Explanipedia

Evaluating large language models in pediatric fever management: a two-layer study Open

Guijun Yang, Hui Jiang, Shuhua Yuan, Mingyu Tang, Jing Zhang , et al. · 2025

Background Pediatric fever is a prevalent concern, often causing parental anxiety and frequent medical consultations. While large language models (LLMs) such as ChatGPT, Perplexity, and YouChat show promise in enhancing medical communicati…

Qingfei Paidu Granules for SARS-CoV-2 Omicron variant infection in children: A randomized controlled trial Open

Jijun Li, Hongliang Dong, Mingyu Tang, Jilei Lin, Lan Li , et al. · 2025

Changes in lung function in children after pneumonia: a multicenter study Open

Hejun Jiang, Junming Dai, Guifang Zhou, Guijun Yang, Liwen Zhang , et al. · 2025

Enhancing pediatric asthma management in underdeveloped regions through ChatGPT training for doctors: a randomized controlled trial Open

Liwen Zhang, Guijun Yang, J. M. Yuan, Shuhua Yuan, Jing Zhang , et al. · 2025

Background Childhood asthma represents a significant challenge globally, especially in underdeveloped regions. Recent advancements in Large Language Models (LLMs), such as ChatGPT, offer promising improvements in medical service quality. M…

Global, regional and national burden of asthma from 1990 to 2021: a systematic analysis for the Global Burden of Disease Study 2021 Open

Liwen Zhang, Hejun Jiang, Guijun Yang, Jing Zhang, Shuhua Yuan , et al. · 2025

Background Asthma represents a significant global health challenge, exhibiting considerable variation in prevalence, incidence, mortality and disability-adjusted life years (DALYs) across regions and countries. This study evaluates global,…

Local and systemic cytokine profiles in children with pneumonia-associated lung consolidation Open

Jilei Lin, Jiande Chen, Shuhua Yuan, Mingyu Tang, Guijun Yang , et al. · 2025

Objective Lung consolidation (LC) in pediatric pneumonia could lead to complicated clinical outcomes, yet the underlying immunological mechanisms are not fully understood. This study aimed to investigate the roles of local and systemic cyt…

A clinician-based comparative study of large language models in answering medical questions: the case of asthma Open

Yong Yin, Mei Zeng, Hansong Wang, Haibo Yang, Chuxiong Zhou , et al. · 2025

Objective This study aims to evaluate and compare the performance of four major large language models (GPT-3.5, GPT-4.0, YouChat, and Perplexity) in answering 32 common asthma-related questions. Materials and methods Seventy-five clinician…

Local Versus Systemic Cytokine Dynamics in Pediatric Pneumonia Open

Jilei Lin, Mingyu Tang, Shuhua Yuan, Jiande Chen, Guijun Yang , et al. · 2025

No significant correlation was observed between most local and systemic cytokines in children with pneumonia. The observed elevation of specific cytokines such as IL‐2, IL‐2R, and IL‐4 in the BALF of pneumonia patients, alongside increases…

Active and Stable Platinum-Indium Single Atom Alloy Catalysts for Propane Dehydrogenation Open

Jilei Lin, Chunjuan Zhang, Sifeng Bi, Gurong Shen, Feng Gao , et al. · 2025

Active and Stable Platinum-Indium Single Atom Alloy Catalysts for Propane Dehydrogenation Open

Jilei Lin, Meiqing Shen, Chunjuan Zhang, Sifeng Bi, Gurong Shen , et al. · 2025

Imaging features and clinical evaluation of pulmonary nodules in children Open

Muheremu Dilimulati, Yuan Shu-hua, Hejun Jiang, Yahua Wang, Hui Ma , et al. · 2024

Background With the widespread use of computed tomography (CT), the detection rate of pulmonary nodules in children has gradually increased. Due to the lack of epidemiological evidence and clinical guideline on pulmonary nodule treatment i…

