Juan Tang
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View article: Integrated analysis of N-glycosylation and Alzheimer’s disease: identifying key biomarkers and mechanisms
Integrated analysis of N-glycosylation and Alzheimer’s disease: identifying key biomarkers and mechanisms Open
Background Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly, imposing a significant societal burden. Current therapeutic approaches primarily address symptoms, underscoring the critical need to elucidate its …
View article: Vitamin D receptor modulates autophagy via miR-20a-5p/ATG16L1 axis to alleviate lipopolysaccharide-induced acute kidney injury
Vitamin D receptor modulates autophagy via miR-20a-5p/ATG16L1 axis to alleviate lipopolysaccharide-induced acute kidney injury Open
Sepsis-associated acute kidney injury (S-AKI) is a critical and life-threatening clinical syndrome characterized by intricate pathophysiological mechanisms and lack of effective therapeutic strategies. Our previous investigations in a diab…
View article: Vegetation dynamics along an urban–rural gradient in the Yangtze River Delta: patterns, mechanisms, and scenario projections using a mixed-cell cellular automata (MCCA) framework
Vegetation dynamics along an urban–rural gradient in the Yangtze River Delta: patterns, mechanisms, and scenario projections using a mixed-cell cellular automata (MCCA) framework Open
Understanding how the urban–rural gradient modulates vegetation dynamics under climate change and rapid urbanization is crucial for precise ecological management. However, existing research often uses coarse gradient classifications, while…
View article: Synthesis and Evaluation of Diphenylpyrazine Cyclic Amine Derivatives as IP Receptor Agonists
Synthesis and Evaluation of Diphenylpyrazine Cyclic Amine Derivatives as IP Receptor Agonists Open
Pulmonary arterial hypertension (PAH) is a severe, progressive condition with limited treatments. This study focuses on developing novel IP receptor agonists for PAH therapy. By modifying MRE-269, a highly selective IP receptor agonist, we…
View article: Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus-induced urethral strictures
Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus-induced urethral strictures Open
Male genital lichen sclerosus-induced urethral stricture is a chronic inflammatory disease with significant microbiota dysbiosis. However, dysbiosis inside lesion tissue and its correlation with gene expression in male genital lichen scler…
View article: Deep Learning‐Based Prediction of High‐Risk Gastroesophageal Varices Using Two‐Dimensional Shear Wave Elastography
Deep Learning‐Based Prediction of High‐Risk Gastroesophageal Varices Using Two‐Dimensional Shear Wave Elastography Open
Aims Bleeding from gastroesophageal varices (GEV) is a medical emergency associated with high mortality. We aim to construct an artificial intelligence‐based model of two‐dimensional shear wave elastography (2D‐SWE) of the liver and spleen…
View article: Profiles and kinetics of PgRNA and clinical characteristics in pregnant, postpartum, and non-pregnant women with chronic HBV infection
Profiles and kinetics of PgRNA and clinical characteristics in pregnant, postpartum, and non-pregnant women with chronic HBV infection Open
View article: Evaluation of the therapeutic effect of estrogen replacement therapy combined with autologous serum therapy in controlling severe dry eye disease in perimenopausal women
Evaluation of the therapeutic effect of estrogen replacement therapy combined with autologous serum therapy in controlling severe dry eye disease in perimenopausal women Open
View article: Association between Lyn tyrosine kinase and renal injury in patients with systemic lupus erythematosus
Association between Lyn tyrosine kinase and renal injury in patients with systemic lupus erythematosus Open
The protein kinase Lyn was inversely associated with disease activity, albuminuria level and renal pathology activity in SLE and may be a promising biomarker for assessing LN disease activity.
