Jifei Chen
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View article: AI-enhanced diagnostic model for pulmonary nodule classification
AI-enhanced diagnostic model for pulmonary nodule classification Open
Background The identification of benign and malignant pulmonary nodules (BPN and MPN) can significantly reduce mortality. However, a reliable and validated diagnostic model for clinical decision-making is still lacking. Methods Enzyme-link…
View article: Design and Analysis of a 5-Degree of Freedom (DOF) Hybrid Three-Nozzle 3D Printer for Wood Fiber Gel Material
Design and Analysis of a 5-Degree of Freedom (DOF) Hybrid Three-Nozzle 3D Printer for Wood Fiber Gel Material Open
Wood is an organic renewable natural resource. Cellulose, hemicellulose and lignin in wood are used in tissue engineering, biomedicine and other fields because of their good properties. This paper reported that the possibility of wood fibe…
View article: Energy Saving Design and Optimization of suspension System in Baja Competition for College Students
Energy Saving Design and Optimization of suspension System in Baja Competition for College Students Open
The suspension design and optimization of Baja car were carried out on the premise of meeting the rules of the race in order to improve the handling stability and ride smoothness of the car. Firstly established the 3 d modelling software U…
View article: The Value of a Seven-Autoantibody Panel Combined with the Mayo Model in the Differential Diagnosis of Pulmonary Nodules
The Value of a Seven-Autoantibody Panel Combined with the Mayo Model in the Differential Diagnosis of Pulmonary Nodules Open
Background. Identifying malignant pulmonary nodules and detecting early-stage lung cancer (LC) could reduce mortality. This study investigated the clinical value of a seven-autoantibody (7-AAB) panel in combination with the Mayo model for …
View article: Design and optimization of main reducer based on Baja racing
Design and optimization of main reducer based on Baja racing Open
The main reducer is the main component of the whole vehicle, and its main function is to realize deceleration and torque increase. For Baha racing car, in order to improve the dynamic performance of the whole car, the main reducer is desig…
View article: The Severity of CVB3‐Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice
The Severity of CVB3‐Induced Myocarditis Can Be Improved by Blocking the Orchestration of NLRP3 and Th17 in Balb/c Mice Open
Background . The functional characteristics of NLRP3 in the pathogenesis of coxsackievirus B3‐ (CVB3‐) induced viral myocarditis (VMC) have not been fully elucidated, and the targeted therapeutic effect of NLRP3 or its related pathway in V…
View article: Lack of Efficacy of Combined Carbohydrate Antigen Markers for Lung Cancer Diagnosis
Lack of Efficacy of Combined Carbohydrate Antigen Markers for Lung Cancer Diagnosis Open
Background. Lung cancer (LC) is top-ranked in cancer incidence and is the leading cause of cancer death globally. Combining serum biomarkers can improve the accuracy of LC diagnosis. The identification of the best potential combination of …
View article: High-Dose Vitamin C Tends to Kill Colorectal Cancer with High MALAT1 Expression
High-Dose Vitamin C Tends to Kill Colorectal Cancer with High MALAT1 Expression Open
Background. Vitamin C (Vc) deficiency is frequently observed in cancer sites and has been proposed to have an antitumor effect. However, the mechanism of Vc’s killing effect is not clear. Besides, epigenetic alterations exhibit significant…
View article: The Value of A Seven-Autoantibody Panel Combined With The Mayo Model In The Differential Diagnosis of Pulmonary Nodules 
The Value of A Seven-Autoantibody Panel Combined With The Mayo Model In The Differential Diagnosis of Pulmonary Nodules Open
BACKGROUND : Identifying malignant pulmonary nodules and detecting early-stage lung cancer (LC) could reduce mortality. This study investigated the clinical value of a seven-autoantibody (7-AAB) panel in combination with the Mayo model for…
View article: Anti-TGF-β attenuates tumor growth via polarization of tumor associated neutrophils towards an anti-tumor phenotype in colorectal cancer
Anti-TGF-β attenuates tumor growth via polarization of tumor associated neutrophils towards an anti-tumor phenotype in colorectal cancer Open
Tumor associated neutrophils (TANs) play important roles in the progress of CRC. Since tumor microenvironments could influence the phenotypes of TANs, altering the tumor microenvironment to polarize the phenotype of TANs may be a new strat…
View article: LncRNA TGFB2-AS1 regulates lung adenocarcinoma progression via act as a sponge for miR-340-5p to target EDNRB expression.
