Jill J. Hauer
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View article: Bruch’s membrane heparan sulfate retains lipoproteins in the early stages of age-related macular degeneration
Bruch’s membrane heparan sulfate retains lipoproteins in the early stages of age-related macular degeneration Open
Lipoprotein retention in Bruch’s membrane is a key event in the pathobiology of early and intermediate age-related macular degeneration (AMD). However, the mechanism of lipoprotein retention in BrM is unknown. Given the established role of…
View article: Defining Nephritic Factors as Diverse Drivers of Systemic Complement Dysregulation in C3 Glomerulopathy
Defining Nephritic Factors as Diverse Drivers of Systemic Complement Dysregulation in C3 Glomerulopathy Open
This study implicates complement autoantibodies as robust drivers of systemic complement dysregulation in approximately 50% of C3G but also highlights the need for continued discovery-based research to identify novel drivers of disease.
View article: <scp>C3</scp> glomerulopathy: Understanding an ultra‐rare complement‐mediated renal disease
<span>C3</span> glomerulopathy: Understanding an ultra‐rare complement‐mediated renal disease Open
C3 glomerulopathy (C3G) describes a pathologic pattern of injury diagnosed by renal biopsy. It is characterized by the dominant deposition of the third component of complement (C3) in the renal glomerulus as resolved by immunofluorescence …
View article: Results from a nationwide retrospective cohort measure the impact of C3 and soluble C5b-9 levels on kidney outcomes in C3 glomerulopathy
Results from a nationwide retrospective cohort measure the impact of C3 and soluble C5b-9 levels on kidney outcomes in C3 glomerulopathy Open
View article: POS-017 A POPULATION PERSPECTIVE OF NEPHRITIC FACTORS AS SYSTEMIC DRIVERS OF COMPLEMENT DYSREGULATION IN C3 GLOMERULOPATHY
POS-017 A POPULATION PERSPECTIVE OF NEPHRITIC FACTORS AS SYSTEMIC DRIVERS OF COMPLEMENT DYSREGULATION IN C3 GLOMERULOPATHY Open
IntroductionC3 Glomerulopathy (C3G) is an ultra-rare renal disease mediated by dysregulation of the alternative pathway (AP) of the complement system. Rare and novel genetic variation in complement genes and autoantibodies to complement pr…
View article: Factor B and C4b2a Autoantibodies in C3 Glomerulopathy
Factor B and C4b2a Autoantibodies in C3 Glomerulopathy Open
C3 Glomerulopathy (C3G) is a renal disease mediated primarily by dysregulation of the alternative pathway of complement. Complement is the cornerstone of innate immunity. It targets infectious microbes for destruction, clears immune comple…
View article: High-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 Glomerulopathies
High-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 Glomerulopathies Open
The thrombotic microangiopathies (TMAs) and C3 glomerulopathies (C3Gs) include a spectrum of rare diseases such as atypical hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, C3GN, and dense deposit disease, which share phenot…