Jiewei Chen
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View article: Comparative analysis of scaffold-free tissue-engineered cartilage derived from different seed cells: <i>in vitro</i> and <i>in vivo</i> studies
Comparative analysis of scaffold-free tissue-engineered cartilage derived from different seed cells: <i>in vitro</i> and <i>in vivo</i> studies Open
Objective The development of cartilage tissue engineering offers a promising strategy for effective cartilage regeneration. This study aims to synthesize scaffold-free tissue-engineered cartilage (TEC) using articular chondrocytes (ACs), c…
View article: A clinical-grade universal foundation model for intraoperative pathology
A clinical-grade universal foundation model for intraoperative pathology Open
Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant …
View article: A Multicenter Study on Unnecessary Rebiopsies in CT‐Guided Percutaneous Transthoracic Needle Biopsy of Pulmonary Lesions
A Multicenter Study on Unnecessary Rebiopsies in CT‐Guided Percutaneous Transthoracic Needle Biopsy of Pulmonary Lesions Open
Background and Objective Computed tomography‐guided percutaneous transthoracic needle biopsy of pulmonary lesions (PTNBP) is widely used for diagnosing and managing lung cancer. However, rebiopsies are often required due to insufficient sp…
View article: Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection
Phase separation of ERCC6L2–CtIP regulates the extent of DNA end resection Open
View article: Superior diagnostic performance of Grocott methenamine silver staining in pulmonary cryptococcosis: a multicenter, large-sample cohort study
Superior diagnostic performance of Grocott methenamine silver staining in pulmonary cryptococcosis: a multicenter, large-sample cohort study Open
Introduction In the histopathological diagnosis of pulmonary fungal infections, particularly pulmonary cryptococcosis, the diagnostic performance of different staining techniques varies significantly, often confounding pathologists. This s…
View article: CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue Open
CD4+ TRM17 cells are the predominant source of IL-17A in SpA synovial tissue. TCR stimulation is essential for the secretion of IL-17A by CD4+TRM17-like cells. The epigenetic regulator bromodomain-containing protein 1 (BRD1) contributes to…
View article: Hip arthroscope-assisted percutaneous reduction and fixation of displaced subcapital femoral neck fracture
Hip arthroscope-assisted percutaneous reduction and fixation of displaced subcapital femoral neck fracture Open
Reduction quality is associated with fracture prognosis. Displaced subcapital femoral neck fracture has highest possibility of avascular necrosis of femoral head and non-union among the femoral neck fractures, which commonly necessitate re…
View article: Case report: Free autologous costal cartilage transplantation for osteochondral lesions of the talus: three cases with 2–5 years follow-up
Case report: Free autologous costal cartilage transplantation for osteochondral lesions of the talus: three cases with 2–5 years follow-up Open
Background Osteochondral lesions of the talus (OLT) is a common and clinically challenging condition with no consensus on the optimal treatment. The prospective case series aim to evaluate the feasibility and clinical outcomes of free auto…
View article: Efficacy and prognosis biomarker of locally advanced ESCC patients treated with neoadjuvant chemotherapy and anti-PD-1 immunotherapy
Efficacy and prognosis biomarker of locally advanced ESCC patients treated with neoadjuvant chemotherapy and anti-PD-1 immunotherapy Open
Introduction Immunotherapy has rapidly advanced in tumor treatment. In esophageal squamous cell carcinoma (ESCC), its use in neoadjuvant therapy has shown promising results. Several phase III clinical trials have confirmed that immunodetec…
View article: METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma
METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma Open
View article: CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue
CD4+ tissue-resident memory Th17 cells are a major source of IL-17A in Spondyloarthritis synovial tissue Open
Objectives Interleukin (IL)-17A is a key driver of Spondyloarthritis (SpA) joint pathology. We aimed to identify its cellular source in synovial tissue from patients with two forms of SpA namely Axial SpA (AxSpA) and Psoriatic arthritis (P…
View article: AxSpA joint tissue is characterised by HLA-DR<sup>+</sup>tissue resident memory (TRM) and killer cell immunoglobulin-like receptor (KIR)<sup>+</sup>CD8<sup>+</sup>T cell subsets
AxSpA joint tissue is characterised by HLA-DR<sup>+</sup>tissue resident memory (TRM) and killer cell immunoglobulin-like receptor (KIR)<sup>+</sup>CD8<sup>+</sup>T cell subsets Open
Objective Axial Spondyloarthritis (AxSpA) is a common inflammatory arthritis with HLA-B*27 as the major genetic risk. Recent discoveries of AxSpA-specific T cell receptor (TCR) motifs and the self and bacterial peptides that they recognize…
View article: Detection of varicella-zoster virus in saliva and plasma of patients with typical and atypical herpes zoster
Detection of varicella-zoster virus in saliva and plasma of patients with typical and atypical herpes zoster Open
View article: Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy
Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy Open
RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in colorectal cancer (CRC) are still…
View article: Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma
Dual specific phosphatase 4 suppresses ferroptosis and enhances sorafenib resistance in hepatocellular carcinoma Open
Our findings introduce DUSP4 as a negative regulator of sorafenib-induced ferroptosis. This discovery opens new avenues for the development of ferroptosis-based therapeutic strategies tailored for HCC treatment.
