Jingcao Huang
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View article: Chidamide and cytarabine synergistically treat acute myeloid leukemia: inhibiting ribosome biogenesis via the MYC-RRP9 pathway
Chidamide and cytarabine synergistically treat acute myeloid leukemia: inhibiting ribosome biogenesis via the MYC-RRP9 pathway Open
View article: Visual Detection on Aircraft Wing Icing Process Using a Lightweight Deep Learning Model
Visual Detection on Aircraft Wing Icing Process Using a Lightweight Deep Learning Model Open
Aircraft wing icing significantly threatens aviation safety, causing substantial losses to the aviation industry each year. High transparency and blurred edges of icing areas in wing images pose challenges to wing icing detection by machin…
View article: A comprehensive analysis of bone marrow-derived cytogenetic abnormalities in multiple myeloma patients with extramedullary disease
A comprehensive analysis of bone marrow-derived cytogenetic abnormalities in multiple myeloma patients with extramedullary disease Open
Our findings underscore the importance of integrating cytogenetic data into risk stratification for MM patients with EMD. These results also highlight the need for further research to elucidate the mechanisms underlying cytogenetic abnorma…
View article: A Comprehensive Analysis of Bone Marrow-Derived Cytogenetic Abnormalities in Multiple Myeloma Patients with Extramedullary Disease
A Comprehensive Analysis of Bone Marrow-Derived Cytogenetic Abnormalities in Multiple Myeloma Patients with Extramedullary Disease Open
Extramedullary disease (EMD) in multiple myeloma (MM) remains a critical clinical challenge due to its aggressive behavior and resistance to conventional therapies. While cytogenetic abnormalities are recognized contributors to MM progress…
View article: Dihydrolipoamide dehydrogenase (DLD) is a novel molecular target of bortezomib
Dihydrolipoamide dehydrogenase (DLD) is a novel molecular target of bortezomib Open
View article: The Hoechst Side Population Cells can be Effectively Detected by 375nm and 405nm Lasers
The Hoechst Side Population Cells can be Effectively Detected by 375nm and 405nm Lasers Open
The side population (SP) cells are identified through Hoechst 33342 staining and analyzed using flow cytometry (FCM). The Hoechst SP method is utilized for the isolation of stem cells based on the dye efflux properties of ATP-binding casse…
View article: Ferroptosis-related prognostic model of mantle cell lymphoma
Ferroptosis-related prognostic model of mantle cell lymphoma Open
Background Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin’s lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis related genes for …
View article: Inspirations from installation art: creating open stories and using found works in a post-apocalypse animation
Inspirations from installation art: creating open stories and using found works in a post-apocalypse animation Open
This research is a practice-based research and also an art-based research. The major project of this study is the open screenplay of The Hero's Journey, and its animated section (section 1) that uses found works and multiple production tec…
View article: A Ferroptosis-Related Prognostic Model of Mantle Cell Lymphoma
A Ferroptosis-Related Prognostic Model of Mantle Cell Lymphoma Open
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin's lymphoma. Ferroptosis, an iron-dependent programmed cell death, is closely related to cancer prognosis. In this study, we established a model of ferroptosis-related genes for prognostic …
View article: Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma
Combinations of ivermectin with proteasome inhibitors induce synergistic lethality in multiple myeloma Open
Multiple myeloma (MM) is an incurable malignancy of plasma cells. Ivermectin is a US Food and Drug Administration-approved drug for antiparasitic use. Here, we showed that ivermectin exerted anti-MM effects and significantly synergized wit…
View article: Correlation of Aggrephagy Signaling and Multiple Myeloma Immune Microenvironment Composition
Correlation of Aggrephagy Signaling and Multiple Myeloma Immune Microenvironment Composition Open
View article: Liposome-Encapsulated Melphalan Exhibits Potent Antimyeloma Activity and Reduced Toxicity
Liposome-Encapsulated Melphalan Exhibits Potent Antimyeloma Activity and Reduced Toxicity Open
Multiple myeloma (MM), a plasma cell cancer in bone marrow, remains an incurable disease. Melphalan, an alkylating agent, is a conventional anticancer drug that is still widely used for MM treatment in clinics. However, melphalan-induced o…
View article: ISG20L2 suppresses bortezomib antimyeloma activity by attenuating bortezomib binding to PSMB5
ISG20L2 suppresses bortezomib antimyeloma activity by attenuating bortezomib binding to PSMB5 Open
The proteasome inhibitors (PIs) bortezomib and carfilzomib, which target proteasome 20S subunit beta 5 (PSMB5) in cells, are widely used in multiple myeloma (MM) treatment. In this study, we demonstrated the role of interferon-stimulated 2…
View article: ALCAM regulates multiple myeloma chemoresistant side population
ALCAM regulates multiple myeloma chemoresistant side population Open
Drug-resistance is a major problem preventing a cure in patients with multiple myeloma (MM). Previously, we demonstrated that activated-leukocyte-cell-adhesion-molecule (ALCAM) is a prognostic factor in MM and inhibits EGF/EGFR-initiated M…
View article: Liposome Encapsulated Melphalan Exhibits Potent Anti-Myeloma Activity and Reduced Toxicity
Liposome Encapsulated Melphalan Exhibits Potent Anti-Myeloma Activity and Reduced Toxicity Open
View article: Dasatinib and interferon alpha synergistically induce pyroptosis-like cell death in philadelphia chromosome positive acute lymphoblastic leukemia.
