Jim Lewsey
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View article: Neutrophil-to-Lymphocyte Ratio and Mortality in Cardiovascular Disease or Cancer
Neutrophil-to-Lymphocyte Ratio and Mortality in Cardiovascular Disease or Cancer Open
View article: The impact of later trading hours for bars and clubs on alcohol-related ambulance call-outs and crimes in Scotland: a controlled interrupted time series study
The impact of later trading hours for bars and clubs on alcohol-related ambulance call-outs and crimes in Scotland: a controlled interrupted time series study Open
Background Alcohol-related harms are prevalent late at night, especially on weekends, when high levels of intoxication contribute to increased rates of injury and violence. Reducing or increasing alcohol trading hours late at night in bars…
View article: Transition towards healthcare ‘net zero’: modelling condition-specific patient travel carbon emission estimations by transport mode in a retrospective population-based cohort study, Greater Glasgow, UK
Transition towards healthcare ‘net zero’: modelling condition-specific patient travel carbon emission estimations by transport mode in a retrospective population-based cohort study, Greater Glasgow, UK Open
Objectives To estimate condition-specific patient travel distances and associated carbon emissions across common chronic diseases in routine National Health Service (NHS) care, and to assess the potential carbon savings of modal shifts in …
View article: Measuring individual and community capacity factors in people with multimorbidity and exploring associations with health outcomes
Measuring individual and community capacity factors in people with multimorbidity and exploring associations with health outcomes Open
View article: Association Between Long-Term Testosterone Exposure and Major Adverse Cardiovascular Events in Aging Men
Association Between Long-Term Testosterone Exposure and Major Adverse Cardiovascular Events in Aging Men Open
Context Hypogonadism is a common endocrine disorder in aging men, associated with adverse cardiometabolic outcomes. Concerns about the cardiovascular (CV) safety of testosterone, an important therapy option for the condition, may be dispro…
View article: Does the frailty index applied to randomised controlled trials really measure frailty?
Does the frailty index applied to randomised controlled trials really measure frailty? Open
Background Cumulative deficit frailty indices from randomised controlled trials (RCT) are increasingly used to assess whether trial findings are applicable to people living with frailty. The aim of this paper was to examine the range and t…
View article: 7-019 Evolving burden of cardiovascular disease in the West of Scotland
7-019 Evolving burden of cardiovascular disease in the West of Scotland Open
View article: Evaluating the impact of the increase in funding entitlement to Early Learning and Childcare from 600 to 1140 hours per year on family wellbeing in Scotland: statistical analysis plan
Evaluating the impact of the increase in funding entitlement to Early Learning and Childcare from 600 to 1140 hours per year on family wellbeing in Scotland: statistical analysis plan Open
This report provides the statistical analysis plan (SAP) for a study evaluating the impact of the increase in funding entitlement to Early Learning and Childcare from 600 to 1140 hours per year on family wellbeing in Scotland. In order to …
View article: Association of sociodemographic factors and comorbidity with non-receipt of medications for secondary prevention: a cohort study of 12,204 myocardial infarction survivors
Association of sociodemographic factors and comorbidity with non-receipt of medications for secondary prevention: a cohort study of 12,204 myocardial infarction survivors Open
View article: Policy models for preventative interventions in cardiometabolic diseases: a systematic review
Policy models for preventative interventions in cardiometabolic diseases: a systematic review Open
View article: Protocol for an economic evaluation alongside a natural experiment to evaluate the impact of later trading hours for bars and clubs in the night-time economy in Scotland: The ELEPHANT study
Protocol for an economic evaluation alongside a natural experiment to evaluate the impact of later trading hours for bars and clubs in the night-time economy in Scotland: The ELEPHANT study Open
Introduction The night-time economy comprises various sectors, including hospitality, transportation and entertainment, which generate substantial revenues and contribute to employment opportunities. Furthermore, the night-time economy pro…
View article: Using natural experiments to evaluate population health and health system interventions: new framework for producers and users of evidence
Using natural experiments to evaluate population health and health system interventions: new framework for producers and users of evidence Open
Natural experiments are widely used to evaluate the impacts on health of changes in policies, infrastructure, and services. The UK Medical Research Council (MRC) and National Institute for Health and Care Research (NIHR) have published a n…
View article: Analysis of the kidney failure risk equation implementation in routine clinical practice and health inequalities in chronic kidney disease care: a retrospective cohort study
Analysis of the kidney failure risk equation implementation in routine clinical practice and health inequalities in chronic kidney disease care: a retrospective cohort study Open
View article: Using natural experiments to evaluate population health interventions: a framework for producers and users of evidence
Using natural experiments to evaluate population health interventions: a framework for producers and users of evidence Open
Background There has been a substantial increase in the conduct of natural experimental evaluations in the last 10 years. This has been driven by advances in methodology, greater availability of large routinely collected datasets, and a ri…
View article: Investigating causal effects of income on health using two-sample Mendelian randomisation
Investigating causal effects of income on health using two-sample Mendelian randomisation Open
