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View article: Droplet Squeeze Microfluidic Platform for Generating Extracellular Vesicle Hybrids for Drug Delivery
Droplet Squeeze Microfluidic Platform for Generating Extracellular Vesicle Hybrids for Drug Delivery Open
Extracellular vesicles (EVs) are emerging as versatile drug delivery systems due to their intrinsic biocompatibility and targeting capabilities. However, EV integrity and efficient drug loading challenges hinder their clinical translation.…
View article: Enhancing Chimeric Antigen Receptor T‐Cell Generation via Microfluidic Mechanoporation and Lipid Nanoparticles
Enhancing Chimeric Antigen Receptor T‐Cell Generation via Microfluidic Mechanoporation and Lipid Nanoparticles Open
Chimeric antigen receptor (CAR)‐T cell therapy has revolutionized cancer treatment by engineering patients' T cells to specifically target cancer cells. Traditional CAR‐T cell manufacturing methods use viral transduction to integrate CAR g…
View article: Squeezable Hydrogel Microparticles for Single Extracellular Vesicle Protein Profiling
Squeezable Hydrogel Microparticles for Single Extracellular Vesicle Protein Profiling Open
Extracellular vesicles (EVs) are promising for molecular diagnostics, but current analyses are limited by the rarity and compositional heterogeneity of EV protein expression. Therefore, single EV profiling methods require high sensitivity,…
View article: Optimizing cell therapy by sorting cells with high extracellular vesicle secretion
Optimizing cell therapy by sorting cells with high extracellular vesicle secretion Open
Critical challenges remain in clinical translation of extracellular vesicle (EV)-based therapeutics due to the absence of methods to enrich cells with high EV secretion. Current cell sorting methods are limited to surface markers that are …
View article: A Versatile Microchannel Array Device for Portable and Parallel Droplet Generation
A Versatile Microchannel Array Device for Portable and Parallel Droplet Generation Open
The efficient generation of monodispersed droplets holds great promise for micro‐/nanoparticle synthesis and biochemical analysis. However, it remains a challenge to achieve high‐throughput generation of monodispersed droplets in a portabl…
Live Organoid Cyclic Imaging Open
Organoids are becoming increasingly relevant in biology and medicine for their physiological complexity and accuracy in modeling human disease. To fully assess their biological profile while preserving their spatial information, spatiotemp…
View article: Anti‐cancer bioactivity of sweet basil leaf derived extracellular vesicles on pancreatic cancer cells
Anti‐cancer bioactivity of sweet basil leaf derived extracellular vesicles on pancreatic cancer cells Open
Most living organisms secrete tiny lipid bilayer particles encapsulating various biomolecular entities, including nucleic acids and proteins. These secreted extracellular vesicles (EVs) are shown to aid in communication between cells and t…
Specific interaction between the DSPHTELP peptide and various functional groups Open
The specific interaction of an 8-mer peptide from the coat protein (pVIII) of the DSPH M13 bacteriophage was investigated.
View article: Double Digital Assay for Single Extracellular Vesicle and Single Molecule Detection
Double Digital Assay for Single Extracellular Vesicle and Single Molecule Detection Open
Extracellular vesicles (EVs) have emerged as a promising source of biomarkers for disease diagnosis. However, current diagnostic methods for EVs present formidable challenges, given the low expression levels of biomarkers carried by EV sam…
Optimizing Cell Therapy by Sorting Cells with High Extracellular Vesicle Secretion Open
Critical challenges remain in clinical translation of extracellular vesicle (EV)-based therapeutics due to the absence of methods to enrich cells with high EV secretion. Current cell sorting methods are limited to surface markers that are …
View article: Equine mesenchymal stem cell derived extracellular vesicle immunopathology biomarker discovery
Equine mesenchymal stem cell derived extracellular vesicle immunopathology biomarker discovery Open
The use of mesenchymal stem cells (MSCs) in human and veterinary clinical applications has become a subject of increasing importance due to their roles in immunomodulation and regenerative processes. MSCs are especially relevant in equine …
View article: Table S3 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer
Table S3 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Open
Workflow and the corresponding result.
View article: Figure S4 from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma
Figure S4 from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma Open
Figure S4. Individual biomarker profiles within the training set. 14 biomarkers' levels by patient group within the training set of 47 subjects. Pancreatic cancer patients (PDAC) relative to Non-Cancer patients (NC). Mann-Whitney test was …
Table S1 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Open
miRNA biomarker selection from EV miRNA Sequencing.
View article: Figure S3 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer
Figure S3 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Open
Diagnostic performance of individual miRNAs.
View article: Figure S2 from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma
Figure S2 from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma Open
Figure S2. miRNA sequencing to discover miRNA biomarkers to discern PDAC from non-cancer. (A) Raw miRNA sequencing data from 6 healthy controls, 6 non-cancer disease controls, 5 M0 PDAC patients, and 12 M1 PDAC patients. (B) 8 potential mi…
View article: Data from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma
Data from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma Open
Purpose:To determine whether a multianalyte liquid biopsy can improve the detection and staging of pancreatic ductal adenocarcinoma (PDAC).Experimental Design:We analyzed plasma from 204 subjects (71 healthy, 44 non-PDAC pancreatic disease…
View article: Table S1 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer
Table S1 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Open
miRNA biomarker selection from EV miRNA Sequencing.
Data from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Open
Improved diagnostics for pancreatic ductal adenocarcinoma (PDAC) to detect the disease at earlier, curative stages and to guide treatments is crucial to progress against this disease. The development of a liquid biopsy for PDAC has proven …
Data from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Open
Improved diagnostics for pancreatic ductal adenocarcinoma (PDAC) to detect the disease at earlier, curative stages and to guide treatments is crucial to progress against this disease. The development of a liquid biopsy for PDAC has proven …
Figure S3 from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma Open
Figure S3. Multi-analyte panel generation procedure of PDAC/NC diagnosis and occult metastases detection
Figure S1 from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma Open
Figure S1. Sample cohort of this study, which included 204 subjects in total. Workflow shows patient cohorts involved in each classification. * indicated 8 patients repeated in the discovery set and the training set. ** indicated 32 locall…
Figure S2 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Open
Significantly enriched pathways from the 11 identified miRNA markers.
Figure S1 from miRNA Profiling of Magnetic Nanopore–Isolated Extracellular Vesicles for the Diagnosis of Pancreatic Cancer Open
Significantly differentially expressed miRNAs.
Data from A Multianalyte Panel Consisting of Extracellular Vesicle miRNAs and mRNAs, cfDNA, and CA19-9 Shows Utility for Diagnosis and Staging of Pancreatic Ductal Adenocarcinoma Open
Purpose:To determine whether a multianalyte liquid biopsy can improve the detection and staging of pancreatic ductal adenocarcinoma (PDAC).Experimental Design:We analyzed plasma from 204 subjects (71 healthy, 44 non-PDAC pancreatic disease…