Jiezhong Deng
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View article: Application of metagenomic next-generation sequencing in the precise and rapid diagnosis of spinal infections
Application of metagenomic next-generation sequencing in the precise and rapid diagnosis of spinal infections Open
Compared to conventional microbial culture, mNGS demonstrates superior diagnostic performance in spinal infections, with significantly higher pathogen detection rates and enhanced sensitivity, accuracy PPV and NPV. mNGS exhibits significan…
View article: Vitamin D and bone health: from physiological function to disease association
Vitamin D and bone health: from physiological function to disease association Open
View article: IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis
IL-19 suppresses Hippo signaling via modulating YAP1 phosphorylation in osteoarthritis Open
Introduction Osteoarthritis (OA) is one of the most prevalent chronic degenerative diseases, characterized by the progressive destruction of joints, which is primarily evidenced by alterations in the phenotype of chondrocytes, chondrocyte …
View article: Nonketotic hyperglycemic hemichorea: white shadows on CT and T1-weighted MRI
Nonketotic hyperglycemic hemichorea: white shadows on CT and T1-weighted MRI Open
View article: Biomechanical evaluation of various fixation strategies in oblique lumbar interbody fusion: a finite element analysis
Biomechanical evaluation of various fixation strategies in oblique lumbar interbody fusion: a finite element analysis Open
View article: K-rod Posterior Dynamic Stabilization Could Reduce Adjacent Segment Degeneration: A Mi nimum 5-Year Follow-up
K-rod Posterior Dynamic Stabilization Could Reduce Adjacent Segment Degeneration: A Mi nimum 5-Year Follow-up Open
Objective To evaluate the efficacy of posterior dynamic stabilization (PDS) in treating single-level lumbar degenerative disease and to examine its effect on first cephalad adjacent segment (FCAS) degeneration. Methods This retrospective s…
View article: Vitamin D inhibits apoptosis in THP-1 cells infected with mycobacterium tuberculosis through TNF signaling pathway
Vitamin D inhibits apoptosis in THP-1 cells infected with mycobacterium tuberculosis through TNF signaling pathway Open
Vitamin D (VD) has been extensively associated with the resistance against tuberculosis (TB); however, the mechanism underlying the reduction in TB susceptibility by VD remains uncertain. In our prior investigation, we discovered the relat…
View article: SplintR ligation-triggered <i>in-situ</i> rolling circle amplification on magnetic bead for accurate detection of circulating microRNAs
SplintR ligation-triggered <i>in-situ</i> rolling circle amplification on magnetic bead for accurate detection of circulating microRNAs Open
The circulating microRNAs (miRNAs), endogenous noncoding RNAs, post-transcriptionally participate in multiple processes during cell growth and development. Moreover, dysregulation of miRNAs expression is intricately associated with cancer.…
View article: Cartilage Intermediate Layer Protein‐1 Promotes Extracellular Matrix Degeneration via Interacting With <scp>CD47</scp>
Cartilage Intermediate Layer Protein‐1 Promotes Extracellular Matrix Degeneration via Interacting With <span>CD47</span> Open
Intervertebral Disc Degeneration (IDD) is a multifactorial result contributing to Low Back Pain (LBP) while Cartilage Intermediate Layer Protein‐1 (CILP‐1) is gradually up‐regulated along with IDD. Whether CILP‐1 acts in a direct role prom…
View article: Mycobacterium tuberculosis specific protein Rv1509 modulates osteoblast and osteoclast differentiation via TLR2 signaling
Mycobacterium tuberculosis specific protein Rv1509 modulates osteoblast and osteoclast differentiation via TLR2 signaling Open
View article: Vitamin D inhibits apoptosis in THP-1 cells infected with mycobacterium tuberculosis through TNF signaling pathway
Vitamin D inhibits apoptosis in THP-1 cells infected with mycobacterium tuberculosis through TNF signaling pathway Open
Vitamin D (VD) has been extensively associated with the resistance against tuberculosis (TB); however, the mechanism underlying the reduction in TB susceptibility by VD remains uncertain. In our prior investigation, we discovered the relat…
View article: The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis
The IRF1/GBP5 axis promotes osteoarthritis progression by activating chondrocyte pyroptosis Open
View article: Simultaneous Single-Position Oblique Lateral Interbody Fusion Combined With Unilateral Percutaneous Pedicle Screw Fixation for Single-Level Lumbar Tuberculosis: A 3-Year Retrospective Comparative Study
Simultaneous Single-Position Oblique Lateral Interbody Fusion Combined With Unilateral Percutaneous Pedicle Screw Fixation for Single-Level Lumbar Tuberculosis: A 3-Year Retrospective Comparative Study Open
Objective: To illustrate a simultaneous single-position oblique lateral interbody fusion (SPOLIF) combined with unilateral percutaneous pedicle screw fixation in treating single-level lumbar tuberculosis, compared with posterior-only appro…
View article: [Influence of reactive oxygen species responsive self-assembled nanomicelle loaded with pyroptosis inhibitor on full-thickness skin defects in diabetic rats].
