Jigme Dorji
YOU?
Author Swipe
View article: In vivo inhibition of c-MYC in the metastatic drug-resistant ovarian cancer cells down regulates the c-MYC-PD-L1-PAX8-p21 to achieve therapeutic efficacy
In vivo inhibition of c-MYC in the metastatic drug-resistant ovarian cancer cells down regulates the c-MYC-PD-L1-PAX8-p21 to achieve therapeutic efficacy Open
Metastatic, drug-resistant ovarian cancer is the deadliest form of gynecological cancer afflicting women globally, with > 49% relapse rate following initial diagnosis, surgery and treatment. High-grade serous ovarian cancer is the most dia…
View article: c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes
c-MYC mRNA destabilization inhibited lethal pancreatic cancer in vivo with significant survival outcomes Open
Pancreatic ductal carcinoma is the most common and deadly form of pancreatic cancer, with an 11% survival rate. There is currently no cure. The first-line, mainstay therapy for pancreatic cancer is gemcitabine, capecitabine, or FOLFIRINOX.…
View article: Participatory Forest Management and Gender Inclusiveness within the Community Forest Management Groups of Bhutan
Participatory Forest Management and Gender Inclusiveness within the Community Forest Management Groups of Bhutan Open
Community forest management groups (CFMGs) in Bhutan exhibit participatory forest management practices that recognize the importance of community's collective participation in the management of natural forest resources. This approach invol…
View article: Vegetation Composition of Paphiopedilum Fairrieanum (Lindl.) Stein in Brongshing Locality, Samdrup Jongkhar District
Vegetation Composition of Paphiopedilum Fairrieanum (Lindl.) Stein in Brongshing Locality, Samdrup Jongkhar District Open
Paphiopedilum fairrieanum (Lindl.) Stein is a terrestrial orchid, which is found in India, Nepal, and Bhutan, and the International Union of Conservation of Nature (IUCN) listed it as a Critically Endangered (CR) species of orchid in 2015.…
View article: Cattle Maternal Diversity Inferred From 1,883 Taurine And Indicine Mitogenomes
Cattle Maternal Diversity Inferred From 1,883 Taurine And Indicine Mitogenomes Open
Maternal diversity based on a sub-region of mitochondrial genome or variants were commonly used to understand past demographic events in livestock. Additionally, there is growing evidence of direct association of mitochondrial genetic vari…
View article: Ecotourism Destination Assessment using Tourist Potential Index in Zhemgang Dzongkhag, Bhutan
Ecotourism Destination Assessment using Tourist Potential Index in Zhemgang Dzongkhag, Bhutan Open
Zhemgang is increasingly becoming a preferred destination for nature-based tourism with the increasing number of international visitors from 165 to 346 between 2013 and 2019. The attractions that contribute to the increasing number of visi…
View article: Water-Based Therapies of Bhutan: Current Practices and the Recorded Clinical Evidence of Balneotherapy
Water-Based Therapies of Bhutan: Current Practices and the Recorded Clinical Evidence of Balneotherapy Open
Medical water therapy (also called medical hydrology) is practiced worldwide both for relaxation and treatment of diseases. While this practice is still thriving in Bhutan, there is a lack of proper documentation and critical study. Theref…
View article: Analysis of adverse drug reactions reported to national pharmacovigilance center of Bhutan
Analysis of adverse drug reactions reported to national pharmacovigilance center of Bhutan Open
Introduction: Medicines prescribed for diseases often causes adverse drug reactions in patients ranging from mere inconvenience to permanent disability and death. This is because, most of the adverse drug reactions especially the serious a…
View article: Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Background Mutations in the mitochondrial genome have been implicated in mitochondrial disease, often characterized by impaired cellular energy metabolism. Cellular energy metabolism in mitochondria involves mitochondrial proteins (MP) fro…
View article: Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Background: Mutations in the mitochondrial genome have been implicated in mitochondrial disease, often characterised by impaired cellular energy metabolism. Cellular energy metabolism in mitochondria involves mitochondrial proteins (MP) fr…
View article: Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Background Mutations in the mitochondrial genome have been implicated in mitochondrial disease, often characterised by impaired cellular energy metabolism. Cellular energy metabolism in mitochondria involves mitochondrial proteins (MPs) fr…
View article: Additional file 3 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 3 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 3: Table S3. Read alignment quality check.
View article: Additional file 10 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 10 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 10: Table S8. KEGG pathway enrichment of the non-mitochondrial protein (Non-MP) genes in NuMP-MtMP cluster in the Main Cows
View article: Additional file 1 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 1 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 1: Table S1. Average RIN by tissue types.
View article: Additional file 2 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 2 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 2: Table S2. Quality of library preparation.
View article: Additional file 17 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 17 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 17: Table S9. Number of differentially expressed gene (DEG) s and their direction in tissues by gene categories in the Validation Cow.
View article: Additional file 4 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 4 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 4: Table S4. List of Mitochondrial protein genes derived from Mitocarta in cattle.
View article: Additional file 5 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 5 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 5: Table S5. List of Mitochondrial protein genes derived from Mitocarta in Sheep.
View article: Additional file 18 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 18 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 18: Table S10. Number of differentially expressed gene (DEG) s and their direction in tissues by gene categories in the Validation Sheep.
View article: Additional file 9 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 9 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 9: Table S7. List of non-mitochondrial protein (Non-MP) genes clustering with the mitochondrial protein genes in cluster I (NuMP-MtMP cluster) in the Main Cows.
View article: Additional file 6 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle
Additional file 6 of Expression of mitochondrial protein genes encoded by nuclear and mitochondrial genomes correlate with energy metabolism in dairy cattle Open
Additional file 6: Table S6. Number of differentially expressed (DE) genes by gene categories averaged for two foetuses in the Main Cows.
View article: Knowledge, attitude and practice on advanced cardiac life support (ACLS) among the general duty medical officers in Bhutan
Knowledge, attitude and practice on advanced cardiac life support (ACLS) among the general duty medical officers in Bhutan Open
Advanced cardiac life support (ACLS) is one of the important lifesaving procedures administered by emergency medical professionals. International guidelines and literature recommends periodic training of health personnel on ACLS. In Bhutan…
View article: Genetic diversity and population structure of three traditional horse breeds of Bhutan based on 29 DNA microsatellite markers
Genetic diversity and population structure of three traditional horse breeds of Bhutan based on 29 DNA microsatellite markers Open
The genetic variability and population structure of three Bhutanese traditional horse breeds were assessed through genotyping of 74 horses (Boeta 25, Sharta 14 and Yuta 35) for 29 microsatellite DNA loci. Altogether, 282 alleles were detec…
View article: Regulation of Medicines in Bhutan: Current Status, Challenges and Opportunities
Regulation of Medicines in Bhutan: Current Status, Challenges and Opportunities Open
Medicines Regulatory Agencies (MRAs) are responsible for evaluation of quality, safety and efficacy of medicinal products before it is approved for consumption. The regulatory procedures, however, differs from one country to another. Medic…
View article: Decline of Jakar sheep population in pastoral communities of Bhutan: A consequence of diminishing utility, alternate income opportunities and increasing challenges
Decline of Jakar sheep population in pastoral communities of Bhutan: A consequence of diminishing utility, alternate income opportunities and increasing challenges Open
Jakar sheep population in Bhutan is declining at unprecedented rate (44.4% per annum), and current population is little over 1,700. This study attempts to understand the current status of Jakar sheep and investigate the causes and drivers …