Jifang Sheng
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View article: Analysis of common treatment-related adverse events of donafenib and its correlation with efficacy: exploratory analysis of the ZGDH3 study
Analysis of common treatment-related adverse events of donafenib and its correlation with efficacy: exploratory analysis of the ZGDH3 study Open
View article: Short-term and long-term effects of anterior and posterior surgical approaches on plantar pressure distribution in patients with cervical spondylotic myelopathy
Short-term and long-term effects of anterior and posterior surgical approaches on plantar pressure distribution in patients with cervical spondylotic myelopathy Open
ACDF surgery provides faster and more sustained improvement in medial plantar pressure for CSM patients, correlating with its direct relief of ventral spinal cord compression and restoration of proprioceptive conduction. Posterior surgery …
View article: Epidemiological Characteristics of Acute‐on‐Chronic Liver Failure in Patients With Compensated Liver Disease: A Systematic Review and Meta‐Analysis
Epidemiological Characteristics of Acute‐on‐Chronic Liver Failure in Patients With Compensated Liver Disease: A Systematic Review and Meta‐Analysis Open
Aims Acute‐on‐chronic liver failure (ACLF) frequently develops in patients with compensated liver disease. We aimed to characterize the epidemiological features and mortality rates of ACLF in this population and their changes over time. Me…
View article: SHED-derived exosome-mimetics promotes rotator cuff tendon-bone healing via macrophage immunomodulation through NF-κB suppression and autophagy activation
SHED-derived exosome-mimetics promotes rotator cuff tendon-bone healing via macrophage immunomodulation through NF-κB suppression and autophagy activation Open
Rotator cuff tendon-bone healing is impeded by inflammation and inadequate regeneration. This study evaluates exosome-mimetics (EMs) derived from stem cells of human exfoliated deciduous teeth (SHEDs) as a therapeutic strategy to enhance r…
View article: Stationary Cycling Exercise With Virtual Reality to Reduce Depressive Symptoms Among People With Mild to Moderate Depression: Randomized Controlled Trial
Stationary Cycling Exercise With Virtual Reality to Reduce Depressive Symptoms Among People With Mild to Moderate Depression: Randomized Controlled Trial Open
Background Virtual reality (VR) stationary cycling provides a potential solution to enhance adherence and reduce depressive symptoms, particularly for people with depression. However, high-quality evidence is needed to support its implemen…
View article: Clinical, Microbiological, and Antibiotic Treatment Characteristics of Bacterial Infections in Patients with Liver Cirrhosis in China: A Multicenter Study
Clinical, Microbiological, and Antibiotic Treatment Characteristics of Bacterial Infections in Patients with Liver Cirrhosis in China: A Multicenter Study Open
The clinical and microbiological characteristics of bacterial infections in patients with cirrhosis in China differ substantially from those reported in other regions. These findings highlight the need for region-specific management and pr…
View article: Cobalt Chloride-simulated Hypoxia Promoted Ossification of the Posterior Longitudinal Ligament Through the HIF1A–BMP4 Axis
Cobalt Chloride-simulated Hypoxia Promoted Ossification of the Posterior Longitudinal Ligament Through the HIF1A–BMP4 Axis Open
Background: The ossification of the posterior longitudinal ligament (OPLL) is a progressive spinal disorder predominantly observed in Asian populations. Unfortunately, there is a limited availability of conservative therapies to impede the…
View article: A cross-sectional study of evaluating cervical spondylotic myelopathy based on gait and plantar pressures
A cross-sectional study of evaluating cervical spondylotic myelopathy based on gait and plantar pressures Open
View article: The epidemiological study of family-based Helicobacter pylori screening and its benefits: a cross-sectional study
The epidemiological study of family-based Helicobacter pylori screening and its benefits: a cross-sectional study Open
This study aimed to manage Helicobacter pylori (H. pylori) infection through a family-centered approach. It conducted a two-year follow-up on infected individuals' family members in Yichun, Jiangxi, China, to gain comprehensive insights in…
View article: Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery
Cord-lamina angle and foraminal diameter as key predictors of C5 palsy after anterior cervical decompression and fusion surgery Open
Background C5 nerve root palsy (C5P) is a rare but documented complication after cervical decompression surgery. Despite multiple proposed mechanisms, research on risk factors for C5P after anterior cervical discectomy and fusion (ACDF) re…
View article: TDF and its analogs have not survival advantage over entecavir for patients with Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure
TDF and its analogs have not survival advantage over entecavir for patients with Hepatitis B Virus-Associated Acute-on-Chronic Liver Failure Open
Background: Both entecavir and tenofovir are frequently prescribed for HBV-ACLF, however, their comparative efficacy were not fully clarified. The study aimed to compare the survival, virological and liver function response between patient…
View article: Risk factors and prognostic impact of new decompensated events in hospitalized patients with decompensated cirrhosis
Risk factors and prognostic impact of new decompensated events in hospitalized patients with decompensated cirrhosis Open
Patients with high MELD scores are susceptible to new decompensation during hospitalization, and the occurrence of new decompensation adversely affects short-term mortality in patients with DC.
