Jin Han
YOU?
Author Swipe
View article: Subacute Hypoxia Induces Cardiac Remodeling and Mitochondrial Dysfunction via Apoptotic Pathways in a Rabbit Model of Tracheal Stenosis
Subacute Hypoxia Induces Cardiac Remodeling and Mitochondrial Dysfunction via Apoptotic Pathways in a Rabbit Model of Tracheal Stenosis Open
Myocardial hypoxia is a major cause of cardiac dysfunction, triggering cellular injury and apoptosis. This study aims to investigate the effects of subacute hypoxia on cardiac remodeling and mitochondrial oxygen consumption. This study is …
View article: Resveratrol attenuates aging-induced mitochondrial dysfunction and mitochondria-mediated apoptosis in the rat heart
Resveratrol attenuates aging-induced mitochondrial dysfunction and mitochondria-mediated apoptosis in the rat heart Open
This study demonstrates that resveratrol treatment has a beneficial effect on aging-induced cardiac remodeling by ameliorating mitochondrial dysfunction and inhibiting mitochondria-mediated apoptosis in the heart.
View article: Therapeutic effect of novel drug candidate, PRG-N-01, on NF2 syndrome-related tumor
Therapeutic effect of novel drug candidate, PRG-N-01, on NF2 syndrome-related tumor Open
Background NF2-related schwannomatosis (NF2-SWN) is associated with multiple benign tumors in the nervous system. NF2-SWN, caused by mutations in the NF2 gene, has developed into intracranial and spinal schwannomas. Because of the high sur…
View article: Inhibition of SOD1 trimerization is a novel drug target for ALS disease
Inhibition of SOD1 trimerization is a novel drug target for ALS disease Open
Background Amyotrophic lateral sclerosis (ALS) is progressive neurodegenerative disease that begins with cell death of motor neurons in the spinal cord and leads to death from respiratory distress (breathing failure). Most of patients are …
View article: Real-Time Estimation of CO2 Absorption Capacity Using Ionic Conductivity of Protonated Di-Methyl-Ethanolamine (DMEA) and Electrical Conductivity in Low-Concentration DMEA Aqueous Solutions
Real-Time Estimation of CO2 Absorption Capacity Using Ionic Conductivity of Protonated Di-Methyl-Ethanolamine (DMEA) and Electrical Conductivity in Low-Concentration DMEA Aqueous Solutions Open
The present study investigates the real-time estimation of CO2 absorption capacity (CAC) based on the electrical conductivity (EC) of low-concentration di-methyl-ethanolamine (DMEA) solutions (0.1–0.5 M). CO2 absorption experiments are con…
View article: Immune cell dynamics and the impact on the efficiency of transvascular antitumor interventional therapies in hepatocellular carcinoma patients
Immune cell dynamics and the impact on the efficiency of transvascular antitumor interventional therapies in hepatocellular carcinoma patients Open
Objective: This study investigates the impact of transvascular antitumor interventional therapies on immune cell dynamics and its correlation with disease control and progression-free survival (PFS) in hepatocellular carcinoma (HCC) patien…
View article: Corrigendum to: Cardioprotection <i>via</i> mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart
Corrigendum to: Cardioprotection <i>via</i> mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart Open
Jehee Jang, Ki-Woon Kang, Young-Won Kim, Seohyun Jeong, Jaeyoon Park, Jihoon Park, Jisung Moon, Junghyun Jang, Seohyeon Kim, Sunghun Kim, Sungjoo Cho, Yurim Lee, Hyoung Kyu Kim, Jin Han, Eun-A Ko, Sung-Cherl Jung, Jung-Ha Kim, and Jae-Hong…
View article: Barefoot walking improves cognitive ability in adolescents
Barefoot walking improves cognitive ability in adolescents Open
Walking can have a positive impact on cognitive function in adolescents. This study aimed to compare the effects of walking with sneakers and barefoot on cognitive ability in adolescents. Fifty-nine adolescent male students were included i…
View article: Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart
Cardioprotection via mitochondrial transplantation supports fatty acid metabolism in ischemia-reperfusion injured rat heart Open
In addition to cellular damage, ischemia-reperfusion (IR) injury induces substantial damage to the mitochondria and endoplasmic reticulum. In this study, we sought to determine whether impaired mitochondrial function owing to IR could be r…
View article: Exercise alleviates cisplatin-induced toxicity in the hippocampus of mice by inhibiting neuroinflammation and improving synaptic plasticity
Exercise alleviates cisplatin-induced toxicity in the hippocampus of mice by inhibiting neuroinflammation and improving synaptic plasticity Open
Chemotherapy-induced cognitive impairment is recognized as the most typical symptom in patients with cancer that occurs during and following the chemotherapy treatment. Recently many studies focused on pharmaceutical strategies to control …
View article: How to Measure Mitochondrial Oxygen Respiration
How to Measure Mitochondrial Oxygen Respiration Open
PURPOSE: With the widespread of mitochondrial function, the need to accurately quantify and comprehend mitochondrial O2 respiration has gained prominence within the physiological and pathological spheres. Various in situ, in vitro, and in …
View article: Neopetroside-B alleviates doxorubicin-induced cardiotoxicity via mitochondrial protection
Neopetroside-B alleviates doxorubicin-induced cardiotoxicity via mitochondrial protection Open