Exploring the prevalence and chest CT predictors of Long COVID in children: a comprehensive study from Shanghai and Linyi Open

Yong Yin, Guijun Yang, Na Wang, Mei Zeng, Hejun Jiang , et al. · 2024

Introduction COVID-19 constitutes a pandemic of significant detriment to human health. This study aimed to investigate the prevalence of Long COVID following SARS-CoV-2 infection, analyze the potential predictors of chest CT for the develo…

Association of obesity with osteoporotic fracture risk in individuals with bone metabolism-related conditions: a cross sectional analysis Open

Guijun Yang, Hejun Jiang, Dan Xie, Shuhua Yuan, Jinhong Wu , et al. · 2024

Introduction This study aimed to investigate the individual and composite associations of different indices of obesity on osteoporotic fractures at three different sites among individuals affected by conditions influencing bone metabolism.…

The correlation between selenium intake and lung function in asthmatic people: a cross-sectional study Open

Hejun Jiang, Guijun Yang, Jing Chen, Shuhua Yuan, Jinhong Wu , et al. · 2024

Objective This study aimed to examine the correlation between selenium intake and lung function in asthmatic people. Methods A total of 4,541 individuals in the US National Health and Nutrition Examination Survey (NHANES) were included in …

Allergic diseases aggravate the symptoms of SARS-CoV-2 infection in China Open

Huishan Zhang, Jilei Lin, Jinhong Wu, Jing Zhang, Lei Zhang , et al. · 2023

Background The relationship between allergic diseases and the adverse outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a subject of controversy. This study aimed to investigate the association bet…

Huashi baidu granule in the treatment of pediatric patients with mild coronavirus disease 2019: A single-center, open-label, parallel-group randomized controlled clinical trial Open

Jiande Chen, Qiuyu Tang, Baoqin Zhang, Shuhua Yuan, Jia Chen , et al. · 2023

Background: Since late February 2022, a wave of coronavirus disease 2019 (COVID-19) mainly caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant rapidly appeared in Shanghai, China. Traditional Chinese …

Prognosis of bronchial asthma in children with different pulmonary function phenotypes: A real-world retrospective observational study Open

Lu Liu, Hui Ma, Shuhua Yuan, Jing Zhang, Jinhong Wu , et al. · 2023

Objective To follow up on the changes in pulmonary function phenotypes in children with asthma in the first year after diagnosis, and explore the risk factors of poor control in children with good treatment compliance. Methods Children who…

Vitamin A–regulated ciliated cells promote airway epithelium repair in an asthma mouse model Open

Wen Tan, Jilei Lin, Yaping Wang, Yan Li, Linyan Ying , et al. · 2023

Background: Asthma is a chronic inflammatory airway disease that causes damage to and exfo-liation of the airway epithelium. The continuous damage to the airway epithelium in asthma cannot be repaired quickly and generates irreversible dam…

A prediction model for the efficacy of continuous positive airway pressure on bronchiolitis Open

Qingxia Shi, Zhihua Zhao, Jilei Lin, Yin Zhang, Jihong Dai · 2022

Objectives Prediction of the efficacy of continuous positive airway pressure (CPAP) on bronchiolitis is necessary for timely treatment. This study aims to establish a nomogram for efficacy of CPAP on bronchiolitis, and compares accuracy wi…

A booster shot of vaccine against SARS-CoV-2 should be rigorously promoted and implemented in China Open

Yong Yin, Jilei Lin, Shuhua Yuan, Shilu Tong, Erzhen Chen , et al. · 2022

The relationship between early isolation and the duration of viral shedding of mild and asymptomatic infection with SARS-CoV-2 Omicron BA.2 variant Open

Yong Yin, Jilei Lin, Shuhua Yuan, Shilu Tong, Erzhen Chen , et al. · 2022

Comparison of Pulmonary Function and Inflammation in Children/Adolescents with New-Onset Asthma with Different Adiposity Statuses Open