View article: Exercise Related microRNAs in <i>C. elegans</i> Regulate Calcium Homeostasis and Mitochondrial Dynamics: Conserved pathways, Divergent mircoRNAs
Exercise Related microRNAs in <i>C. elegans</i> Regulate Calcium Homeostasis and Mitochondrial Dynamics: Conserved pathways, Divergent mircoRNAs Open
Exercise can help mitigate age-related muscle atrophy, promoting mitochondrial function, Ca 2+ homeostasis and regulating gene expression. MicroRNAs (miRs) are crucial post-transcriptional regulators of gene expression, fine tuning protein…
View article: Pulmonary fibrosis: from mechanisms to therapies
Pulmonary fibrosis: from mechanisms to therapies Open
Pulmonary fibrosis (PF) is a chronic, progressive interstitial lung disease characterized by excessive deposition of extracellular matrix (ECM) and abnormal fibroblast proliferation, which is mainly caused by air pollution, smoking, aging,…
View article: Kaili sour soup in alleviation of hepatic steatosis in rats via lycopene route: an experimental study
Kaili sour soup in alleviation of hepatic steatosis in rats via lycopene route: an experimental study Open
KSS ameliorated abnormal lipid metabolism in patients with NAFLD. Lycopene was the major component of KSS, and it affected estrogen signaling and the expression of lipid metabolism molecules. In short, both KSS and LYC could change lipid m…
View article: A study on pregenomic RNA and factors in the pregnant and postpartum women with chronic HBV infection based on real world
A study on pregenomic RNA and factors in the pregnant and postpartum women with chronic HBV infection based on real world Open
Introduction Most studies have focused on mother-to-child transmission and postpartum hepatitis flares. We aimed to evaluate the expression profile of pregenomic RNA (pgRNA) and its associated factors in patients with chronic HBV infection…
View article: Modulation of Th17/Treg Balance by Total Flavonoids from Semen Cuscutae through PGRMC2 in a Diminished Ovarian Reserve Rat Model
Modulation of Th17/Treg Balance by Total Flavonoids from Semen Cuscutae through PGRMC2 in a Diminished Ovarian Reserve Rat Model Open
View article: Impact of land use types on soil microbial community structure and functional structure in Baihualing Village, China
Impact of land use types on soil microbial community structure and functional structure in Baihualing Village, China Open
Soil microorganisms play important ecological roles, and land-use practices have profoundly altered their composition, diversity and functions. However, most existing research has been conducted in areas with high levels of anthropogenic i…
View article: Decoding Tianjin: How Does Urban Form Shape the Diurnal Cycle of Surface Temperature?
Decoding Tianjin: How Does Urban Form Shape the Diurnal Cycle of Surface Temperature? Open
In the context of global climate change and the increasing severity of the urban heat island effect, it is particularly important to study the spatial variation mechanism of urban land surface temperature (LST). The LST data provided by EC…
View article: Patterns and Mechanisms of Legume Responses to Nitrogen Enrichment: A Global Meta-Analysis
Patterns and Mechanisms of Legume Responses to Nitrogen Enrichment: A Global Meta-Analysis Open
Nitrogen (N), while the most abundant element in the atmosphere, is an essential soil nutrient that limits plant growth. Leguminous plants naturally possess the ability to fix atmospheric nitrogen through symbiotic relationships with rhizo…
View article: Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of disease study 2019
Global, regional, and national time trends in ischaemic heart disease incidence over three decades (1990–2019): an age-period-cohort analysis of the global burden of disease study 2019 Open
Introduction To assess the prevailing trends in the incidence of ischemic heart disease (IHD) across 204 countries and territories from 1990 to 2019, and to elucidate their correlations with age, period, and birth cohort, a comprehensive a…
View article: Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus- induced urethral strictures
Multi-omics analysis reveals the host-microbe interactions on the dysbiosis of tissue microbiota in male genital lichen sclerosus- induced urethral strictures Open
Background Male genital lichen sclerosus-induced urethral strictures (MGLSc-US) is a chronic inflammatory disease with significant microbiota dysbiosis. The impact of this dysbiosis on disease progression and gene expression in MGLSc lesio…
View article: Differences in global, regional, and national time trends in disability-adjusted life years for atrial fibrillation and flutter, 1990–2019: an age-period-cohort analysis from the 2019 global burden of disease study
Differences in global, regional, and national time trends in disability-adjusted life years for atrial fibrillation and flutter, 1990–2019: an age-period-cohort analysis from the 2019 global burden of disease study Open
Background Atrial fibrillation and flutter, collectively referred to as AF/AFL, pose substantial public health challenges across nations of different economic statuses. Abjective This research is intended to assess the discrepancies in glo…
View article: Involvement of the cytochrome P450 genes CYP6DW3 and CYP4C64 in afidopyropen resistance in Bemisia tabaci Mediterranean (Q biotype)
Involvement of the cytochrome P450 genes CYP6DW3 and CYP4C64 in afidopyropen resistance in Bemisia tabaci Mediterranean (Q biotype) Open
The tobacco whitefly, Bemisia tabaci, is a notorious pest affecting various crops globally, and it exhibits high levels of resistance to various insecticides. Afidopyropen is a recently commercialized pyropene insecticide for B. tabaci con…
View article: [Risk factors for pancreatitis after endoscopic retrograde cholangiopancreatography in children].
