Jimmy Schenk
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View article: Multinational transfusion practices and outcomes in haematology patients admitted to the intensive care unit
Multinational transfusion practices and outcomes in haematology patients admitted to the intensive care unit Open
Background and Objectives The number of critically ill patients with haematological conditions is increasing, yet transfusion practices in this population remain poorly defined. This study aimed to compare transfusion strategies in critica…
View article: Global transfusion practices in septic patients in the intensive care unit: insights from the <scp>InPUT</scp> ‐study sub‐analysis
Global transfusion practices in septic patients in the intensive care unit: insights from the <span>InPUT</span> ‐study sub‐analysis Open
Background Transfusion practices among intensive care unit (ICU) patients with sepsis vary widely. While restrictive hemoglobin thresholds for red blood cell (RBC) transfusion are well studied, the indications and thresholds for platelet a…
View article: Platelet Transfusion Practices in the ICU: A Prospective Multicenter Cohort Study
Platelet Transfusion Practices in the ICU: A Prospective Multicenter Cohort Study Open
Objective: There is a lack of comprehensive international data regarding platelet transfusion practices in the ICU. This study aimed to evaluate the current occurrence rate of platelet transfusion in the ICU and provide an overview of plat…
View article: Influence of High-Dose Heparin on CT EXTEM of ROTEM Sigma and ROTEM Delta During Cardiopulmonary Bypass
Influence of High-Dose Heparin on CT EXTEM of ROTEM Sigma and ROTEM Delta During Cardiopulmonary Bypass Open
View article: Differences in incidence of post-induction hypotension depending on the time of day: a post-hoc propensity score matched analysis
Differences in incidence of post-induction hypotension depending on the time of day: a post-hoc propensity score matched analysis Open
Post-induction hypotension was more frequent in the morning compared to the afternoon. While this finding is in line with the presumed physiological mechanisms, it may be affected by unmeasured confounding. These findings should be replica…
View article: The role of blood pressure versus oxygen administration on cerebral oxygenation during and after anaesthesia induction
The role of blood pressure versus oxygen administration on cerebral oxygenation during and after anaesthesia induction Open
BACKGROUND The effect of anaesthesia induction on cerebral perfusion is complex due to the coinciding respiratory and haemodynamic changes that occur. OBJECTIVE To examine how changes in blood pressure and oxygen administration are related…
View article: Posttransfusion recovery, quality, and metabolism of short- and long-term stored platelets during controlled inflammation
Posttransfusion recovery, quality, and metabolism of short- and long-term stored platelets during controlled inflammation Open
Platelet concentrates (PCs) are frequently used to prevent and treat bleeding in patients. However, their efficacy is reduced during inflammation as well as due to platelet storage lesion, including metabolomic shifts and changes in surfac…
View article: Treatment Modalities for Angina with Non-Obstructive Coronary Arteries (ANOCA): A Systematic Review and Meta-Analysis
Treatment Modalities for Angina with Non-Obstructive Coronary Arteries (ANOCA): A Systematic Review and Meta-Analysis Open
Background and Objectives: Up to 40% of patients undergoing a coronary angiogram due to angina pectoris have no obstructive coronary artery disease, also known as angina with non-obstructive coronary arteries (ANOCA). ANOCA is associated w…
View article: Correction to: Effects of intraoperative hyperoxia on cerebral blood flow and dynamic cerebral autoregulation
Correction to: Effects of intraoperative hyperoxia on cerebral blood flow and dynamic cerebral autoregulation Open
View article: Pre‐operative reference ranges for <scp>ROTEM</scp> <sup>®</sup> sigma in patients undergoing cardiac surgery: a secondary analysis of two prospective trial cohorts
Pre‐operative reference ranges for <span>ROTEM</span> <sup>®</sup> sigma in patients undergoing cardiac surgery: a secondary analysis of two prospective trial cohorts Open
Summary Introduction Rotational thromboelastometry (ROTEM ® ) is used widely in cardiac surgery. Reference ranges are derived from healthy volunteers but may not be interchangeable with those from patients undergoing cardiac surgery. Furth…
View article: The hypotension prediction index versus mean arterial pressure in predicting intraoperative hypotension
The hypotension prediction index versus mean arterial pressure in predicting intraoperative hypotension Open
BACKGROUND The hypotension prediction index (HPI) predicts hypotension, with randomised trials showing a significant reduction in hypotension-related metrics. However, the reliability of previous validation studies is debated, and it's unc…
View article: Interpretation of Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Importance of Clinical Context
Interpretation of Viscoelastic Hemostatic Assays in Cardiac Surgery Patients: Importance of Clinical Context Open
BACKGROUND: Rotational thromboelastometry (ROTEM) is widely used for point-of-care coagulation testing to reduce blood transfusions. Accurate interpretation of ROTEM data is crucial and requires substantial training. This study investigate…
View article: Plasma transfusion in the intensive care unit
Plasma transfusion in the intensive care unit Open
Background Current guidelines discourage prophylactic plasma use in non‐bleeding patients. This study assesses global plasma transfusion practices in the intensive care unit (ICU) and their alignment with current guidelines. Study Design a…
View article: Comparison of ROTEM® Delta and ROTEM® Sigma transfusion algorithm performance in thoracic aortic surgery: a single-centre prospective observational cohort study
Comparison of ROTEM® Delta and ROTEM® Sigma transfusion algorithm performance in thoracic aortic surgery: a single-centre prospective observational cohort study Open
View article: Effects of morning versus afternoon surgery on peri‐operative disturbance of sleep–wake timing: An observational study
Effects of morning versus afternoon surgery on peri‐operative disturbance of sleep–wake timing: An observational study Open
Introduction The circadian timing system regulates diurnal sleep–wake rhythm. Previously, we showed that, in patients undergoing elective surgery, sleep–wake timing is altered and post‐operative sleep quality is reduced. However, how the t…