Doxorubicin, a member of the anthracycline family, is a widely prescribed anticancer chemotherapy drug. Unfortunately, cumulative doses of doxorubicin can cause mitochondrial dysfunction, leading to acute or chronic cardiotoxicity. This st…
View article: Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice
Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice Open
Echinochrome A (EchA) is a natural bioproduct extracted from sea urchins, and is an active component of the clinical drug, Histochrome®. EchA has antioxidant, anti-inflammatory, and antimicrobial effects. However, its effects on diabetic n…
View article: Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice
Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice Open
Abnormal sulfide catabolism, especially the accumulation of hydrogen sulfide (H2S) during hypoxic or inflammatory stresses, is a major cause of redox imbalance-associated cardiac dysfunction. Polyhydroxynaphtoquinone echinochrome A (Ech-A)…
View article: Regulation of Inflammation-Mediated Endothelial to Mesenchymal Transition with Echinochrome a for Improving Myocardial Dysfunction
Regulation of Inflammation-Mediated Endothelial to Mesenchymal Transition with Echinochrome a for Improving Myocardial Dysfunction Open
Endothelial–mesenchymal transition (EndMT) is a process by which endothelial cells (ECs) transition into mesenchymal cells (e.g., myofibroblasts and smooth muscle cells) and induce fibrosis of cells/tissues, due to ischemic conditions in t…
View article: Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats
Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats Open
Post-menopausal dry mouth or xerostomia is caused by reduced salivary secretion. This study aimed to investigate the efficacy of echinochrome A (Ech A) in alleviating submandibular gland dysfunctions in ovariectomized rats that mimic menop…
View article: Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium
Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium Open
The diverse therapeutic feasibility of the sea urchin-derived naphthoquinone pigment, Echinochrome A (Ech A), has been studied. Simple and noninvasive administration routes should be explored, to obtain the feasibility. Although the therap…
View article: Mitochondrial energy metabolic transcriptome profiles during cardiac differentiation from mouse and human pluripotent stem cells
Mitochondrial energy metabolic transcriptome profiles during cardiac differentiation from mouse and human pluripotent stem cells Open
Simultaneous myofibril and mitochondrial development is crucial for the cardiac differentiation of pluripotent stem cells (PSCs). Specifically, mitochondrial energy metabolism (MEM) development in cardiomyocytes is essential for the beatin…
View article: Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling
Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling Open
Excessive increase in melanin pigment in the skin can be caused by a variety of environmental factors, including UV radiation, and can result in spots, freckles, and skin cancer. Therefore, it is important to develop functional whitening c…
View article: Regulation of inflammation-mediated endothelial to mesenchymal transition with Echinochrome A for improving myocardial dysfunction
Regulation of inflammation-mediated endothelial to mesenchymal transition with Echinochrome A for improving myocardial dysfunction Open
Cardiovascular disease induced by myocardial ischemia is caused by excessive oxidative stress, which eventually leads to cell death and tissue damage. Endothelial–mesenchymal transition (EndMT) is a process by which endothelial cells (ECs)…
View article: Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction
Tomatidine-stimulated maturation of human embryonic stem cell-derived cardiomyocytes for modeling mitochondrial dysfunction Open
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) have been reported to exhibit immature embryonic or fetal cardiomyocyte-like phenotypes. To enhance the maturation of hESC-CMs, we identified a natural steroidal alkaloid, tomatid…
View article: Gallic acid-mitochondria targeting sequence-H<sub>3</sub>R<sub>9</sub> induces mitochondria-targeted cytoprotection
Gallic acid-mitochondria targeting sequence-H<sub>3</sub>R<sub>9</sub> induces mitochondria-targeted cytoprotection Open
The development of selective targeting of drug molecules towards the mitochondria is an important issue related to therapy efficacy. In this study, we report that gallic acid (GA)-mitochondria targeting sequence (MTS)-H3R9 exhibits a dual …
View article: Synergism of a novel MCL‑1 downregulator, acriflavine, with navitoclax (ABT‑263) in triple‑negative breast cancer, lung adenocarcinoma and glioblastoma multiforme
Synergism of a novel MCL‑1 downregulator, acriflavine, with navitoclax (ABT‑263) in triple‑negative breast cancer, lung adenocarcinoma and glioblastoma multiforme Open
Myeloid cell leukemia sequence 1 (MCL-1), an anti-apoptotic B-cell lymphoma 2 (BCL-2) family molecule frequently amplified in various human cancer cells, is known to be critical for cancer cell survival. MCL-1 has been recognized as a targ…
View article: Effects of cisplatin on mitochondrial function and autophagy-related proteins in skeletal muscle of rats
Effects of cisplatin on mitochondrial function and autophagy-related proteins in skeletal muscle of rats Open
Cisplatin is widely known as an anti-cancer drug. However, the effects of cisplatin on mitochondrial function and autophagyrelated proteins levels in the skeletal muscle are unclear. The purpose of this study was to investigate the effect …