Background Income is associated with many health outcomes, but it is unclear how far this reflects a causal relationship. Mendelian randomisation (MR) uses genetic variation between individuals to investigate causal effects and may overcom…
View article: Age and Sex Differences in Efficacy of Treatments for Type 2 Diabetes
Age and Sex Differences in Efficacy of Treatments for Type 2 Diabetes Open
Importance Sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and dipeptidyl peptidase 4 (DPP4) inhibitors improve hyperglycemia, and SGLT2 inhibitors and GLP-1 receptor agonists reduce th…
View article: Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts
Multimorbidity clusters and their associations with health-related quality of life in two UK cohorts Open
Background Identifying clusters of multiple long-term conditions (MLTCs), also known as multimorbidity, and their associated burden may facilitate the development of effective and cost-effective targeted healthcare strategies. This study a…
View article: Secular trends in types of cardiovascular disease in the West of Scotland
Secular trends in types of cardiovascular disease in the West of Scotland Open
Objective Historical reductions in cardiovascular disease (CVD) due to lifestyle and treatment improvements are now threatened by factors such as increasing obesity and diabetes, but the relative importance of different risk factors varies…
View article: Cancer diagnosis after emergency presentation: impact of demographics, cancer types, and pandemic
Cancer diagnosis after emergency presentation: impact of demographics, cancer types, and pandemic Open
Importance: Cancer diagnosis following an emergency department presentation (unscheduled care) is associated with lower cancer survival and poor patient-reported outcomes. Previous research has suggested considerable heterogeneity in cance…
View article: Correction: The conceptualisation of cardiometabolic disease policy model in the UK
Correction: The conceptualisation of cardiometabolic disease policy model in the UK Open
View article: Maternal and pregnancy factors contributing to the association between area deprivation and infant mortality in England: a retrospective cohort study
Maternal and pregnancy factors contributing to the association between area deprivation and infant mortality in England: a retrospective cohort study Open
UK Medical Research Council, Scottish Chief Scientist Office, Wellcome Trust.
View article: The conceptualisation of cardiometabolic disease policy model in the UK
The conceptualisation of cardiometabolic disease policy model in the UK Open
View article: Estimating natural history of a treatment-eligible type 2 diabetes mellitus population in Scotland using linked primary and secondary care data: Scottish Diabetes Research Network - National Diabetes Dataset
Estimating natural history of a treatment-eligible type 2 diabetes mellitus population in Scotland using linked primary and secondary care data: Scottish Diabetes Research Network - National Diabetes Dataset Open
Healthcare commissioners and those making reimbursement decisions require data on the “natural history” of diseases to estimate quantities such as life expectancy and quality of life. However, such data are commonly acquired from unreprese…
View article: Association of latent class analysis-derived multimorbidity clusters with adverse health outcomes in patients with multiple long-term conditions: comparative results across three UK cohorts
Association of latent class analysis-derived multimorbidity clusters with adverse health outcomes in patients with multiple long-term conditions: comparative results across three UK cohorts Open
View article: Estimating the causal effects of income on health: how researchers’ definitions of “income” matter
Estimating the causal effects of income on health: how researchers’ definitions of “income” matter Open
Background There is a well-established cross-sectional association between income and health, but estimates of the causal effects of income vary substantially. Different definitions of income may lead to substantially different empirical r…
View article: Loop diuretic therapy with or without heart failure: impact on prognosis
Loop diuretic therapy with or without heart failure: impact on prognosis Open
Background and Aims Many patients are prescribed loop diuretics without a diagnostic record of heart failure. Little is known about their characteristics and prognosis. Methods Glasgow regional health records (2009–16) were obtained for ad…
View article: Evaluating later or expanded premises hours for alcohol in the night-time economy (ELEPHANT): statistical analysis plan
Evaluating later or expanded premises hours for alcohol in the night-time economy (ELEPHANT): statistical analysis plan Open
This document provides the statistical analysis plan (SAP) for the ELEPHANT study (Evaluating later or expanded premises hours for alcohol in the night-time economy), an interrupted time series study following a natural experiment design, …
View article: Evaluating the impact of minimum unit pricing (MUP) on alcohol sales after 3 years of implementation in Scotland: A controlled interrupted time‐series study
Evaluating the impact of minimum unit pricing (MUP) on alcohol sales after 3 years of implementation in Scotland: A controlled interrupted time‐series study Open
Background and aims On 1 May 2018, Scotland introduced minimum unit pricing (MUP), a strength‐based floor price below which alcohol cannot be sold, throughout all alcoholic beverages. The legislation necessitates an evaluation of its impac…
View article: Pharmacological treatments for alcohol dependence: Evidence on uptake, inequalities and comparative effectiveness from a <scp>UK</scp> population‐based cohort
Pharmacological treatments for alcohol dependence: Evidence on uptake, inequalities and comparative effectiveness from a <span>UK</span> population‐based cohort Open
Introduction We assessed the prevalence of prescribing of certain medications for alcohol dependence and the extent of any inequalities in receiving prescriptions for individuals with such a diagnosis. Further, we compared the effectivenes…
View article: Issue Information
Issue Information Open
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