LncRNA TGFB2-AS1 regulates lung adenocarcinoma progression via act as a sponge for miR-340-5p to target EDNRB expression. Open
Long non-coding RNA TGFB2-antisense RNA1 (TGFB2-AS1) has been reported could regulate tumorigenesis. However, the roles of TGFB2-AS1 in lung adenocarcinoma (LUAD) remain largely unknown. In this work, we aimed to explore the expression lev…
View article: sTLR4/sMD‑2 complex alleviates LPS‑induced acute lung injury by inhibiting pro‑inflammatory cytokines and chemokine CXCL1 expression
sTLR4/sMD‑2 complex alleviates LPS‑induced acute lung injury by inhibiting pro‑inflammatory cytokines and chemokine CXCL1 expression Open
Activation of Toll-like receptor 4 (TLR4) and its accessory proteins myeloid differentiation protein 2 (MD-2) can trigger immune and inflammatory activities, and contribute to developing chronic inflammatory diseases. The formation of the …
View article: Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis
Intra-articular injection of kartogenin-conjugated polyurethane nanoparticles attenuates the progression of osteoarthritis Open
Osteoarthritis (OA) is the most common form of joint disease and a leading cause of physical disability, there is an urgent need to attenuate the progression of OA. Intra-articular (IA) injection is an effective treatment for joints diseas…
View article: Identifying Patients Who Will Most Benefit from Single Photon Emission Computerized Tomography and Computerized Tomography After Femoral Neck Fracture
Identifying Patients Who Will Most Benefit from Single Photon Emission Computerized Tomography and Computerized Tomography After Femoral Neck Fracture Open
BACKGROUND Single photon emission computerized tomography and computerized tomography (SPECT/CT) is useful for assessing blood supply within the femoral head after femoral neck fracture, but its use in all femoral neck fracture patients is…
View article: sTLR4/MD-2 complex inhibits colorectal cancer migration and invasiveness and by lncRNA H19 down-regulation
sTLR4/MD-2 complex inhibits colorectal cancer migration and invasiveness and by lncRNA H19 down-regulation Open
Long non-coding RNAs (lncRNAs) have multiple functions in gene regulation and during cellular processes. However, the functional roles of lncRNAs in colorectal cancer (CRC) have not yet been well understood. In our previous study, we demon…
View article: Parathyroid Hormone (PTH) Induces Autophagy to Protect Osteocyte Cell Survival from Dexamethasone Damage
Parathyroid Hormone (PTH) Induces Autophagy to Protect Osteocyte Cell Survival from Dexamethasone Damage Open
BACKGROUND Glucocorticoids (GC) have direct adverse effects on osteocytes, the most abundant bone cell type, and play an important role in osteonecrosis of the femoral head (ONFH). Teriparatide has been reported to be an effective treatmen…
View article: Regulatory effect of microRNA‐34a on osteogenesis and angiogenesis in glucocorticoid‐induced osteonecrosis of the femoral head
Regulatory effect of microRNA‐34a on osteogenesis and angiogenesis in glucocorticoid‐induced osteonecrosis of the femoral head Open
Glucocorticoid‐induced osteonecrosis of the femoral head (GIOFH) is a common and devastating orthopedic disease, and its underlying mechanism remains unclear. The aim of this study was to determine the role of microRNA‐34a (mir‐34a) in GIO…
View article: Free Vascularized Fibular Grafting Improves Vascularity Compared With Core Decompression in Femoral Head Osteonecrosis: A Randomized Clinical Trial
Free Vascularized Fibular Grafting Improves Vascularity Compared With Core Decompression in Femoral Head Osteonecrosis: A Randomized Clinical Trial Open
Level I, therapeutic study.
View article: Stromal cell-derived factor-1α and transforming growth factor-β<sub>1</sub> synergistically facilitate migration and chondrogenesis of synovium-derived stem cells through MAPK pathways.
Stromal cell-derived factor-1α and transforming growth factor-β<sub>1</sub> synergistically facilitate migration and chondrogenesis of synovium-derived stem cells through MAPK pathways. Open
The clinical translation of tissue engineering methods is confined by the limited external cell sources, which is hopefully to be addressed by the cell guidance approach as cytokine-induced homing and differentiation of the patients' autol…
View article: Aspirin inhibits the proliferation of synovium-derived mesenchymal stem cells by arresting the cell cycle in the G0/G1 phase.
Aspirin inhibits the proliferation of synovium-derived mesenchymal stem cells by arresting the cell cycle in the G0/G1 phase. Open
Mesenchymal stem cells (MSCs) provide promising applications for clinical treatments. However, patients often take medications that affect the viability of transplanted MSCs. The aim of this study was to assess the effects and underlying m…
View article: Efficacy and safety of Wuling San for treatment of breast-cancer-related upper extremity lymphoedema: study protocol for a pilot trial
Efficacy and safety of Wuling San for treatment of breast-cancer-related upper extremity lymphoedema: study protocol for a pilot trial Open
Introduction Breast-cancer-related upper extremity lymphoedema (BCUL), a common complication of mastectomy, can cause physical discomfort, psychological distress, cosmetic defects, functional disability and chronic recurrent erysipelas in …
View article: Natural ageing process accelerates the release of Ag from functional textile in various exposure scenarios
Natural ageing process accelerates the release of Ag from functional textile in various exposure scenarios Open
Natural ageing process occurs throughout the life cycle of textile products, which may possess influences on the release behavior of additives such as silver nanoparticles (Ag NPs). In this study, we assessed the releasability of Ag NPs fr…
View article: sTLR4/MD-2 complex inhibits colorectal cancer in vitro and in vivo by targeting LPS
sTLR4/MD-2 complex inhibits colorectal cancer in vitro and in vivo by targeting LPS Open
Colorectal cancer (CRC) is aggressive and associated with TLR4-MD-2 signaling. Toll-like receptor 4 (TLR4) and myeloid differentiation protein 2 (MD-2) were highly expressed in human CRC. The soluble form of extracellular TLR4 domain (sTLR…