[Risk factors for pancreatitis after endoscopic retrograde cholangiopancreatography in children]. Open
With the increasing application of ERCP in children with pancreaticobiliary diseases, it is important to select an appropriate intubation technique during surgery to avoid blindly entering the guidewire into the pancreatic duct and reduce …
View article: Identification of key genes as potential diagnostic biomarkers in sepsis by bioinformatics analysis
Identification of key genes as potential diagnostic biomarkers in sepsis by bioinformatics analysis Open
Background Sepsis, an infection-triggered inflammatory syndrome, poses a global clinical challenge with limited therapeutic options. Our study is designed to identify potential diagnostic biomarkers of sepsis onset in critically ill patien…
View article: The relationship between potassium levels and 28-day mortality in sepsis patients: Secondary data analysis using the MIMIC-IV database
The relationship between potassium levels and 28-day mortality in sepsis patients: Secondary data analysis using the MIMIC-IV database Open
View article: Analyzing the changing trend of corneal biomechanical properties under different influencing factors in T2DM patients
Analyzing the changing trend of corneal biomechanical properties under different influencing factors in T2DM patients Open
View article: Causal relationship between particulate matter 2.5 and infectious diseases: A two-sample Mendelian randomization study
Causal relationship between particulate matter 2.5 and infectious diseases: A two-sample Mendelian randomization study Open
View article: Upregulation of the protein kinase Lyn is associated with renal injury in type 2 diabetes patients
Upregulation of the protein kinase Lyn is associated with renal injury in type 2 diabetes patients Open
Lyn levels in PBMCs exhibited a positive correlation with the severity of albuminuria, renal tubular damage, and inflammatory responses. Hence, Lyn may be a compelling candidate for predicting albuminuria levels in diabetes.
View article: [Neutrophil-lymphocyte and platelet-lymphocyte ratios for assessing disease activity in patients with rheumatoid arthritis receiving tofacitinib treatment].
[Neutrophil-lymphocyte and platelet-lymphocyte ratios for assessing disease activity in patients with rheumatoid arthritis receiving tofacitinib treatment]. Open
NLR and PLR can be useful biomarkers for assessing disease activity in RA patients treated with tofacitinib.
View article: The correlation of hemoglobin and 28-day mortality in septic patients: secondary data mining using the MIMIC-IV database
The correlation of hemoglobin and 28-day mortality in septic patients: secondary data mining using the MIMIC-IV database Open
View article: Deep learning radiomics for assessment of gastroesophageal varices in people with compensated advanced chronic liver disease
Deep learning radiomics for assessment of gastroesophageal varices in people with compensated advanced chronic liver disease Open
Objective: Bleeding from gastroesophageal varices (GEV) is a medical emergency associated with high mortality. We aim to construct an artificial intelligence-based model of two-dimensional shear wave elastography (2D-SWE) of the liver and …