View article: NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1
NEIL1 drives the initiation of colorectal cancer through transcriptional regulation of COL17A1 Open
Deficiency of DNA repair pathways drives the development of colorectal cancer. However, the role of the base excision repair (BER) pathway in colorectal cancer initiation remains unclear. This study shows that Nei-like DNA glycosylase 1 (N…
View article: Integrated genetic and epigenetic analysis reveals DNA repair alterations in multifocal hepatocellular carcinoma
Integrated genetic and epigenetic analysis reveals DNA repair alterations in multifocal hepatocellular carcinoma Open
View article: <scp>TRIM29</scp> acts as a potential senescence suppressor with epigenetic activation in nasopharyngeal carcinoma
<span>TRIM29</span> acts as a potential senescence suppressor with epigenetic activation in nasopharyngeal carcinoma Open
Epigenetic alterations marked by DNA methylation are frequent events during the early development of nasopharyngeal carcinoma (NPC). We identified that TRIM29 is hypomethylated and overexpressed in NPC cell lines and tissues. TRIM29 silenc…
View article: Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin
Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin Open
View article: Body mass index, as a novel predictor of hepatocellular carcinoma patients treated with Anti-PD-1 immunotherapy
Body mass index, as a novel predictor of hepatocellular carcinoma patients treated with Anti-PD-1 immunotherapy Open
Immunocheckpoint inhibitors have shown significant efficacy in the treatment of hepatocellular carcinoma (HCC), but there are individual differences. The aim of this study was to explore body mass index (BMI) as a predictor of anti-PD-1 ef…
View article: Grocott Methenamine Silver Staining Is the Optimal Approach to Histological Diagnosis of Pulmonary Cryptococcosis
Grocott Methenamine Silver Staining Is the Optimal Approach to Histological Diagnosis of Pulmonary Cryptococcosis Open
Background Histological staining methods for Cryptococcus identification vary in accuracy. This study aimed to investigate the clinical value of Grocott methenamine silver (GMS), periodic acid-Schiff (PAS), and Alcian blue (AB) staining in…
View article: Clinicopathological and prognostic significance of Trophinin-associated protein expression and its relationship with P53 status in pulmonary sarcomatoid carcinoma: A retrospective multicenter study based on bioinformatic analysis
Clinicopathological and prognostic significance of Trophinin-associated protein expression and its relationship with P53 status in pulmonary sarcomatoid carcinoma: A retrospective multicenter study based on bioinformatic analysis Open
Trophinin-associated protein (TROAP) levels and P53 status have been used to predict the prognosis of various human tumors. However, the clinicopathological and prognostic significance of TROAP expression and P53 status in pulmonary sarcom…
View article: Combining serum inflammation indexes at baseline and post treatment could predict pathological efficacy to anti‑PD‑1 combined with neoadjuvant chemotherapy in esophageal squamous cell carcinoma
Combining serum inflammation indexes at baseline and post treatment could predict pathological efficacy to anti‑PD‑1 combined with neoadjuvant chemotherapy in esophageal squamous cell carcinoma Open
Background The neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) have been used to predict therapeutic response in different tumors. H…
View article: Additional file 3 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin
Additional file 3 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin Open
Additional file 3. Table S2. Expression change of 17 genes in paired breast cancers and their metastases
View article: Additional file 4 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin
Additional file 4 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin Open
Additional file 4. Table S3. Correlation between protein and mRNA levels of 9 candidate genes.
View article: Additional file 5 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin
Additional file 5 of Matrix Gla protein (MGP), GATA3, and TRPS1: a novel diagnostic panel to determine breast origin Open
Additional file 5. Table S4. The immunoreactive scores of GATA3, TRPS1 and MGP in 1201 cases of breast cancer.
View article: Cleavage factor Im 25 as a potential biomarker for prognosis of colorectal cancer
Cleavage factor Im 25 as a potential biomarker for prognosis of colorectal cancer Open
Polyadenylation; survival analysis; colorectal cancer (CRC); CFIm25.
View article: Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures
Pan-Cancer Analysis of PARP1 Alterations as Biomarkers in the Prediction of Immunotherapeutic Effects and the Association of Its Expression Levels and Immunotherapy Signatures Open
Background Poly (ADP-ribose) polymerases-1 (PARP1) alterations are associated with PARP1 inhibitor resistance, regulating the function of Treg cells and PDL1 expression in tumor cells, and high PARP1 expression is significantly associated …
View article: Prognostic Model for the Risk Stratification of Early and Late Recurrence in Hepatitis B Virus-Related Small Hepatocellular Carcinoma Patients with Global Histone Modifications
Prognostic Model for the Risk Stratification of Early and Late Recurrence in Hepatitis B Virus-Related Small Hepatocellular Carcinoma Patients with Global Histone Modifications Open
Global histone modifications in tumor and adjacent liver tissues are novel predictors of early and late recurrence, respectively, in HBV-related small HCC patients.
View article: Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity
Correction to: KIFC1 is activated by TCF-4 and promotes hepatocellular carcinoma pathogenesis by regulating HMGA1 transcriptional activity Open
An amendment to this paper has been published and can be accessed via the original article.