Explanipedia

Skeletal Muscle Transcriptome Alterations Related to Declining Physical Function in Older Mice Open

Ted G. Graber, Rosario Maroto, Jill K. Thompson, Steven G. Widen, Zhaohui Man , et al. · 2025

One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differe…

Skeletal Muscle Transcriptome Alterations Related to Declining Physical Function in Older Mice Open

Ted G. Graber, Rosario Maroto, Jill K. Thompson, Steven G. Widen, Zhaohui Man , et al. · 2023

One inevitable consequence of aging is the gradual deterioration of physical function and exercise capacity, driven in part by the adverse effect of age on muscle tissue. We hypothesized that relationships exist between age-related differe…

Differences in Genetic Diversity of Mammalian Tick-Borne Flaviviruses Open

Kassandra L. Carpio, Jill K. Thompson, Steven G. Widen, Jennifer K. Smith, Terry L. Juelich , et al. · 2023

The genetic diversities of mammalian tick-borne flaviviruses are poorly understood. We used next-generation sequencing (NGS) to deep sequence different viruses and strains belonging to this group of flaviviruses, including Central European…

Genetic Diversity Does Not Contribute to Attenuation of HeLa Passaged Wild-Type Yellow Fever Virus Strain French Viscerotropic Virus Open

Ashley E. Strother, Jill K. Thompson, Steven G. Widen, Alan D.T. Barrett · 2022

The disease yellow fever was prevented by two live attenuated vaccines, strains 17D and French neurotropic vaccine (FNV), derived by serial passage of wild-type (WT) strains Asibi and French Viscerotropic virus (FVV), respectively. Both 17…

Japanese encephalitis virus live attenuated vaccine strains display altered immunogenicity, virulence and genetic diversity Open

Emily H. Davis, Andrew S. Beck, Li Li, Mellodee White, M. Banks Greenberg , et al. · 2021

Genome Characterization of Yellow Fever Virus Wild-Type Strain Asibi, Parent to Live-Attenuated 17D Vaccine, from Three Different Sources Open

Emily H. Davis, Jill K. Thompson, Steven G. Widen, Alan D.T. Barrett · 2021

The yellow fever virus vaccine, 17D, was derived through the serial passage of the wild-type (WT) strain Asibi virus in mouse and chicken tissue. Since its derivation, the mechanism of attenuation of 17D virus has been investigated using t…

Attenuation of Live-Attenuated Yellow Fever 17D Vaccine Virus Is Localized to a High-Fidelity Replication Complex Open

Emily H. Davis, Andrew S. Beck, Ashley E. Strother, Jill K. Thompson, Steven G. Widen , et al. · 2019

Live-attenuated viral vaccines are highly safe and efficacious but represent complex and often multigenic attenuation mechanisms. Most of these vaccines have been generated empirically by serial passaging of a wild-type (WT) virus in cell …

Analysis By Deep Sequencing of Discontinued Neurotropic Yellow Fever Vaccine Strains Open

Andrew S. Beck, Thomas G. Wood, Steven G. Widen, Jill K. Thompson, Alan D.T. Barrett · 2018

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