Bo Shen
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View article: Changes in the Subdoligranulum genus in patients with autoimmune disease: a systematic review and meta-analysis
Changes in the Subdoligranulum genus in patients with autoimmune disease: a systematic review and meta-analysis Open
Background Autoimmune diseases have different pathogenic mechanisms but share underlying patterns of gut microbiome perturbation and intestinal barrier dysfunction. Recent evidence suggests that an arthritogenic strain of Subdoligranulum c…
View article: Clinical association between inflammatory bowel disease and primary sclerosing cholangitis: what changes after colectomy and liver transplantation?
Clinical association between inflammatory bowel disease and primary sclerosing cholangitis: what changes after colectomy and liver transplantation? Open
Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is associated with several hepatobiliary manifestations, most importantly primary sclerosing cholangitis (PSC). The association between these entities is bidirectional…
View article: Transarterial chemoembolization for unresectable hepatocellular carcinoma: a comparative study between transradial and transfemoral approaches
Transarterial chemoembolization for unresectable hepatocellular carcinoma: a comparative study between transradial and transfemoral approaches Open
Background While transarterial chemoembolization (TACE) has been performed using both the transfemoral approach (TFA) and the transradial approach (TRA) to date, the relative superiority of these techniques remains uncertain. This study ai…
View article: Novel Use of EndoFLIP to Characterize Kock Pouch Stricture Before and After Endoscopic Intervention
Novel Use of EndoFLIP to Characterize Kock Pouch Stricture Before and After Endoscopic Intervention Open
Stricture formation is a common complication after restorative proctocolectomy and Kock pouch surgery. Endoluminal functional lumen imaging probe (EndoFLIP) is a balloon catheter device that uses impedance planimetry to provide luminal pre…
View article: Efficacy and Safety of Risankizumab in the Treatment of Crohn's Disease of the Pouch
Efficacy and Safety of Risankizumab in the Treatment of Crohn's Disease of the Pouch Open
Risankizumab has shown efficacy in the treatment of moderate-to-severe Crohn's disease (CD). The use of risankizumab in the treatment of CD of the pouch has not been previously reported. Here, we have 10 patients with biologics exposed CD …
View article: Pulmonary and renal long COVID at two-year revisit
Pulmonary and renal long COVID at two-year revisit Open
This study investigated host responses to long COVID by following up with 89 of the original 144 cohorts for 1-year (N = 73) and 2-year visits (N = 57). Pulmonary long COVID, characterized by fibrous stripes, was observed in 8.7% and 17.8%…
View article: Guiding post-pancreaticoduodenectomy interventions for pancreatic cancer patients utilizing decision tree models
Guiding post-pancreaticoduodenectomy interventions for pancreatic cancer patients utilizing decision tree models Open
Background Pancreatic ductal adenocarcinoma (PDAC) is frequently diagnosed in advanced stages, necessitating pancreaticoduodenectomy (PD) as a primary therapeutic approach. However, PD surgery can engender intricate complications. Thus, un…
View article: Stress-induced hyperglycemia is associated with the mortality of thrombotic thrombocytopenic purpura patients
Stress-induced hyperglycemia is associated with the mortality of thrombotic thrombocytopenic purpura patients Open
Background Thrombotic thrombocytopenic purpura (TTP) is a rare thrombotic microangiopathy with a rapid progression and high mortality rate. We aimed to explore early risk factors for mortality in patients with TTP. Methods We conducted a r…
View article: Insulated tip/needle-knife endoscopic stricturotomy is safe and effective for treatment of non-traversable anorectal strictures
Insulated tip/needle-knife endoscopic stricturotomy is safe and effective for treatment of non-traversable anorectal strictures Open
Background and study aims The treatment of anorectal strictures is particularly challenging and historically focused on surgical resection and/or diversion. There are a number of endoscopic options, but repeat interventions are common. The…
View article: Correction: Insulated tip/needle-knife endoscopic stricturotomy is safe and effective for treatment of non-traversable anorectal strictures
Correction: Insulated tip/needle-knife endoscopic stricturotomy is safe and effective for treatment of non-traversable anorectal strictures Open
[This corrects the article DOI: 10.1055/a-2230-7372.].
