Jieun Seo
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View article: Development and Performance Validation of a Comprehensive Liquid Biopsy Genotyping Panel for Pan-cancer Analysis
Development and Performance Validation of a Comprehensive Liquid Biopsy Genotyping Panel for Pan-cancer Analysis Open
The PAN100 panel is a robust tool for detecting clinically significant variants with high concordance with tissue NGS. Its sensitivity for low-frequency variants enables real-time treatment adaptation, supporting precision oncology. Its co…
View article: Dopamine D2 receptor modulation of insulin receptor signaling in the central amygdala: implications for compulsive-like eating behavior
Dopamine D2 receptor modulation of insulin receptor signaling in the central amygdala: implications for compulsive-like eating behavior Open
Compulsive eating behavior, characterized by the excessive intake of palatable high-sugar and high-fat foods despite negative consequences, may be associated with dysfunctional dopamine system, specifically involving the dopamine D2 recept…
View article: Towards understanding cancer dormancy over strategic hitching up mechanisms to technologies
Towards understanding cancer dormancy over strategic hitching up mechanisms to technologies Open
Delving into cancer dormancy has been an inherent task that may drive the lethal recurrence of cancer after primary tumor relief. Cells in quiescence can survive for a short or long term in silence, may undergo genetic or epigenetic change…
View article: Supplementary Data 1 from Investigation of poly ADP-ribose polymerase inhibitor resistance based on serially collected circulating tumor DNA in patients with <i>BRCA</i>-mutated ovarian cancer
Supplementary Data 1 from Investigation of poly ADP-ribose polymerase inhibitor resistance based on serially collected circulating tumor DNA in patients with <i>BRCA</i>-mutated ovarian cancer Open
Supplementary Methods Supplementary Figure 1-5 Supplementary Table 1-2
View article: Supplementary Data 1 from Investigation of poly ADP-ribose polymerase inhibitor resistance based on serially collected circulating tumor DNA in patients with <i>BRCA</i>-mutated ovarian cancer
Supplementary Data 1 from Investigation of poly ADP-ribose polymerase inhibitor resistance based on serially collected circulating tumor DNA in patients with <i>BRCA</i>-mutated ovarian cancer Open
Supplementary Methods Supplementary Figure 1-5 Supplementary Table 1-2
View article: Data from Investigation of poly ADP-ribose polymerase inhibitor resistance based on serially collected circulating tumor DNA in patients with <i>BRCA</i>-mutated ovarian cancer
Data from Investigation of poly ADP-ribose polymerase inhibitor resistance based on serially collected circulating tumor DNA in patients with <i>BRCA</i>-mutated ovarian cancer Open
Purpose: Patient-specific molecular alterations leading to poly ADP-ribose polymerase inhibitor (PARPi) resistance are relatively unexplored. In this study, we analyzed serially collected circulating tumor DNA (ctDNA) from patients with BR…
View article: Clinical Application of Optical Genome Mapping for Molecular Diagnosis of Facioscapulohumeral Muscular Dystrophy
Clinical Application of Optical Genome Mapping for Molecular Diagnosis of Facioscapulohumeral Muscular Dystrophy Open
OGM enables accurate and reliable detection of pathogenic contraction of the D4Z4-repeat array and is a valuable tool for the genetic diagnosis of FSHD1.
View article: Genotype Analysis of Respiratory Syncytial Virus Before and After the COVID-19 Pandemic Using Whole-Genome Sequencing: A Prospective, Single-Center Study in Korea From 2019 to 2022
Genotype Analysis of Respiratory Syncytial Virus Before and After the COVID-19 Pandemic Using Whole-Genome Sequencing: A Prospective, Single-Center Study in Korea From 2019 to 2022 Open
Despite the unprecedented interruption of RSV seasonality, there were no significant molecular changes in circulating RSV strains in Korea related to nirsevimab or palivizumab resistance before and after the COVID-19 pandemic. However, RSV…
View article: Supplementary Data 1 from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer
Supplementary Data 1 from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer Open
Supplementary MethodsSupplementary Figure 1-5Supplementary Table 1-2
View article: Data from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer
Data from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer Open
Purpose:Patient-specific molecular alterations leading to PARP inhibitor (PARPi) resistance are relatively unexplored. In this study, we analyzed serially collected circulating tumor DNA (ctDNA) from patients with BRCA1/2 mutations who rec…
View article: Supplementary Data 1 from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer
Supplementary Data 1 from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer Open
Supplementary MethodsSupplementary Figure 1-5Supplementary Table 1-2
View article: Data from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer
Data from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer Open
Purpose:Patient-specific molecular alterations leading to PARP inhibitor (PARPi) resistance are relatively unexplored. In this study, we analyzed serially collected circulating tumor DNA (ctDNA) from patients with BRCA1/2 mutations who rec…
View article: Data from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer
Data from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer Open
Purpose:Patient-specific molecular alterations leading to PARP inhibitor (PARPi) resistance are relatively unexplored. In this study, we analyzed serially collected circulating tumor DNA (ctDNA) from patients with BRCA1/2 mutations who rec…
View article: Supplementary Data 1 from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer
Supplementary Data 1 from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer Open
