Jifang Yu
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View article: Combined use of vitamin C and antifolates induces cuproptosis-like bacterial death
Combined use of vitamin C and antifolates induces cuproptosis-like bacterial death Open
Combined use of antimicrobial agents is a key strategy to combat antimicrobial resistance. After several decades of approval, clinical application of the classical combination co-trimoxazole has gradually become limited, mainly due to the …
View article: Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin
Diverse impacts of different rpoB mutations on the anti-tuberculosis efficacy of capreomycin Open
Funding for this study was provided by the National Key Research and Development Program of China (Grant no. 2021YFA1300901).
View article: The T120P or M172V mutation on <i>rv2172c</i> confers high level <i>para</i> -aminosalicylic acid resistance in <i>Mycobacterium tuberculosis</i>
The T120P or M172V mutation on <i>rv2172c</i> confers high level <i>para</i> -aminosalicylic acid resistance in <i>Mycobacterium tuberculosis</i> Open
Although para-aminosalicylic acid (PAS) has been used to treat tuberculosis for decades, mechanisms of resistance to this drug in Mycobacterium tuberculosis (M. tuberculosis) clinical isolates have not been thoroughly investigated. Previou…
View article: Association between mutations in a <i>thyX-hsdS.1</i> region and <i>para</i>-aminosalicylic acid resistance in <i>Mycobacterium tuberculosis</i> clinical isolates
Association between mutations in a <i>thyX-hsdS.1</i> region and <i>para</i>-aminosalicylic acid resistance in <i>Mycobacterium tuberculosis</i> clinical isolates Open
Although para-aminosalicylic acid (PAS) has been used to treat tuberculosis agent for decades, its mechanisms of resistance are still not thoroughly understood. Previously, sporadic studies showed that certain mutations in the thyX-hsdS.1 …
View article: Competition between H4PteGlu and H2PtePAS Confers para-Aminosalicylic Acid Resistance in Mycobacterium tuberculosis
Competition between H4PteGlu and H2PtePAS Confers para-Aminosalicylic Acid Resistance in Mycobacterium tuberculosis Open
Tuberculosis remains a serious challenge to human health worldwide. para-Aminosalicylic acid (PAS) is an important anti-tuberculosis drug, which requires sequential activation by Mycobacterium tuberculosis (M. tuberculosis) dihydropteroate…
View article: Association between mutations in a <i>thyX-hsdS.1</i> region and <i>para</i> -aminosalicylic acid resistance in <i>Mycobacterium tuberculosis</i> clinical isolates
Association between mutations in a <i>thyX-hsdS.1</i> region and <i>para</i> -aminosalicylic acid resistance in <i>Mycobacterium tuberculosis</i> clinical isolates Open
Although para-aminosalicylic acid (PAS) has been used to treat tuberculosis agent for decades, its mechanisms of resistance are still not thoroughly understood. Previously, sporadic studies showed that certain mutations in the thyX-hsdS.1 …
View article: MgrB Inactivation Confers Trimethoprim Resistance in Escherichia coli
MgrB Inactivation Confers Trimethoprim Resistance in Escherichia coli Open
After several decades of use, trimethoprim (TMP) remains one of the key access antimicrobial drugs listed by the World Health Organization. To circumvent the problem of trimethoprim resistance worldwide, a better understanding of drug-resi…