View article: The influence of anesthetic drug strategy on the incidence of post-induction hypotension in elective, non-cardiac surgery – A prospective observational cohort study
The influence of anesthetic drug strategy on the incidence of post-induction hypotension in elective, non-cardiac surgery – A prospective observational cohort study Open
This study was registered in the Dutch Medical Research in Humans (OMON) register on 18 June 2019 (ID: NL7810). The study was approved by the Medical Ethics Committee of the Amsterdam UMC, location AMC, the Netherlands in December 2018 (NL…
View article: Defining Postinduction Hemodynamic Instability With an Automated Classification Model
Defining Postinduction Hemodynamic Instability With an Automated Classification Model Open
BACKGROUND: Postinduction hypotension (PIH) may be associated with increased morbidity and mortality. In earlier studies, the definition of PIH is solely based on different absolute or relative thresholds. However, the time-course (eg, how…
View article: A comparison between invasive and noninvasive measurement of the Hypotension Prediction Index
A comparison between invasive and noninvasive measurement of the Hypotension Prediction Index Open
BACKGROUND Clinical trials and validation studies demonstrate promising hypotension prediction capability by the Hypotension Prediction Index (HPI). Most studies that evaluate HPI derive it from invasive blood pressure readings, but a dire…
View article: Prediction of emergency department presentations for acute coronary syndrome using a machine learning approach
Prediction of emergency department presentations for acute coronary syndrome using a machine learning approach Open
View article: Validation and clinical applicability of the Hypotension Prediction Index in a general ICU population: a prospective observational cohort study Study acronym Prediction of Hemodynamic Instability in Patients Admitted to the ICU; the PHYSIC study
Validation and clinical applicability of the Hypotension Prediction Index in a general ICU population: a prospective observational cohort study Study acronym Prediction of Hemodynamic Instability in Patients Admitted to the ICU; the PHYSIC study Open
Background: Hypotension is associated with adverse outcomes in patients admitted to the intensive care unit (ICU). The application of an arterial blood pressure derived algorithm predicting hypotension significantly reduced hypotension dur…
View article: Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study
Detecting aortic valve stenosis based on the non-invasive blood pressure waveform—a proof of concept study Open
The incidence of aortic valve stenosis (AoS) increases with age, and once diagnosed, symptomatic severe AoS has a yearly mortality rate of 25%. AoS is diagnosed with transthoracic echocardiography (TTE), however, this gold standard is time…
View article: Performance of a Machine Learning Algorithm to Predict Hypotension in Spontaneously Breathing Non-Ventilated Post-Anesthesia and ICU Patients
Performance of a Machine Learning Algorithm to Predict Hypotension in Spontaneously Breathing Non-Ventilated Post-Anesthesia and ICU Patients Open
Background: Hypotension is common in the post-anesthesia care unit (PACU) and intensive care unit (ICU), and is associated with adverse patient outcomes. The Hypotension Prediction Index (HPI) algorithm has been shown to accurately predict…
View article: Differences in the Incidence of Hypotension and Hypertension between Sexes during Non-Cardiac Surgery: A Systematic Review and Meta-Analysis
Differences in the Incidence of Hypotension and Hypertension between Sexes during Non-Cardiac Surgery: A Systematic Review and Meta-Analysis Open
Background: Major determinants of blood pressure (BP) include sex and age. In youth, females have lower BP than males, yet in advanced age, more pronounced BP increases result in higher average BPs in females over 65. This hypothesis-gener…
View article: Hypotension during intensive care stay and mortality and morbidity: a systematic review and meta-analysis
Hypotension during intensive care stay and mortality and morbidity: a systematic review and meta-analysis Open
Exposure to hypotension during ICU stay was associated with increased mortality and AKI in the majority of included studies, and associations for both outcomes increased with increasing hypotension severity. The meta-analysis reinforced th…
View article: Surveillance of high-risk early postsurgical patients for real-time detection of complications using wireless monitoring (SHEPHERD study): results of a randomized multicenter stepped wedge cluster trial
Surveillance of high-risk early postsurgical patients for real-time detection of complications using wireless monitoring (SHEPHERD study): results of a randomized multicenter stepped wedge cluster trial Open
Background Vital signs measurements on the ward are performed intermittently. This could lead to failure to rapidly detect patients with deteriorating vital signs and worsens long-term outcome. The aim of this study was to test the hypothe…
View article: Red Blood Cell Transfusion in the Intensive Care Unit
Red Blood Cell Transfusion in the Intensive Care Unit Open
Importance Red blood cell (RBC) transfusion is common among patients admitted to the intensive care unit (ICU). Despite multiple randomized clinical trials of hemoglobin (Hb) thresholds for transfusion, little is known about how these thre…
View article: Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study
Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study Open
Background Evidence‐based recommendations for transfusion in patients with venoarterial extracorporeal membrane oxygenation (VA ECMO) are scarce. The current literature is limited to single‐center studies with small sample sizes, therefore…
View article: Validity and reliability of the Dutch translation of the OPUS’ client satisfaction with device module in chronic users of hand orthoses
Validity and reliability of the Dutch translation of the OPUS’ client satisfaction with device module in chronic users of hand orthoses Open
View article: The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study
The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study Open
View article: Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices
Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices Open
OBJECTIVES: To achieve optimal hemostatic balance in patients on extracorporeal membrane oxygenation (ECMO), a liberal transfusion practice is currently applied despite clear evidence. We aimed to give an overview of the current use of pla…