View article: Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure
Evidence-based incorporation of key parameters into MELD score for acute-on-chronic liver failure Open
Background The model for end-stage liver disease (MELD) score is widely used for the prognostication in end-stage liver disease but has limited performance in acute-on-chronic liver failure (ACLF). In this study, we identified additional p…
View article: Hepatic and extrahepatic metabolic modulation in hbv-related decompensated cirrhosis and acute-on-chronic liver failure
Hepatic and extrahepatic metabolic modulation in hbv-related decompensated cirrhosis and acute-on-chronic liver failure Open
Acute-on-chronic liver failure (ACLF) and decompensated cirrhosis (DC) are life-threatening syndromes that can develop at the end-stage of chronic hepatitis B virus (HBV) infection. Both ACLF and DC are complicated by hepatic and extrahepa…
View article: A dynamic model to predict early occurrence of acute kidney injury in ICU hospitalized cirrhotic patients: a MIMIC database analysis
A dynamic model to predict early occurrence of acute kidney injury in ICU hospitalized cirrhotic patients: a MIMIC database analysis Open
View article: Assessing ChatGPT as a Medical Consultation Assistant for Chronic Hepatitis B: Cross-Language Study of English and Chinese
Assessing ChatGPT as a Medical Consultation Assistant for Chronic Hepatitis B: Cross-Language Study of English and Chinese Open
Background Chronic hepatitis B (CHB) imposes substantial economic and social burdens globally. The management of CHB involves intricate monitoring and adherence challenges, particularly in regions like China, where a high prevalence of CHB…
View article: The burden and predictors of 30-day unplanned readmission in patients with acute liver failure: a national representative database study
The burden and predictors of 30-day unplanned readmission in patients with acute liver failure: a national representative database study Open
View article: Development and Validation of a dynamic online nomogram predicting acute kidney injury in critically ill patients with cirrhosis
Development and Validation of a dynamic online nomogram predicting acute kidney injury in critically ill patients with cirrhosis Open
Background: This study aimed to develop a tool for predicting the occurrence of acute kidney injury (AKI) in critically ill patients with cirrhosis. Methods: Eligible patients with cirrhosis were identified from the Medical Information Mar…
View article: A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess
A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess Open
Aims: PLA (pyogenic liver abscess) has become a common disease, but the percentage of positive cultures of PLA is low. This study summarizes methods for empirically guiding the administration of PLA even without culture results. Method: Th…
View article: The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution
The clinical courses of HBV-related acute-on-chronic liver failure and a multi-state model to predict disease evolution Open
Background and Aims: Acute-on-chronic liver failure (ACLF) is a highly dynamic syndrome. The objective of this study was to delineate the clinical course of patients with HBV-ACLF and to develop a model to estimate the temporal evolution o…
View article: Citrullinemia type II accompanied by mental derangement combined with multidrug resistance 3 decrease, case report
Citrullinemia type II accompanied by mental derangement combined with multidrug resistance 3 decrease, case report Open
View article: Omicron COVID-19 variant outcomes and vaccination in non-severe and non-critical patients at admission
Omicron COVID-19 variant outcomes and vaccination in non-severe and non-critical patients at admission Open
