Explanipedia

Impact of Abatacept Inclusive Graft-Versus-Host Disease Prophylaxis in Pediatric Stem Cell Transplantation for Hemoglobinopathy Open

Niketa C. Shah, Alexander Ngwube, Tara Suresh, Anna Sowa, Allistair Abraham , et al. · 2025

Allogeneic hematopoietic cell transplantation (HCT) provides a curative option for patients with hemoglobinopathies by establishing donor-derived hematopoiesis. However, outcomes are compromised by toxicities and graft-versus-host disease …

Links across disabilities: unveiling associations between functional domains Open

Jignesh Dalal, Sophie Mitra, Ananthu James, Minerva Rivas Velarde · 2024

Background Persons with disabilities experience higher risks of mortality as well as poorer health as compared to the general population. The aim of this study is to estimate the correlations between functional difficulties across several …

Prospective PTCTC trial of myeloablative haplo-BMT with posttransplant cyclophosphamide for pediatric acute leukemias Open

Juan C. Fierro Pineda, Hua‐Ling Tsai, Amanda L. Blackford, Andrew Cluster, Emi Caywood , et al. · 2023

Promising results have been reported for adult patients with high-risk hematologic malignancies undergoing haploidentical bone marrow transplant (haploBMT) with posttransplant cyclophosphamide (PTCy). To our knowledge, we report results fr…

Editorial: Advances in the treatment of chronic myeloid leukemia Open

Ahmet Emre Eşkazan, Chung Hoow Kok, David T Yeung, Jignesh Dalal, Mario Tiribelli · 2023

EDITORIAL article Front. Oncol., 09 March 2023Sec. Hematologic Malignancies Volume 13 - 2023 | https://doi.org/10.3389/fonc.2023.1166588

Traffic jam within lymphocytes: A clinician’s perspective Open

Smitha Hosahalli Vasanna, Jignesh Dalal · 2023

With the discovery of novel diseases and pathways, as well as a new outlook on certain existing diseases, cellular trafficking disorders attract a great deal of interest and focus. Understanding the function of genes and their products in …

Case report: Daratumumab treatment in pre-transplant alloimmunization and severe hemolytic anemia Open

María A. Pereda, Smitha Hosahalli Vasanna, Neha J. Desai, Victoria J. Deng, Amma Owusu‐Ansah , et al. · 2022

Daratumumab, a CD38 monoclonal antibody that has been FDA-approved to treat multiple myeloma, has acquired popularity and is used off-label for both auto- and alloantibody mediated disorders, particularly in refractory/resistant circumstan…

Foreword Open

Jignesh Dalal · 2022

Leukemia is a hematological malignancy caused by clonal proliferation of abnormal lymphoid or hematopoietic cells in the bone marrow and/or lymphoid system. There are many different types of leukemias. Acute leukemia progresses fast, and p…

Cutaneous vesicles in an infant after bone marrow transplantation Open

Maria A. Pereda, Kelly Scarberry, Jignesh Dalal · 2022

Eight-month-old infant who recently received a matched unrelated donor transplant for malignant infantile osteopetrosis was admitted on T+48 for the evaluation of fevers. Her complete blood count (CBC) on admission showed a neutrophil coun…

Correction to: Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients Open

Hasan Hashem, Giorgia Bucciol, Seza Özen, Şule Ünal, İkbal Ok Bozkaya , et al. · 2022

Secondary hemophagocytic lymphohistiocytosis associated with Rocky Mountain spotted fever in a toddler: A case report Open

Smitha Hosahalli Vasanna, Peter Paul Lim, Tanya Saeeda Khan, Jignesh Dalal · 2022

A three‐year‐old boy presented with fever, maculopapular rash involving palms and soles, and hyponatremia two weeks following a tick bite. Empiric doxycycline that he was on was discontinued following negative initial rickettsial serology …

Clinical Features, Cancer Biology, Transplant Approach and Other Integrated Management Strategies for Wiskott–Aldrich Syndrome Open

Smitha Hosahalli Vasanna, María A. Pereda, Jignesh Dalal · 2021

Wiskott-Aldrich syndrome (WAS) is a rare X-linked recessive inborn error of immunity (IEI) first described in 1937. Classic WAS is characterized by the triad of thrombocytopenia with small platelets, recurrent infections due to combined im…

Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients Open

Hasan Hashem, Giorgia Bucciol, Seza Özen, Şule Ünal, İkbal Ok Bozkaya , et al. · 2021

Thrombotic Microangiopathy: Multi-Institutional Review of Pediatric Patients Who Underwent HSCT Open

Archana Ramgopal, Shiva Sridar, Jignesh Dalal, Ramasubramanian Kalpatthi · 2021

Thrombotic microangiopathy (TMA) is a rare but serious complication of hematopoietic stem cell transplantation (HSCT). The purpose of our study is to estimate the incidence, prevalence, and analyze the risk factors and outcome of TMA in ch…

Wiskott Aldrich syndrome: healthcare utilizations and disparities in transplant care Open

Nikki Agarwal, Divyaswathi Citla Sridhar, Sindhoosha Malay, Nirav Patil, Anjali Shekar , et al. · 2021

Patient with Down syndrome and relapsed acute lymphoblastic leukemia with sustained remission despite only partial R3 chemotherapy Open

Zhongbo Hu, Kristen A. VanHeyst, Jignesh Dalal, Lisa Hackney · 2021

DS‐ALL has a higher rate of relapse and treatment‐related mortality. The newer immunotherapies are potentially better options. Relapsed ALL with positive MRD has a poor prognosis. Transient long‐term remission after ALL relapse due to part…

Thrombotic Microangiopathy: Multi-Institutional Review of Pediatric Patients Who Underwent HSCT Open

