Jin Kono
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View article: Effectiveness and Safety of a Mixture of Nobiletin and Tangeretin in Nocturia Patients: A Randomized, Placebo-Controlled, Double-Blind, Crossover Study
Effectiveness and Safety of a Mixture of Nobiletin and Tangeretin in Nocturia Patients: A Randomized, Placebo-Controlled, Double-Blind, Crossover Study Open
Nobiletin and tangeretin (NoT) are flavonoids derived from the peel of Citrus depressa, and they have been found to modulate circadian rhythms. Because nocturia can be considered a circadian rhythm disorder, we investigated the efficacy of…
View article: Analysis of trifecta outcomes in a single center with robot‐assisted partial nephrectomy for T1b renal tumors
Analysis of trifecta outcomes in a single center with robot‐assisted partial nephrectomy for T1b renal tumors Open
Introduction This study was performed to investigate the preoperative factors associated with difficulty achieving trifecta in robot‐assisted partial nephrectomy for clinical T1b renal cell carcinoma. Methods Among 187 patients who underwe…
View article: Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice
Glucocorticoids coordinate the bladder peripheral clock and diurnal micturition pattern in mice Open
Peripheral clocks function to regulate each organ and are synchronized though various molecular and behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show that glucocorticoids are a key cue for th…
View article: Bmal1 Regulates Prostate Growth via Cell-Cycle Modulation
Bmal1 Regulates Prostate Growth via Cell-Cycle Modulation Open
The circadian clock system exists in most organs and regulates diverse physiological processes, including growth. Here, we used a prostate-specific Bmal1-knockout mouse model (pBmal1 KO: PbsnCre+; Bmal1fx/fx) and immortalized human prostat…
View article: Coordination of bladder peripheral clock and diurnal micturition pattern by glucocorticoids
Coordination of bladder peripheral clock and diurnal micturition pattern by glucocorticoids Open
Peripheral clocks function to regulate each organ and are synchronized though various molecular and behavioral signals. However, signals that entrain the bladder clock remain elusive. Here, we show that glucocorticoids are a key cue for th…
View article: Primers for real-time quantitative RT-PCR.
Primers for real-time quantitative RT-PCR. Open
Primers were designed using Primer-BLAST or according to previous reports[32,66]. 32. Sengiku, A.; Ueda, M.; Kono, J.; Sano, T.; Nishikawa, N.; Kunisue, S.; Tsujihana, K.; Liou, L.S.; Kanematsu, A.; Shimba, S., et al. Circadian coordinatio…
View article: Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction Communication in Urothelial Cells
Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction Communication in Urothelial Cells Open
Bladder inflammatory diseases cause various urinary symptoms, such as urinary frequency and painful urination, that impair quality of life. In this study, we used a mouse model of cyclophosphamide (CYP)-induced bladder inflammation and imm…
View article: Primers for real-time quantitative RT-PCR.
Primers for real-time quantitative RT-PCR. Open
Primers were designed using Primer-BLAST or according to previous reports[24,62]. 24. Sengiku, A.; Ueda, M.; Kono, J.; Sano, T.; Nishikawa, N.; Kunisue, S.; Tsujihana, K.; Liou, L.S.; Kanematsu, A.; Shimba, S., et al. Circadian coordinatio…
View article: Clinical characteristics of renal transplant recipients who developed de novo donor-specific antigen in Kyoto University Hospital: a case series
Clinical characteristics of renal transplant recipients who developed de novo donor-specific antigen in Kyoto University Hospital: a case series Open
Background The clinical significance of de novo donor-specific antigen (DSA) in renal transplant recipients is not yet fully understood. This study aimed to report the prevalence of de novo DSA detected in antihuman leukocyte antigen (HLA)…
View article: Comparative analysis of perioperative outcomes between robot-assisted partial nephrectomy and open partial nephrectomy: a propensity-matched study
Comparative analysis of perioperative outcomes between robot-assisted partial nephrectomy and open partial nephrectomy: a propensity-matched study Open
Aim: Partial nephrectomy is the standard treatment for small renal tumors; however, it remains unclear which surgical approach from among robot-assisted partial nephrectomy (RAPN) and open partial nephrectomy (OPN) is superior. This study …
View article: Urothelium-Specific Deletion of Connexin43 in the Mouse Urinary Bladder Alters Distension-Induced ATP Release and Voiding Behavior
Urothelium-Specific Deletion of Connexin43 in the Mouse Urinary Bladder Alters Distension-Induced ATP Release and Voiding Behavior Open
Connexin43 (Cx43), the main gap junction and hemichannel forming protein in the urinary bladder, participates in the regulation of bladder motor and sensory functions and has been reported as an important modulator of day–night variations …
View article: Low bladder capacity is an important predictor for comorbidity of interstitial cystitis with Hunner's lesion in patients with refractory chronic prostatitis/chronic pelvic pain syndrome
Low bladder capacity is an important predictor for comorbidity of interstitial cystitis with Hunner's lesion in patients with refractory chronic prostatitis/chronic pelvic pain syndrome Open
Objective To evaluate the predictive factors for comorbidity of Hunner‐type interstitial cystitis in patients with chronic prostatitis/chronic pelvic pain syndrome using urethrocystoscopy. Methods Thirty‐two male patients were included in …
View article: [A Case of Secondary Extramammary Paget's Disease Aroundthe Cutaneous Stoma after Radical Cystectomy].
[A Case of Secondary Extramammary Paget's Disease Aroundthe Cutaneous Stoma after Radical Cystectomy]. Open
We present a case of secondary extramammary Paget's disease around the cutaneous ureterostomy stoma after radical cystectomy. An 85-year-old man with bacillus calmette-guérin refractory high-grade urothelial carcinoma underwent radical cys…
View article: PD70-11 CIRCADIAN RHYTHM COORDINATES ATP RELEASE IN THE UROTHELIUM VIA CONNEXIN43 HEMICHANNELS.
PD70-11 CIRCADIAN RHYTHM COORDINATES ATP RELEASE IN THE UROTHELIUM VIA CONNEXIN43 HEMICHANNELS. Open
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology III1 Apr 2017PD70-11 CIRCADIAN RHYTHM COORDINATES ATP RELEASE IN THE UROTHELIUM VIA CONNEXIN43 HEMICHANNE…