The clinical data of patients infected with the Omicron variant virus in Zhejiang Province from January to 14 May 2022 were collected retrospectively. We analyzed the differences in symptoms, clinical categories of COVID-19, length of hosp…
View article: The burden of liver cirrhosis and underlying etiologies: results from the Global Burden of Disease Study 2019
The burden of liver cirrhosis and underlying etiologies: results from the Global Burden of Disease Study 2019 Open
Background: Liver cirrhosis is a major health concern. Herein, we aimed to estimate the incidence, prevalence, and mortality of liver cirrhosis caused by specific etiologies for 204 countries and territories. Materials and Methods: The dat…
View article: Prognosis prediction performs better in patients with non-cirrhosis hepatitis B virus-related acute-on-chronic liver failure than those with cirrhosis
Prognosis prediction performs better in patients with non-cirrhosis hepatitis B virus-related acute-on-chronic liver failure than those with cirrhosis Open
Background The accurate prediction of the outcome of hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is impeded by population heterogeneity. The study aimed to assess the impact of underlying cirrhosis on the performanc…
View article: Hepatitis E virus superinfection impairs long-term outcome in hospitalized patients with hepatitis B virus-related decompensated liver cirrhosis
Hepatitis E virus superinfection impairs long-term outcome in hospitalized patients with hepatitis B virus-related decompensated liver cirrhosis Open
View article: Vaccination with SARS-CoV-2 inactivated vaccines reduced the risk of anxiety and depression in a population majored by health care workers during the recent omicron variant outbreak
Vaccination with SARS-CoV-2 inactivated vaccines reduced the risk of anxiety and depression in a population majored by health care workers during the recent omicron variant outbreak Open
Background The mental health status of the population majored by health care workers in China during the omicron variant outbreak remains unknown. Furthermore, the effect of COVID-19 - inactivated vaccines on mental health is yet to be inv…
View article: One hundred and ninety-two weeks treatment of entecavir maleate for Chinese chronic hepatitis B predominantly genotyped B or C
One hundred and ninety-two weeks treatment of entecavir maleate for Chinese chronic hepatitis B predominantly genotyped B or C Open
Long-term ETV maleate treatment for up to 192 wk is effective and safe in Chinese CHB patients predominantly genotyped as B or C.
View article: Acute decompensation events differentially impact the risk of nosocomial infections and short-term outcomes in patients with cirrhosis
Acute decompensation events differentially impact the risk of nosocomial infections and short-term outcomes in patients with cirrhosis Open
Aims This research aimed to evaluate the influence of acute decompensation (AD) events upon admission on the subsequent risk of nosocomial infections (NIs) and the synergy between AD and the following NIs on the short-term outcome. Methods…
View article: Expert Consensus on Diagnosis and Treatment of End-Stage Liver Disease Complicated with Infections
Expert Consensus on Diagnosis and Treatment of End-Stage Liver Disease Complicated with Infections Open
End-stage liver disease (ESLD) is a life-threatening clinical syndrome that markedly increases mortality in patients with infections. In patients with ESLD, infections can induce or aggravate the occurrence of liver decompensation. Consequ…
View article: 240‐week entecavir maleate treatment in Chinese chronic hepatitis B predominantly genotype B or C
240‐week entecavir maleate treatment in Chinese chronic hepatitis B predominantly genotype B or C Open
This study aimed to evaluate the efficacy and safety of entecavir(ETV) versus ETV maleate in Chinese patients with chronic hepatitis B(CHB). This was a randomized, double‐blind, double‐dummy, controlled, multicentre study. Patients were ra…