analysis based on Global Burden Disease data Open
Background The global burden of bacterial skin diseases has not been well evaluated.Objective We aimed to describe the burden and trend of bacterial skin diseases, to explore potential associated factors, and to predict the burden up to 20…
View article: A phase 3, randomized, double-blind, active-controlled clinical trial to compare BAT1806/BIIB800, a tocilizumab biosimilar, with tocilizumab reference product in participants with moderate-to-severe rheumatoid arthritis with inadequate response to methotrexate: treatment period 2 analysis (week 24 to week 48)
A phase 3, randomized, double-blind, active-controlled clinical trial to compare BAT1806/BIIB800, a tocilizumab biosimilar, with tocilizumab reference product in participants with moderate-to-severe rheumatoid arthritis with inadequate response to methotrexate: treatment period 2 analysis (week 24 to week 48) Open
View article: Association between asymptomatic hyperuricemia and risk of arthritis, findings from a US National Survey 2007–2018
Association between asymptomatic hyperuricemia and risk of arthritis, findings from a US National Survey 2007–2018 Open
Background Arthritis is thought to be closely related to serum uric acid. The study aims to assess the association between asymptomatic hyperuricemia (AH) and arthritis. Methods A multistage, stratified cluster was used to conduct a cross-…
View article: Safety and efficacy of peficitinib in Asian patients with rheumatoid arthritis who had an inadequate response or intolerance to methotrexate: results of a multicenter, randomized, double-blind, placebo-controlled phase 3 study
Safety and efficacy of peficitinib in Asian patients with rheumatoid arthritis who had an inadequate response or intolerance to methotrexate: results of a multicenter, randomized, double-blind, placebo-controlled phase 3 study Open
Astellas Pharma.
View article: Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy
Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy Open
Significance Statement Genome-wide association studies have identified nearly 20 IgA nephropathy susceptibility loci. However, most nonsynonymous coding variants, particularly ones that occur rarely or at a low frequency, have not been wel…
View article: Safety and Effectiveness of Baricitinib in Chinese Patients with Moderate-to-Severe Rheumatoid Arthritis: 24-Week Results from a Post-Marketing Safety Study
Safety and Effectiveness of Baricitinib in Chinese Patients with Moderate-to-Severe Rheumatoid Arthritis: 24-Week Results from a Post-Marketing Safety Study Open
EU PAS Register: EUPAS34213.
View article: Diagnostic biomarkers and potential treatment targets for Ankylosing Spondylitis
Diagnostic biomarkers and potential treatment targets for Ankylosing Spondylitis Open
Background Ankylosing spondylitis (AS) is a chronic autoimmune disease that primarily affects the axial joints. Immune cells play a key role in the pathogenesis of AS. This study integrated bioinformatics methods with experimental validati…
View article: A prognostic model for systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study
A prognostic model for systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study Open
Background Pulmonary arterial hypertension is a major cause of death in systemic lupus erythematosus, but there are no tools specialized for predicting survival in systemic lupus erythematosus-associated pulmonary arterial hypertension. Re…
View article: Improve quality of patient care for systemic lupus erythematosus in China by enhancing the construction of Centers of Excellence
Improve quality of patient care for systemic lupus erythematosus in China by enhancing the construction of Centers of Excellence Open
View article: The diagnostic value of morphological features of fat deposition of sacroiliac joint steatosis in axial spondyloarthritis
The diagnostic value of morphological features of fat deposition of sacroiliac joint steatosis in axial spondyloarthritis Open
Background Findings of fatty lesions in the context of other imaging manifestations, especially bone marrow edema and erosions can effectively assist in the diagnosis of axSpA. Chemical shift-encoded MRI is a sequence which allows for the …
View article: The study of the effect of <scp>HLA‐B27</scp> on <scp>THP</scp>‐1 monocytic cells survival and its mechanism
The study of the effect of <span>HLA‐B27</span> on <span>THP</span>‐1 monocytic cells survival and its mechanism Open
Objective Previous studies have shown that human leukocyte antigen (HLA)‐B27 induces the accumulation of unfolded proteins in the endoplasmic reticulum (ER) to cause ER stress, resulting in the unfold protein response (UPR), apoptosis and …