Archana Ramgopal, Shiva Sridhar, Jignesh Dalal, Ram Kalpatthi · 2021

Thrombotic microangiopathy (TMA) is a rare but serious complication of hematopoietic stem cell transplantation (HSCT). The purpose of our study is to estimate the incidence and risk factors of TMA in 93 out of a total of 12369 children (0.…

Correction to: Infections in Infants with SCID: Isolation, Infection Screening and Prophylaxis in PIDTC Centers Open

Morna J. Dorsey, Nicola Wright, Natalia S. Chaimowitz, Blachy J. Dávila Saldaña, Holly Miller , et al. · 2020

Pre-Transplant Marital Status and Hematopoietic Cell Transplantation Outcomes Open

Jason Tay, Sara Beattie, Christopher Bredeson, Ruta Brazauskas, Na He , et al. · 2020

Background: Evidence about the impact of marital status before hematopoietic cell transplantation (hct) on outcomes after hct is conflicting. Methods: We identified patients 40 years of age and older within the Center for International Blo…

Comparison of Characteristics and Outcomes of Trial Participants and Nonparticipants: Example of Blood and Marrow Transplant Clinical Trials Network 0201 Trial Open

Nandita Khera, Navneet S. Majhail, Ruta Brazauskas, Zhi-Wei Wang, Naya He , et al. · 2020

Controversy surrounds the question of whether clinical trial participants have better outcomes than comparable patients who are not treated on a trial. We explored this question using a recent large, randomized, multi-center study comparin…

Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis Open

Kira Bona, Ruta Brazauskas, Naya He, Leslie Lehmann, Hisham Abdel‐Azim , et al. · 2020

Social determinants of health, including poverty, contribute significantly to health outcomes in the United States; however, their impact on pediatric hematopoietic cell transplantation (HCT) outcomes is poorly understood. We aimed to iden…

Infections in Infants with SCID: Isolation, Infection Screening, and Prophylaxis in PIDTC Centers Open

Morna J. Dorsey, Nicola Wright, Natalia S. Chaimowitz, Blachy J. Dávila Saldaña, Holly Miller , et al. · 2020

Patient with Down syndrome and relapsed acute lymphoblastic leukemia with sustained remission despite only partial British R3 chemotherapy Open

Zhongbo Hu, Kristen A. VanHeyst, Jignesh Dalal, Lisa Hackney · 2020

DS-ALL patients have a higher rate of relapse and treatment-related mortality. We describe a DS-ALL patient with late bone marrow relapse who was treated per British ALL R3 reinduction chemotherapy. The patient remained in remission for ap…

Early transplant improves survival in chronic granulomatous disease: a report of the USIDNET Open

Jennifer R. Yonkof, Ashish O. Gupta, Pingfu Fu, Elizabeth Garabedian, Jignesh Dalal · 2020

Challenges in HLH transplant: Tricks to prevent menace of mixed chimerism Open

Zhongbo Hu, Jignesh Dalal · 2020

1 Division of Pediatric Hematology and Oncology, Department of Pediatrics, Rainbow Babies and Children’s Hospital, Case Western Reserve University, Cleveland, OH.* CorrespondenceJignesh Dalal, Pediatric Hematology Oncology, Rainbow Babies …

The Impact of Donor Type on Outcomes and Cost of Allogeneic Hematopoietic Cell Transplantation for Pediatric Leukemia: A Merged Center for International Blood and Marrow Transplant Research and Pediatric Health Information System Analysis Open

Staci D. Arnold, Ruta Brazauskas, Naya He, Yimei Li, Matt Hall , et al. · 2020

WISKOTT ALDRICH SYNDROME -- Is transplant a better option than supportive care? Open

Nikki Agarwal, Divyaswathi Citla Sridhar, Sindhoosha Malay, Nirav Patil, Sanjay Ahuja , et al. · 2020

Background : Wiskott Aldrich syndrome (WAS) is a rare disease and hematopoietic stem cell transplant (HCT) is considered the treatment modality of choice for WAS. Methods : We conducted a cross-sectional analysis on the Kids’ inpatient dat…

Patient with Down Syndrome and relapsed acute lymphoblastic leukemia with sustained remission despite only partial British R3 chemotherapy Open

Zhongbo Hu, Kristen A. VanHeyst, Jignesh Dalal, Lisa Hackney · 2020

Relapsed acute lymphoblastic leukemia (ALL) with high minimal residual disease (MRD) after reinduction has poor prognosis. ALL patients with Down syndrome (DS) have a higher rate of relapse and treatment related mortality. We describe a DS…

Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases Open

Staci D. Arnold, Ruta Brazauskas, Naya He, Yimei Li, Richard Aplenc , et al. · 2020

Advances in allogeneic hematopoietic cell transplantation for sickle cell disease have improved outcomes, but there is limited analysis of healthcare utilization in this setting. We hypothesized that, compared to late transplantation, earl…

Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions Open

Rajat Kumar, Fumihiko Kimura, Kwang Woo Ahn, Zhen‐Huan Hu, Yachiyo Kuwatsuka , et al. · 2020

Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared to mobilized peripheral blood stem cells (PBSC). We hypothesized that this recommendation may not ap…

Graft-versus-Host Disease after HLA-Matched Sibling Bone Marrow or Peripheral Blood Stem Cell Transplantation: Comparison of North American Caucasian and Japanese Populations Open

Junya Kanda, Ruta Brazauskas, Zhen‐Huan Hu, Yachiyo Kuwatsuka, Koji Nagafuji , et al. · 2020

The risk of acute graft-versus-host disease (GVHD) after HLA-matched sibling bone marrow (BM) transplantation is lower in Japanese than in Caucasian patients. However, race may have differential effect on GVHD dependent on the graft source…

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