[Influence of reactive oxygen species responsive self-assembled nanomicelle loaded with pyroptosis inhibitor on full-thickness skin defects in diabetic rats]. Open
Objective: To investigate the influence of reactive oxygen species (ROS) responsive self-assembled nanomicelle loaded with pyroptosis inhibitor on full-thickness skin defects in diabetic rats. Methods: Experimental research m…
View article: [<i>In situ</i> monitoring and regulation of local reactive oxygen species levels to promote wound repair].
[<i>In situ</i> monitoring and regulation of local reactive oxygen species levels to promote wound repair]. Open
Local oxidative stress and inflammatory response are the essential procedures in wound repair, which determine the progress, prognosis, and quality of wound repair. Reactive oxygen species is one of the important indexes reflecting oxidati…
View article: Connective Tissue Growth Factor From Periosteal Tartrate Acid Phosphatase-Positive Monocytes Direct Skeletal Stem Cell Renewal and Fate During Bone Healing
Connective Tissue Growth Factor From Periosteal Tartrate Acid Phosphatase-Positive Monocytes Direct Skeletal Stem Cell Renewal and Fate During Bone Healing Open
The periosteum is critical for bone healing. Studies have shown that the periosteum contains periosteal stem cells (PSCs) with multidirectional differentiation potential and self-renewal ability. PSCs are activated in early fracture healin…
View article: [A prospective randomized controlled study of the therapeutic effects of a self-developed novel low-temperature boric acid wet dressing on the face and neck wounds of patients with superficial burns].
[A prospective randomized controlled study of the therapeutic effects of a self-developed novel low-temperature boric acid wet dressing on the face and neck wounds of patients with superficial burns]. Open
Objective: To observe and explore the clinical therapeutic effects of a self-developed novel low-temperature boric acid wet dressing on the face and neck wounds of patients with superficial burns. Methods: A prospective rando…
View article: Vitamin D receptor activated by vitamin D administration alleviates <i>Mycobacterium tuberculosis</i> ‐induced bone destruction by inhibiting NFκB‐mediated aberrant osteoclastogenesis
Vitamin D receptor activated by vitamin D administration alleviates <i>Mycobacterium tuberculosis</i> ‐induced bone destruction by inhibiting NFκB‐mediated aberrant osteoclastogenesis Open
Clinically, bone destruction caused by Mycobacterium tuberculosis was serious especially in patients with vitamin D (VD) deficiency. However, the role of VD in M. tuberculosis ‐induced bone destruction remains clear. In this context, we in…
View article: Genomic analysis of hepatobiliary lithiasis associated cholangiocarcinoma revealed a distinct subtype feature
Genomic analysis of hepatobiliary lithiasis associated cholangiocarcinoma revealed a distinct subtype feature Open
View article: Clinical Efficacy of Three Surgical Approaches for the Treatment of Cervicothoracic Tuberculosis: A Multicenter Retrospective Study
Clinical Efficacy of Three Surgical Approaches for the Treatment of Cervicothoracic Tuberculosis: A Multicenter Retrospective Study Open
Objective To evaluate the efficacy of three surgical approaches for the treatment of cervicothoracic tuberculosis. Methods This is a multicenter retrospective study. We analyzed 74 patients with cervicothoracic tuberculosis who were treate…
View article: Anti-IFN-γ Antibody Promotes Osteoclastogenesis in Human Bone Marrow Monocyte-Derived Macrophages Co-Cultured with Tuberculosis-Activated Th1 Cells
Anti-IFN-γ Antibody Promotes Osteoclastogenesis in Human Bone Marrow Monocyte-Derived Macrophages Co-Cultured with Tuberculosis-Activated Th1 Cells Open
Background/Aims: Tuberculosis induces bone loss and activates Th1 cells that play an important role in the host defense of Bacille Calmette-Guérin tuberculosis vaccine. However, the role of tuberculosis-activated Th1 cells in differentiati…
View article: Microbial sensor for drug susceptibility testing of<i>Mycobacterium tuberculosis</i>
Microbial sensor for drug susceptibility testing of<i>Mycobacterium tuberculosis</i> Open
The overall detection result of the microbial sensor agreed well with that of the conventional LJ proportion method and takes less time than the existing phenotypic methods. In future studies, we will build an O2 electrode array…
View article: Development and evaluation of an efficient heterologous gene knock-in reporter system in Lactococcus lactis
Development and evaluation of an efficient heterologous gene knock-in reporter system in Lactococcus lactis Open
By using the system, the heterologous gene knocked-in clones are screened by colony phenotype change rather than by checking colonies individually. Our new knock-in reporter system provides an efficient method to create heterologous genes …