Ji Young Mun
YOU?
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View article: Correlative x-ray microscopy and transmission electron microscopy for ultrastructural analysis of zebrafish tissue
Correlative x-ray microscopy and transmission electron microscopy for ultrastructural analysis of zebrafish tissue Open
We established a correlative workflow combining X-ray microscopy (XRM) and transmission electron microscopy (TEM) to investigate the ultrastructure of zebrafish neuromasts. Zebrafish tissues were processed using conventional TEM embedding …
View article: VPS13B recruits lipid vesicles to promote mitochondrial fission and quality control
VPS13B recruits lipid vesicles to promote mitochondrial fission and quality control Open
Mutations in the gene VPS13B, which encodes a Golgi-associated protein, cause the neurodevelopmental disorder Cohen syndrome, but the protein's function is unclear. Here we show that this protein is essential for mitochondrial morphology a…
View article: Harnessing theta-gamma coupled brainwaves using ultrasound for spinal astrocyte revitalization and sustained neuropathic pain relief in mice
Harnessing theta-gamma coupled brainwaves using ultrasound for spinal astrocyte revitalization and sustained neuropathic pain relief in mice Open
Ultrasound stimulation is a promising non-invasive strategy for neuropathic pain, yet its sustained effects and underlying mechanisms remain poorly understood. We investigated brainwave-patterned low-intensity continuous theta-burst ultras…
View article: Development and immunogenicity of adenoviral Fc-fused FMDV virus-like particle vaccine in swine
Development and immunogenicity of adenoviral Fc-fused FMDV virus-like particle vaccine in swine Open
Foot-and-mouth disease (FMD) remains a major threat to global livestock health, and current inactivated vaccines face limitations in biosafety and cross-protection. Virus-like particle (VLP) -based vaccines offer a safer alternative, howev…
View article: ER Chaperone HYOU1 Couples MAM Remodeling to Autophagic Lipid Clearance in Atherosclerosis
ER Chaperone HYOU1 Couples MAM Remodeling to Autophagic Lipid Clearance in Atherosclerosis Open
Endoplasmic reticulum (ER) stress and lipid accumulation are hallmarks of atherosclerosis, but their molecular crosstalk remains poorly defined. Here, we identify the ER chaperone HYOU1 as a critical regulator of mitochondria-associated me…
View article: Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes
Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes Open
Proximity labeling with engineered ascorbate peroxidase (APEX) has been widely used to identify proteomes within various membrane-enclosed subcellular organelles. However, constructing protein distribution maps between two non-partitioned …
View article: Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia
Human Pluripotent Stem Cell‐Derived Skeletal Muscle Organoid Model of Aging‐Induced Sarcopenia Open
Background Sarcopenia is defined by the age‐related loss of muscle mass and function, with an impaired regenerative capacity of satellite cells (SCs). Despite their recognized importance in muscle regeneration, human model‐based studies on…
View article: Cryptotanshinone Targets HYOU1 to Rewire ER-Mitochondria Communication and Enhance Autophagy in Atherosclerosis
Cryptotanshinone Targets HYOU1 to Rewire ER-Mitochondria Communication and Enhance Autophagy in Atherosclerosis Open
Atherosclerosis is driven by chronic lipid accumulation, oxidative stress, and impaired autophagy, yet effective therapies targeting these pathways remain elusive. Oxidized low-density lipoprotein (oxLDL), a major contributor to atheroscle…
View article: Membrane-tethered SCOTIN condensates elicit an endoplasmic reticulum stress response by sequestering luminal BiP
Membrane-tethered SCOTIN condensates elicit an endoplasmic reticulum stress response by sequestering luminal BiP Open
The endoplasmic reticulum (ER) stress response controls the balance between cellular survival and death. Here, we implicate SCOTIN, an interferon-inducible ER protein, in activating the ER stress response and modulating cell fate through i…
View article: Harnessing Theta-Gamma Coupled Brainwave Using Ultrasound for Spinal Astrocyte Revitalization and Sustained Neuropathic Pain Relief
Harnessing Theta-Gamma Coupled Brainwave Using Ultrasound for Spinal Astrocyte Revitalization and Sustained Neuropathic Pain Relief Open
Ultrasound stimulation is a promising non-invasive method for pain treatment, but comprehending its long-lasting impact and mechanisms remains challenging. Here, we investigate the neuromodulation effects of patterned ultrasound, focusing …
View article: Mosaic display of stable hemagglutinin monomers induces broad immune responses
Mosaic display of stable hemagglutinin monomers induces broad immune responses Open
