Explanipedia

Modelling cigarette smoke-induced lung vascular dysfunction using an alveolus-on-chip Open

Abilash Ravi, Tarek Gensheimer, Xinhui Wu, Jill R. Johnson, Martin C. Harmsen , et al. · 2025

The alveolus is central to gas exchange in the lung, and alveolar damage is a characteristics of a variety of lung diseases. Understanding alveolar microvascular dynamics and epithelial-endothelial interactions is essential for accurately …

A Breath of Fresh Insight: Targeting CXCR4 in Early COPD Open

R.E. Bignold, Jill R. Johnson · 2025

Abstract 2369 Quantitative Proteomics of Mutations in Yeast Hsp90 and Cdc37 Reveal Client Specific Effects Open

Erick Rios, Jill R. Johnson · 2025

Biologic therapies targeting type 2 cytokines are effective at improving asthma symptoms and control—a systematic review and meta-analysis Open

R.E. Bignold, H K Busby, John W. Holloway, Aaishah Kasu, Shirley Sian , et al. · 2024

Pericytes: The lung-forgotten cell type Open

Annelise T. Garrison, R.E. Bignold, Xinhui Wu, Jill R. Johnson · 2023

Pericytes are a heterogeneous population of mesenchymal cells located on the abluminal surface of microvessels, where they provide structural and biochemical support. Pericytes have been implicated in numerous lung diseases including pulmo…

Abstract 1446: A proteomic approach to determining whether temperature-sensitive yeast Hsp90 alleles that exhibit similar growth defects have differing effects on client proteins Open

Jill R. Johnson, Erick Rios · 2023

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease Open

R.E. Bignold, Bushra Shammout, Jessica E. Rowley, Mariaelena Repici, John Simms , et al. · 2022

CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease Open

R.E. Bignold, Bushra Shammout, Jessica E. Rowley, Mariaelena Repici, John Simms , et al. · 2022

Background Airway remodeling is a significant contributor to impaired lung function in chronic allergic airway disease. Currently, no therapy exists that is capable of targeting these structural changes and the consequent loss of function.…

Drivers of Type 2 Inflammation in Allergic Airway Disease: Wnt You Like to Know? Open

Xinhui Wu, Jill R. Johnson · 2022

molecular mechanisms regulating macrophage polarization and the downstream effects of these pathways on other immune and structural cell types is essential to clarify the relationship between allergen exposure, macrophage activity, and the…

Matricellular Protein Periostin Promotes Pericyte Migration in Fibrotic Airways Open

R.E. Bignold, Jill R. Johnson · 2021

Introduction: Periostin is a matricellular protein that is currently used as a biomarker for asthma. However, its contribution to tissue remodeling in allergic asthma is currently unknown. We have previously demonstrated that tissue-reside…

Macrophages: The Good, the Bad, and the Gluttony Open

Ewan A. Ross, Andrew Devitt, Jill R. Johnson · 2021

Macrophages are dynamic cells that play critical roles in the induction and resolution of sterile inflammation. In this review, we will compile and interpret recent findings on the plasticity of macrophages and how these cells contribute t…

Inflammation-Induced Pericyte Dysfunction Is Abrogated by Interfering with the CXCL12/CXCR4 Signaling Pathway Open

Jill R. Johnson, Bushra Shammout · 2021

Periostin Expression Is Elevated in HDM-Driven Allergic Airway Disease and Associated with Increased Pericyte Migration Open

Jill R. Johnson, R.E. Bignold · 2021

RATIONALE: Pericytes are a type of tissue-resident mesenchymal stem cell that have been shown to contribute to tissue remodelling and fibrosis.In allergic asthma, pericytes achieve this by uncoupling and migrating away from blood vessels t…

Implementing Best Practice in Training Problem-Based Learning Tutors Open

Jill R. Johnson · 2021

Purpose In order to implement problem-based learning (PBL), extensive staff training is required. The purpose of this study was to qualitatively evaluate the efficacy of a training programme for inexperienced PBL tutors. Methods Data inclu…

Effects of cytokine signaling inhibition on inflammation-driven tissue remodeling Open

R.E. Bignold, Jill R. Johnson · 2021

Physical frailty predicts liver transplant waiting list mortality: United Kingdom experience Open

Felicity Williams, Alice Freer, Florence Hockey, Natasza Klas, Jonathan I. Quinlan , et al. · 2020

Modelling Fibrosis via Three Dimensional Pericyte-Endothelial Cell Coculture Using Biocompatible Nanoparticle Assembly and Spheroid Bioprinting Identifies Novel Therapeutic Targets Open

Bushra Shammout, Jill R. Johnson · 2020

The Applicability of Mouse Models to the Study of Human Disease Open

Kristina Rydell‐Törmänen, Jill R. Johnson · 2019

Pericytes, mesenchymal stem cells and their contributions to tissue repair Open

Suet‐Ping Wong, Jessica E. Rowley, Andia N. Redpath, Jessica Tilman, Tariq G. Fellous , et al. · 2015

Pericytes contribute to airway remodeling in a mouse model of chronic allergic asthma Open

Jill R. Johnson, Erika Folestad, Jessica E. Rowley, Elisa M. Noll, Simone A. Walker , et al. · 2015

Myofibroblast accumulation, subepithelial fibrosis, and vascular remodeling are complicating features of chronic asthma, but the mechanisms are not clear. Platelet-derived growth factors (PDGFs) regulate the fate and function of various me…

Acupuncture Provides Short-Term Pain Relief for Patients in a Total Joint Replacement Program Open

Daniel Crespin, Kristen H. Griffin, Jill R. Johnson, Cynthia Miller, Michael Finch , et al. · 2015

Acupuncture may be a viable adjunct to pharmacological approaches for pain management after THR or TKR.

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