Jillian R. Brown
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View article: Low Iodine Status in a Large Pregnancy Cohort in Ireland
Low Iodine Status in a Large Pregnancy Cohort in Ireland Open
Background: Iodine is an essential component of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), which are required for brain development [...]
View article: Low Maternal Iodine Status in Early Pregnancy Is Associated with Cognitive and Language Delays at 24 Months in Non-Users of Nutritional Supplements
Low Maternal Iodine Status in Early Pregnancy Is Associated with Cognitive and Language Delays at 24 Months in Non-Users of Nutritional Supplements Open
Background: Severe maternal iodine deficiency has profound consequences for the developing brain; however, the impact of mild to moderate deficiency is less clear, and findings from observational studies have been mixed. Aim: The purpose o…
View article: Microbially-derived short-chain fatty acids impact astrocyte gene expression in a sex-specific manner
Microbially-derived short-chain fatty acids impact astrocyte gene expression in a sex-specific manner Open
Recent investigations in neuroscience implicate the role of microbial-derived metabolites, such as short-chain fatty acids (SCFAs) in brain health and disease. The SCFAs acetate, propionate and butyrate have pleiotropic effects within the …
View article: Identifying a biological signature of prenatal maternal stress
Identifying a biological signature of prenatal maternal stress Open
Psychological stress affects maternal gastrointestinal (GI) permeability, leading to low-grade inflammation, which can negatively affect fetal development. We investigated a panel of circulating markers as a biological signature of this st…
View article: Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B
Translational studies of intravenous and intracerebroventricular routes of administration for CNS cellular biodistribution for BMN 250, an enzyme replacement therapy for the treatment of Sanfilippo type B Open
View article: Evaluation of non-reducing end pathologic glycosaminoglycan detection method for monitoring therapeutic response to enzyme replacement therapy in human mucopolysaccharidosis I
Evaluation of non-reducing end pathologic glycosaminoglycan detection method for monitoring therapeutic response to enzyme replacement therapy in human mucopolysaccharidosis I Open
View article: Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity
Prebiotic supplementation in frail older people affects specific gut microbiota taxa but not global diversity Open
View article: Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection
Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection Open
View article: Additional file 3: of Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection
Additional file 3: of Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection Open
Table S7. Genes associated with archaeal metabolism obtained from shotgun metagenomic sequencing (XLS 24Â kb)
View article: Additional file 2: of Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection
Additional file 2: of Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection Open
Table S6. Taxonomic count of shotgun data for this study. (XLSX 19Â kb)
View article: Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain
Guanidinylated Neomycin Conjugation Enhances Intranasal Enzyme Replacement in the Brain Open
Iduronidase (IDUA)-deficient mice accumulate glycosaminoglycans in cells and tissues and exhibit many of the same neuropathological symptoms of patients suffering from Mucopolysaccharidosis I. Intravenous enzyme-replacement therapy for Muc…
View article: Effect of room temperature transport vials on DNA quality and phylogenetic composition of faecal microbiota of elderly adults and infants
Effect of room temperature transport vials on DNA quality and phylogenetic composition of faecal microbiota of elderly adults and infants Open
The commercial storage vials appear to be suitable for high diversity microbiota samples, but may be less appropriate for lower diversity samples. Differences between fresh and stored samples mean that where storage is unavoidable, a consi…