Jillian Losh
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View article: Microbial signals in primary and metastatic brain tumors
Microbial signals in primary and metastatic brain tumors Open
Gliomas and brain metastases are associated with poor prognosis, necessitating a deeper understanding of brain tumor biology and the development of effective therapeutic strategies. Although our group and others have demonstrated microbial…
View article: Intra-tumoral bacterial signals are associated with distinct immune niches in metastatic brain tumors 3692
Intra-tumoral bacterial signals are associated with distinct immune niches in metastatic brain tumors 3692 Open
Description Metastatic brain tumors (BrM) are associated with significant morbidity and mortality. Despite significant advances in understanding the role of microbiome in cancer and tumor immunity, the impact of microbiome in BrM remains l…
View article: BSBM-06 SINGLE-CELL SPATIAL ANALYSIS OF METASTATIC BRAIN TUMORS REVEALS INTRACELLULAR BACTERIAL SIGNAL AND THEIR CORRELATION WITH THE TUMOR MICROENVIRONMENT
BSBM-06 SINGLE-CELL SPATIAL ANALYSIS OF METASTATIC BRAIN TUMORS REVEALS INTRACELLULAR BACTERIAL SIGNAL AND THEIR CORRELATION WITH THE TUMOR MICROENVIRONMENT Open
Metastatic brain tumors are associated with significant morbidity and mortality. Recent trials have demonstrated the potential efficacy of immunotherapy for the management of brain metastasis (BrM), albeit in only a subset of patients. Und…
View article: Young-onset Rectal Cancer
Young-onset Rectal Cancer Open
Objective: External exposures, the host, and the microbiome interact in oncology. We aimed to investigate tumoral microbiomes in young-onset rectal cancers (YORCs) for profiles potentially correlative with disease etiology and biology. Bac…
View article: Identifying Subunit Organization and Function of the Nuclear RNA Exosome Machinery
Identifying Subunit Organization and Function of the Nuclear RNA Exosome Machinery Open
IDENTIFYING SUBUNIT ORGANIZATION AND FUNCTION OF THE NUCLEAR RNA EXOSOME MACHINERY \nJillian Strother Losh, A.S., B.S. \nThe eukaryotic RNA exosome processes and degrades many classes of RNA. It is present in the nucleus and the cytoplasm,…
View article: Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast
Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast Open
Pontocerebellar hypoplasia type 1b (PCH1b) is an autosomal recessive disorder that causes cerebellar hypoplasia and spinal motor neuron degeneration, leading to mortality in early childhood. PCH1b is caused by mutations in the RNA exosome …
View article: Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing
Interaction between the RNA-dependent ATPase and poly(A) polymerase subunits of the TRAMP complex is mediated by short peptides and important for snoRNA processing Open
The RNA exosome is one of the main 3′ to 5′ exoribonucleases in eukaryotic cells. Although it is responsible for degradation or processing of a wide variety of substrate RNAs, it is very specific and distinguishes between substrate and non…