Jillian F. Armenia
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View article: Recurrent DNA nicks drive massive expansions of (GAA) <sub>n</sub> repeats
Recurrent DNA nicks drive massive expansions of (GAA) <sub>n</sub> repeats Open
Over 50 hereditary degenerative disorders are caused by expansions of short tandem DNA repeats (STRs). (GAA) n repeat expansions are responsible for Friedreich’s ataxia as well as late-onset cerebellar ataxias (LOCAs). Thus, the mechanisms…
View article: DNA Nicks Drive Massive Expansions of (GAA)<sub>n</sub>Repeats
DNA Nicks Drive Massive Expansions of (GAA)<sub>n</sub>Repeats Open
Over 50 hereditary degenerative disorders are caused by expansions of short tandem DNA repeats (STRs). (GAA) n repeat expansions are responsible for Friedreich’s ataxia as well as late-onset cerebellar ataxias (LOCAs). Thus, the mechanisms…
View article: Large-scale contractions of Friedreich’s ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability
Large-scale contractions of Friedreich’s ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability Open
Significance Expansions of GAA repeats cause a severe hereditary neurodegenerative disease, Friedreich’s ataxia. In this study, we characterized the mechanisms of GAA repeat contractions in a yeast experimental system. These mechanisms mig…