View article: Fluoroscopic Defecography Characterization of Floppy Pouch Complex with Clinical and Endoscopic Correlations
Fluoroscopic Defecography Characterization of Floppy Pouch Complex with Clinical and Endoscopic Correlations Open
Background: For patients with medically refractory ulcerative colitis, proctocolectomy with ileal pouch-anal anastomosis is often performed. This surgery generally improves the quality of life for patients but there are also many pouch-ass…
View article: Efficacy and Safety of Upadacitinib in the Treatment of Chronic Pouchitis, Cuffitis, and Crohn's Disease of the Pouch
Efficacy and Safety of Upadacitinib in the Treatment of Chronic Pouchitis, Cuffitis, and Crohn's Disease of the Pouch Open
Upadacitinib has shown efficacy in the treatment of moderate-to-severe ulcerative colitis and Crohn's disease (CD). The use of upadacitinib in the treatment of chronic antibiotics-refractory pouchitis (CARP), as well as CD of the pouch, ha…
View article: P614 Endoscopic Electroincision Therapy for Children
P614 Endoscopic Electroincision Therapy for Children Open
Background Anastomotic strictures can be successfully treated by endoscopic balloon dilation (EBD); however, the emerging modality of stricturotomy with electroincision therapy (EIT) and strictureplasty(stricturotomy followed by endoscopic…
View article: Endoscopic therapy of stoma closure site strictures in ileal pouches is safe and effective
Endoscopic therapy of stoma closure site strictures in ileal pouches is safe and effective Open
Background Strictures are a common complication after ileal pouch surgery with the most common locations being at the anastomosis, pouch inlet, and stoma closure site. No previous literature has described endoscopic therapy of stoma site s…
View article: Association between mucosectomy and endoscopic outcomes in patients with ileal pouch–anal anastomosis
Association between mucosectomy and endoscopic outcomes in patients with ileal pouch–anal anastomosis Open
Background In patients with inflammatory bowel disease (IBD) for whom medical therapy is unsuccessful or who develop colitis-associated neoplasia, restorative proctocolectomy with ileal pouch–anal anastomosis (IPAA) is often indicated. One…
View article: Management of Perianal Fistulizing Crohn’s Disease
Management of Perianal Fistulizing Crohn’s Disease Open
Perianal fistulizing Crohn’s disease (CD) represents a severe phenotype of CD that is associated with significant morbidity and reduction in quality of life. Perianal fistulizing CD is caused by a complex interplay of genetic predispositio…
View article: Visceral Adiposity Independently Predicts Time to Flare in Inflammatory Bowel Disease but Body Mass Index Does Not
Visceral Adiposity Independently Predicts Time to Flare in Inflammatory Bowel Disease but Body Mass Index Does Not Open
Background Obesity is associated with progression of inflammatory bowel disease (IBD). Visceral adiposity may be a more meaningful measure of obesity compared with traditional measures such as body mass index (BMI). This study compared vis…
View article: Vedolizumab for the Treatment of Chronic Pouchitis
Vedolizumab for the Treatment of Chronic Pouchitis Open
Treatment with vedolizumab was more effective than placebo in inducing remission in patients who had chronic pouchitis after undergoing IPAA for ulcerative colitis. (Funded by Takeda; EARNEST ClinicalTrials.gov number, NCT02790138; EudraCT…
View article: Obesity among those newly diagnosed with Crohn’s disease and ulcerative colitis compared with the general population
Obesity among those newly diagnosed with Crohn’s disease and ulcerative colitis compared with the general population Open
Objective Obesity is a potentially modifiable risk factor for inflammatory bowel disease (IBD). We aimed to evaluate the body mass index (BMI) of those diagnosed with IBD early versus late in life in the context of age-adjusted background …
View article: Kuhuang alleviates liver fibrosis by modulating gut microbiota-mediated hepatic IFN signaling and bile acid synthesis
Kuhuang alleviates liver fibrosis by modulating gut microbiota-mediated hepatic IFN signaling and bile acid synthesis Open
Background: Liver fibrosis is a common outcome of the pathological progression of chronic liver disease; however, no specific and effective therapeutic agent has been approved for its treatment. We investigated the effects of Kuhuang on li…
View article: Perioperative Management of Ulcerative Colitis: A Systematic Review
Perioperative Management of Ulcerative Colitis: A Systematic Review Open
BACKGROUND: Patients with ulcerative colitis may require colectomy for severe disease unresponsive or refractory to pharmacological therapy. Managing ulcerative colitis is complicated as there are many factors at play, including patient op…