Abstract Aims The impact of social determinants of health (SDOH) on mental health is increasingly realized. A comprehensive study examining the associations of SDOH with mental health disorders has yet to be accomplished. This study evaluated the associations between five domains of SDOH and the SDOH summary score and mental health disorders in the United States. Methods We analyzed data from a diverse group of participants enrolled in the All of Us research programme, a research programme to gather data from one …

Abstract Background This systematic review and meta-analysis aimed to quantify the relationship between energy intake (EI) and physical activity (PA) during pregnancy and gestational weight gain (GWG) in randomized controlled trials (RCTs). Methods RCTs measuring EI and PA at least twice and total GWG during pregnancy were eligible. To synthesize PA measures reported on different scales, standardized mean change per day (SMC/day) were obtained by dividing the change in PA by the standard deviation of the change. W…

<title>Abstract</title> Background Citrus, a globally vital economic crop, faces severe challenges due to extreme climatic conditions and diseases/pests attack. <italic>Poncirus trifoliata</italic> is closely related to citrus and shows unique cold tolerance, making it a crucial material for unraveling genes involved in cold tolerance. NAC (NAM, ATAF1/2, CUC2) transcription factors play important roles in plant growth, development, and stress responses. However, their evolution patterns and regulatory networks in …

Homocysteine (Hcy) is an age-related risk factor for erectile dysfunction (ED), with enhanced vascular toxicity in middle-aged and elderly individuals. However, folate-based Hcy-lowering therapies have shown limited efficacy, necessitating a reevaluation of its age-dependent pathogenic mechanism. Here, we demonstrate that senescent endothelial cells exhibit heightened responsiveness of methionyl-tRNA synthetase 1 (MARS1) to Hcy, promoting the production of homocysteine thiolactone (HTL) and widespread N-homocystei…

Importance Understanding whether there are racial and ethnic and residential disparities in prenatal telehealth uptake is necessary for ensuring equitable access and guiding implementation of future hybrid (ie, both telehealth and in-person) prenatal care. Objective To assess temporal changes in individuals using hybrid prenatal care before and during the COVID-19 public health emergency (PHE) by race and ethnicity and residence location in the US. Design, Setting, and Participants This retrospective cohort study …