Supplementary Methods Supplementary Figure 1-5 Supplementary Table 1-2
View article: Supplementary Data 1 from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer
Supplementary Data 1 from Investigation of PARP Inhibitor Resistance Based on Serially Collected Circulating Tumor DNA in Patients With <i>BRCA</i>-Mutated Ovarian Cancer Open
Supplementary Methods Supplementary Figure 1-5 Supplementary Table 1-2
View article: Indole-3-acetic acid, a hormone potentially involved in chilling-induced seed browning of pepper (Capsicum annuum L.) fruit during cold storage
Indole-3-acetic acid, a hormone potentially involved in chilling-induced seed browning of pepper (Capsicum annuum L.) fruit during cold storage Open
Pepper (Capsicum annuum L.) fruit is affected by chilling temperatures below 7–10 °C; thus, there are limitations to maintaining postharvest freshness during its cold storage and distribution. Here, the six endogenous hormones, abscisic ac…
View article: The Genotype-Phenotype Correlation in Human 5α-Reductase Type 2 Deficiency: Classified and Analyzed from a SRD5A2 Structural Perspective
The Genotype-Phenotype Correlation in Human 5α-Reductase Type 2 Deficiency: Classified and Analyzed from a SRD5A2 Structural Perspective Open
The phenotype of the 5α-reductase type 2 deficiency (5αRD2) by the SRD5A2 gene mutation varies, and although there have been many attempts, the genotype-phenotype correlation still has not yet been adequately evaluated. Recently, the cryst…
View article: Analytical and Clinical Validation of Cell-Free Circulating Tumor DNA Assay for the Estimation of Tumor Mutational Burden
Analytical and Clinical Validation of Cell-Free Circulating Tumor DNA Assay for the Estimation of Tumor Mutational Burden Open
Background Ultra-deep sequencing to detect low-frequency mutations in circulating tumor-derived DNA (ctDNA) increases the diagnostic value of liquid biopsy. The demand for large ctDNA panels for comprehensive genomic profiling and tumor mu…
View article: Applications of molecular barcode sequencing for the detection of low‐frequency variants in circulating tumour <scp>DNA</scp> from hepatocellular carcinoma
Applications of molecular barcode sequencing for the detection of low‐frequency variants in circulating tumour <span>DNA</span> from hepatocellular carcinoma Open
Purpose Liquid biopsy has emerged as a promising tool for minimally invasive and accurate detection of various malignancies. We aimed to apply molecular barcode sequencing to circulating tumour DNA (ctDNA) from liquid biopsies of hepatocel…
View article: Uncovering the dosage-dependent roles of <i>Arid1a</i> in gastric tumorigenesis for combinatorial drug therapy
Uncovering the dosage-dependent roles of <i>Arid1a</i> in gastric tumorigenesis for combinatorial drug therapy Open
Gastric cancer (GC) is one of the most common deadly cancers in the world. Although patient genomic data have identified AT-rich interaction domain 1A (ARID1A), a key chromatin remodeling complex subunit, as the second most frequently muta…
View article: Chimerism Assay Using Single Nucleotide Polymorphisms Adjacent and in Linkage-Disequilibrium Enables Sensitive Disease Relapse Monitoring after Hematopoietic Stem-Cell Transplantation
Chimerism Assay Using Single Nucleotide Polymorphisms Adjacent and in Linkage-Disequilibrium Enables Sensitive Disease Relapse Monitoring after Hematopoietic Stem-Cell Transplantation Open
Background Short tandem repeat (STR)-based chimerism analysis has been widely used for chimerism monitoring after hematopoietic stem-cell transplantation (HSCT), but technical artifacts can be problematic. We designed a chimerism assay usi…
View article: Jasmonic acid and ERF family genes are involved in chilling sensitivity and seed browning of pepper fruit after harvest
Jasmonic acid and ERF family genes are involved in chilling sensitivity and seed browning of pepper fruit after harvest Open
Pepper ( Capsicum annuum L.) fruit is sensitive to temperatures below 10 °C, which severely diminish fruit quality during cold chain distribution. Seed browning was a major chilling symptom in 36 genotypes of C. annuum fruit screened after…
View article: Biallelic mutations in ABCB1 display recurrent reversible encephalopathy
Biallelic mutations in ABCB1 display recurrent reversible encephalopathy Open
The clinical phenotype linked with mutations in ABCB1, encoding P‐glycoprotein, has never been reported. Here, we describe twin sisters with biallelic mutations in ABCB1 who showed recurrent reversible encephalopathy accompanied by acute f…
View article: Comprehensive genetic analysis by whole exome sequencing in 352 Korean pediatric patients with unknown neurodevelopmental disorders
Comprehensive genetic analysis by whole exome sequencing in 352 Korean pediatric patients with unknown neurodevelopmental disorders Open
Importance Accurate diagnosis of pediatric patients with complicated neurological problems demands a well-coordinated combination of robust genetic analytic capability and delicate clinical evaluation. It should be tested whether this chal…
View article: A Permeation Characteristics Study of Water- or Oil-soluble Substances through Condition Setting for the In Vitro Skin Absorption Method
A Permeation Characteristics Study of Water- or Oil-soluble Substances through Condition Setting for the In Vitro Skin Absorption Method Open
Objectives: The purpose of this study was to compare permeation characteristics in three skin types using oil-soluble benzoic acid and water-soluble caffeine after method condition optimization based on OECD guideline 428. Methods: A Franz…
View article: Projection of future hot weather events and potential population exposure to this in South Korea
Projection of future hot weather events and potential population exposure to this in South Korea Open
CR Climate Research Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials CR 72:29-38 (2017) - DOI: https://doi.org/10.3354/cr01446 Projection of…