Dasatinib and interferon alpha synergistically induce pyroptosis-like cell death in philadelphia chromosome positive acute lymphoblastic leukemia. Open
Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) is a high-risk disease subtype with a dismal prognosis. Inhibiting BCR-ABL kinase alone is insufficient to eradicate Ph+ALL clones, and alternative BCR-ABL-dependent an…
View article: A novel immune prognostic model of non-M3 acute myeloid leukemia.
A novel immune prognostic model of non-M3 acute myeloid leukemia. Open
Acute myeloid leukemia (AML) is a common hematological malignancy in adults. AML patients exhibit clinical heterogeneity with complications of molecular basis. The leukemogenesis of AML involves immune escape, and the immunosuppression sta…
View article: Minimal residual disease in multiple myeloma: current status
Minimal residual disease in multiple myeloma: current status Open
View article: ALCAM-EGFR interaction regulates myelomagenesis
ALCAM-EGFR interaction regulates myelomagenesis Open
Multiple myeloma, a plasma cell malignancy in the bone marrow, remains largely incurable with currently available therapeutics. In this study, we discovered that the activated leukocyte cell adhesion molecule (ALCAM) interacted with epider…
View article: Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma
Intratumor Heterogeneity of MIF Expression Correlates With Extramedullary Involvement of Multiple Myeloma Open
Macrophage migration inhibitory factor (MIF) has been shown to promote disease progression in many malignancies, including multiple myeloma (MM). We previously reported that MIF regulates MM bone marrow homing and knockdown of MIF favors t…
View article: BMI1 regulates multiple myeloma-associated macrophage’s pro-myeloma functions
BMI1 regulates multiple myeloma-associated macrophage’s pro-myeloma functions Open
Multiple myeloma (MM) is an aggressive malignancy characterized by terminally differentiated plasma cells accumulation in the bone marrow (BM). MM BM exhibits elevated MΦs (macrophages) numbers relative to healthy BM. Current evidence indi…
View article: High Wilms’ tumor 1 associating protein expression predicts poor prognosis in acute myeloid leukemia and regulates m6A methylation of MYC mRNA
High Wilms’ tumor 1 associating protein expression predicts poor prognosis in acute myeloid leukemia and regulates m6A methylation of MYC mRNA Open
View article: <p>PIM3 Promotes the Proliferation and Migration of Acute Myeloid Leukemia Cells</p>
PIM3 Promotes the Proliferation and Migration of Acute Myeloid Leukemia Cells Open
Our findings suggest that PIM3 regulates the proliferation, survival, and chemotaxis of AML cell lines. Moreover, pCXCR4 might mediate the regulation of PIM3-induced chemotaxis. Therefore, the inhibition of PIM3 expression may be a …
View article: Chidamide plus decitabine synergistically induces apoptosis of acute myeloid leukemia cells by upregulating <i>PERP</i>.
Chidamide plus decitabine synergistically induces apoptosis of acute myeloid leukemia cells by upregulating <i>PERP</i>. Open
Acute myeloid leukemia (AML) is a malignant clonal disease that originates from hematopoietic stem cells. Because AML has a generally unsatisfactory long-term prognosis, new therapeutic options are required. To this end, we explored the ef…
View article: Wharton’s jelly mesenchymal stem cell-based or umbilical vein endothelial cell-based serum-free coculture with cytokines supports the ex vivo expansion/maintenance of cord blood hematopoietic stem/progenitor cells
Wharton’s jelly mesenchymal stem cell-based or umbilical vein endothelial cell-based serum-free coculture with cytokines supports the ex vivo expansion/maintenance of cord blood hematopoietic stem/progenitor cells Open
View article: Progressive Diffuse Large B-cell Lymphoma with <i>TP53</i> Gene Mutation Treated with Chidamide-Based Chemotherapy
Progressive Diffuse Large B-cell Lymphoma with <i>TP53</i> Gene Mutation Treated with Chidamide-Based Chemotherapy Open
We attempted to explore novel treatment options for progressive diffuse large B-cell lymphoma (DLBCL) with TP53 mutation that has a poor response to rituximab-based immunochemotherapy. Herein, we report the case of a patient with DLBCL hav…
View article: <i><scp>SLC</scp>2A5</i> overexpression in childhood philadelphia chromosome‐positive acute lymphoblastic leukaemia
<i><span>SLC</span>2A5</i> overexpression in childhood philadelphia chromosome‐positive acute lymphoblastic leukaemia Open
Summary To study glycolysis/glycogenesis‐related genes expression in childhood B‐cell acute lymphoblastic leukaemia (B‐ ALL ), we performed a microarray‐based analysis using published gene expression profiles. We found that SLC 2A5 , which…
View article: Antiproliferative and Apoptosis Triggering Potential of Paclitaxel-Based Targeted-Lipid Nanoparticles with Enhanced Cellular Internalization by Transferrin Receptors—a Study in Leukemia Cells
Antiproliferative and Apoptosis Triggering Potential of Paclitaxel-Based Targeted-Lipid Nanoparticles with Enhanced Cellular Internalization by Transferrin Receptors—a Study in Leukemia Cells Open
View article: Targeting of HER3 with Functional Cooperative miRNAs Enhances Therapeutic Activity in HER2-Overexpressing Breast Cancer Cells
Targeting of HER3 with Functional Cooperative miRNAs Enhances Therapeutic Activity in HER2-Overexpressing Breast Cancer Cells Open
View article: Hypoxia with Wharton’s jelly mesenchymal stem cell coculture maintains stemness of umbilical cord blood-derived CD34+ cells
Hypoxia with Wharton’s jelly mesenchymal stem cell coculture maintains stemness of umbilical cord blood-derived CD34+ cells Open