Xiaolan Ying, Jie Lin, Shuhua Yuan, Chunhong Pan, Wenfang Dong , et al. · 2022

(1) Background: The relationship between obesity and asthma is still uncertain. This study aimed to investigate the effect of overweight/obesity on the pulmonary function of patients with new-onset pediatric asthma and explore the possible…

Establishment of a Simple Pediatric Lower Respiratory Tract Infections Database Based on the Structured Electronic Medical Records Open

Jilei Lin, Shuhua Yuan, Dong Bin, Jing Zhang, Lei Zhang , et al. · 2022

Objective This study aimed to establish a pediatric lower respiratory tract infections (PLRTIs) database based on the structured electronic medical records (SEMRs), to provide a brief overview and the usage process of the SEMRs and the dat…

The Relationship Between Daily Dietary Intake of Fiber and Short Sleep Duration in the Presence of Di(2-Ethylhexyl) Phthalate: A Population-Based Study Open

Jilei Lin, Siying Cheng, Jing Zhang, Shuhua Yuan, Lei Zhang , et al. · 2022

Objective This study aimed to evaluate the relationship between daily dietary intake of fiber (DDIF) and short sleep duration (SSD) in the presence of di(2-ethylhexyl) phthalate. Methods Data of 13,634 participants in this study were colle…

The Association between Daily Dietary Intake of Riboflavin and Lung Function Impairment Related with Dibutyl Phthalate Exposure and the Possible Mechanism Open

Jilei Lin, Siying Cheng, Jing Zhang, Shuhua Yuan, Lei Zhang , et al. · 2022

This study aimed to evaluate the relationship between the daily dietary intake of riboflavin (DDIR) and impaired lung function associated with dibutyl phthalate (DBP) exposure. Data of 4631 adults in this national cross-sectional survey we…

Evaluation of the Clinical Effectiveness of Oseltamivir for Influenza Treatment in Children Open

Jianru Qin, Jilei Lin, Xiangfei Zhang, Shuhua Yuan, Chiyu Zhang , et al. · 2022

Objective: To estimate the clinical effectiveness of oseltamivir in children with different subtypes of influenza virus infection. Methods: A total of 998 children with acute respiratory infection were enrolled from January to March 2018, …

Andrographolide attenuates RSV-induced inflammation by suppressing apoptosis and promoting pyroptosis after respiratory syncytial virus infection in vitro Open

Siyi Che, Xiaohong Xie, Jilei Lin, Ying Liu, Jun Xie , et al. · 2022

Respiratory syncytial virus (RSV), the most common viral pathogen causing acute lower respiratory tract infection among children under five years old worldwide, still lacks specific therapeutic drugs. Andrographolide has been found efficac…

The Associations of Caesarean Delivery With Risk of Wheezing Diseases and Changes of T Cells in Children Open

Jilei Lin, Shuhua Yuan, Bin Dong, Jing Zhang, Lei Zhang , et al. · 2021

Objectives This study aimed to assess the associations of caesarean delivery (CD) with risk of wheezing diseases and changes of immune cells in children. Design The cross-sectional study was conducted between May, 2020 and April, 2021. Set…

The Association Between Variability in Electrolytes and the In-Hospital Mortality in Critically Ill Children in Pediatric Intensive Care Units Open

Jilei Lin, Yin Zhang, Meng Chen, Jihong Dai, Anchao Song , et al. · 2021

Objective: This study aimed to explore the association between the variability in electrolytes and the in-hospital mortality in critically ill children admitted into intensive care units (ICUs). Design: This is a retrospective case–control…

Establishing a patient registry study database of dust mite allergic asthma in children: design, methodology and preliminary exploration Open

Juan Zhou, Weiguo Li, Xiang Wen, Dan Zeng, Jilei Lin , et al. · 2021

We have preliminarily established a registered study database of children with DMAA. By cluster analysis and using blood samples, we can further study the different pathophysiological mechanisms in order to provide more individualized and …

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