The nature of the interplay between immunity and viral variation is infinitely adaptive. Infection frequently induces immune responses against variation-prone epitopes, rather than against spatially hidden conserved epitopes. It thus remai…
View article: Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins
Super-resolution proximity labeling reveals anti-viral protein network and its structural changes against SARS-CoV-2 viral proteins Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicates in human cells by interacting with host factors following infection. To understand the virus and host interactome proximity, we introduce a super-resolution proximity …
View article: Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice
Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice Open
Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Mitochondrial uncoupling protein 1 (UCP1) is activated in BAT during cold stress and dissipates mitochondrial pro…
View article: Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease
Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease Open
Ca 2+ overload-induced mitochondrial dysfunction is considered as a major contributing factor in the pathogenesis of alcohol-associated liver disease (ALD). However, the initiating factors that drive mitochondrial Ca 2+ accumulation in ALD…
View article: Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia
Proximity Proteome Analysis Reveals Novel TREM2 Interactors in the ER-Mitochondria Interface of Human Microglia Open
Triggering receptor expressed on myeloid cells 2 (TREM2) plays a central role in microglial biology and the pathogenesis of Alzheimer’s disease (AD). Besides DNAX-activating protein 12 (DAP12), a communal adaptor for TREM2 and many other r…
View article: Vutiglabridin Alleviates Cellular Senescence Process of Dysfunctional Replication, Metabolic Regulation, and Circadian Clock in Primary Human Dermal Fibroblasts
Vutiglabridin Alleviates Cellular Senescence Process of Dysfunctional Replication, Metabolic Regulation, and Circadian Clock in Primary Human Dermal Fibroblasts Open
The process of cellular senescence, which is characterized by stable cell cycle arrest, is strongly associated with dysfunctional cellular metabolism and circadian rhythmicity, both of which are reported to result from and also be causal t…
View article: Astrocytic connection to engram neurons Increased after learning
Astrocytic connection to engram neurons Increased after learning Open
Astrocytes directly participate in learning and memory. However, the structural association between astrocytes and memory-encoding engram neurons after learning remains to be elucidated. We developed astrocyte-enhanced green fluorescent pr…
View article: Mosaic RBD nanoparticles induce intergenus cross-reactive antibodies and protect against SARS-CoV-2 challenge
Mosaic RBD nanoparticles induce intergenus cross-reactive antibodies and protect against SARS-CoV-2 challenge Open
Recurrent spillovers of α- and β-coronaviruses (CoV) such as severe acute respiratory syndrome (SARS)-CoV, Middle East respiratory syndrome-CoV, SARS-CoV-2, and possibly human CoV have caused serious morbidity and mortality worldwide. In t…
View article: Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin
Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin Open
Amphibians and fish show considerable regeneration potential via dedifferentiation of somatic cells into blastemal cells. In terms of dedifferentiation, in vitro cellular reprogramming has been proposed to share common processes with in vi…
View article: Development of new tools to study membrane-anchored mammalian Atg8 proteins
Development of new tools to study membrane-anchored mammalian Atg8 proteins Open
Mammals conserve multiple mammalian Atg8-family proteins (mATG8s) consisting of GABARAP (GABA type A receptor-associated protein) and MAP1LC3/LC3 (microtubule associated protein 1 light chain 3) subfamilies that tightly bind to autophagic …
View article: Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells
Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells Open
L-serine is a non-essential amino acid endogenously produced by astrocytes and is abundant in human diets. Beneficial roles of the metabolic products from L-serine in various conditions in the brain including neuronal development have been…
View article: Alpha-2-macroglobulin as a novel diagnostic biomarker for human bladder cancer in urinary extracellular vesicles
Alpha-2-macroglobulin as a novel diagnostic biomarker for human bladder cancer in urinary extracellular vesicles Open
Extracellular vesicles (EVs) derived from urine are promising tools for the diagnosis of urogenital cancers. Urinary EVs (uEVs) are considered potential biomarkers for bladder cancer (BC) because urine is in direct contact with the BC tumo…