Jijing Chen
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View article: Reoviridae-derived short trimerization domain for stabilizing homo-trimerization of vaccine immunogens and therapeutic proteins
Reoviridae-derived short trimerization domain for stabilizing homo-trimerization of vaccine immunogens and therapeutic proteins Open
Trimerization motifs play pivotal roles in structural biology and therapeutic protein engineering. Here, we engineered a novel short trimerization motif (rFd1303) derived from the Reoviridae family reovirus σ1 protein. Compared with the wi…
View article: A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants
A quadri-fluorescence SARS-CoV-2 pseudovirus system for efficient antigenic characterization of multiple circulating variants Open
The ongoing co-circulation of multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strains necessitates advanced methods such as high-throughput multiplex pseudovirus systems for evaluating immune responses to different va…
View article: Discriminative non-destructive imaging of flip chips based on photoacoustic remote sensing microscopy with layered elasto-optic models
Discriminative non-destructive imaging of flip chips based on photoacoustic remote sensing microscopy with layered elasto-optic models Open
Discriminative internal imaging for different chip layers can pinpoint the location of critical defect in the flip chips, yet existing methods face challenges in in-line imaging to identify defects or structures from the sub-surface within…
View article: In-line imaging and recognition of flip chip fabrication defects by real-time photoacoustic remote sensing system
In-line imaging and recognition of flip chip fabrication defects by real-time photoacoustic remote sensing system Open
Microscopic defects in flip chips, originating from manufacturing, significantly affect performance and longevity. Post-fabrication sampling methods ensure product functionality but lack in-line defect monitoring to enhance chip yield and …
View article: Global climate regulates dimensions of terrestrial ecosystem stability
Global climate regulates dimensions of terrestrial ecosystem stability Open
Ecosystem stability represents the ability of the ecosystem to maintain and restore its functions. The indicators of ecosystem stability include temporal stability, resistance, and resilience, which are crucial parameters to predict the ba…
View article: Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus
Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus Open
Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A time…
View article: Development and validation of a simple tool composed of items on dyspnea, respiration rates, and C-reactive protein for pneumonia prediction among acute febrile respiratory illness patients in primary care settings
Development and validation of a simple tool composed of items on dyspnea, respiration rates, and C-reactive protein for pneumonia prediction among acute febrile respiratory illness patients in primary care settings Open
Background Acute febrile respiratory illness (AFRI) patients are susceptible to pneumonia and suffer from significant morbidity and mortality throughout the world. In primary care settings, the situation is worse. Limited by computerized t…
View article: Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants
Cross-species tropism and antigenic landscapes of circulating SARS-CoV-2 variants Open
Mutations in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike receptor-binding domain (RBD) may alter viral host tropism and affect the activities of neutralizing antibodies. Here, we investigated 153 RBD mutants and …
View article: Drought stress strengthens the link between chlorophyll fluorescence parameters and photosynthetic traits
Drought stress strengthens the link between chlorophyll fluorescence parameters and photosynthetic traits Open
Chlorophyll fluorescence (ChlF) has been used to understand photosynthesis and its response to climate change, particularly with satellite-based data. However, it remains unclear how the ChlF ratio and photosynthesis are linked at the leaf…
View article: Optofluidic microcapillary biosensor for label-free, low glucose concentration detection
Optofluidic microcapillary biosensor for label-free, low glucose concentration detection Open
We demonstrate label-free detection of low glucose concentration based on whispery gallery mode resonance in an optofluidic microcapillary (OFMC) biosensor. The wall surface of the OFMC is bio-chemically functionalized to detect cellular-l…