Jinbo Cheng
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View article: Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice
Microglial Prrc2a regulates microglia-neuron interaction in cerebellum and motor functions in mice Open
Summary: The crosstalk between microglia and neuron has been recognized as a crucial process in the development and disorders of the central nervous system. The present study probes into the role of Prrc2a—a post-transcriptional regulator …
View article: ACLY regulates autolysosome acidification through tubulin acetylation‐mediated assembly of V‐ATPase subunits in Alzheimer's disease model mice
ACLY regulates autolysosome acidification through tubulin acetylation‐mediated assembly of V‐ATPase subunits in Alzheimer's disease model mice Open
INTRODUCTION Faulty autolysosome acidification leads to dystrophic neurites—an early event propelling Alzheimer's disease (AD) progression—yet the underlying mechanism remains elusive. METHODS To elucidate the physiological functions of ne…
View article: Microglial <i>Rack1</i> Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis
Microglial <i>Rack1</i> Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis Open
Alzheimer's disease (AD) is the most common neurodegenerative disorder. Microglia make significant contributions to neuroinflammation and the progression of AD. However, the regulatory role of microglial activation and the communication be…
View article: Protective effects of 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside against cadmium toxicity involve BDNF/TrkB and PI3K/Akt signaling pathways
Protective effects of 2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside against cadmium toxicity involve BDNF/TrkB and PI3K/Akt signaling pathways Open
Polygonum multiflorum is a traditional Chinese medicinal herb used to nourish the blood, promote hair growth, and support neurological health. Its key bioactive component, 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG), has shown p…
View article: Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases
Neuromodulatory role and therapeutic potential of N6-methyladenosine RNA methylation in neurodegenerative diseases Open
N 6 -methyladenosine RNA methylation, an essential post-transcriptional modification, dynamically regulates RNA metabolism and plays a crucial role in neuronal function. Growing evidence suggests that dysregulated N 6 -methyladenosine modi…
View article: The changes of NLRs family members in the brain of AD mouse model and AD patients
The changes of NLRs family members in the brain of AD mouse model and AD patients Open
Introduction Alzheimer’s disease (AD), a prevalent neurodegenerative disease, is primarily characterized by progressive neuron loss and memory impairment. NOD-like receptors (NLRs) are crucial for immune regulation and maintaining cellular…
View article: Preparation and Properties of Basalt Fiber‐Reinforced Aqueous Polybenzoxazine Composite Aerogels Based on One‐Step Freeze‐Drying Method
Preparation and Properties of Basalt Fiber‐Reinforced Aqueous Polybenzoxazine Composite Aerogels Based on One‐Step Freeze‐Drying Method Open
Polybenzoxazine (PBa) aerogels have gained much attention as a fire‐retardant material because of their flexible molecular design and excellent mechanical properties. Incorporation of inorganic fibers into PBa aerogels using a simple and e…
View article: Efficient Nanofibrous Electromagnetic Wave Absorber Inspired by Spider Silk Hunting
Efficient Nanofibrous Electromagnetic Wave Absorber Inspired by Spider Silk Hunting Open
With the rapid advancements in wireless communication and radar detection technologies, there has been a significant uptick in the utilization frequency of electromagnetic waves across both civilian and military sectors, consequently gener…
View article: Roles of microglial calcium channels in neurodegenerative diseases
Roles of microglial calcium channels in neurodegenerative diseases Open
Microglia are crucial for neurodevelopment, and the maintenance of central nervous system functions. Calcium signals in microglia regulate the neuronal plasticity critical for learning, memory, and neuron survival. Growing evidence highlig…
View article: PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA
PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA Open
Oligodendrocyte progenitor cells (OPCs) differentiate into myelin-producing cells and modulate neuronal activity. Defects in OPC development are associated with neurological diseases. N6-methyladenosine (m6A) contributes to neural developm…
View article: Commentary: Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders
Commentary: Targeting chemoattractant chemokine (C–C motif) ligand 2 derived from astrocytes is a promising therapeutic approach in the treatment of neuromyelitis optica spectrum disorders Open
GENERAL COMMENTARY article Front. Immunol., 27 September 2023Sec. Inflammation Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1279782
View article: Editorial: Noncoding RNA-based spatiotemporal modulation and therapeutics in neuroinflammation
Editorial: Noncoding RNA-based spatiotemporal modulation and therapeutics in neuroinflammation Open
Neuroinflammation is a multifactorial process occurring in the central nervous system (CNS) that is intimately linked to temporal and spatial regulation of gene expression mediated by noncoding RNAs (ncRNAs). ncRNAs are present at high con…
View article: Role and regulatory mechanism of microRNA mediated neuroinflammation in neuronal system diseases
Role and regulatory mechanism of microRNA mediated neuroinflammation in neuronal system diseases Open
MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific RNAs and regulate many cellular processes. Neuroinflammation plays the pivotal role in the occurrence and development of multiple central ner…
View article: ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease Open
Background Nuclear acetyl-CoA pools govern histone acetylation that controls synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer’s disease (AD). Nuclear acetyl-CoA pools are generated partially from lo…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice
The Role of PRRC2B in Cerebral Vascular Remodeling Under Acute Hypoxia in Mice Open
High altitude exposure leads to various cognitive impairments. The cerebral vasculature system plays an integral role in hypoxia‐induced cognitive defects by reducing oxygen and nutrition supply to the brain. RNA N6‐methyladenosine (m6A) i…
View article: Dlg1 deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior
Dlg1 deletion in microglia ameliorates chronic restraint stress induced mice depression-like behavior Open
Background: Major depression is one of the most common psychiatric disorders worldwide, inflicting suffering, significant reduction in life span, and financial burdens on families and society. Mounting evidence implicates that exposure to …
View article: Phosphorus-Containing Polybenzoxazine Aerogels with Efficient Flame Retardation and Thermal Insulation
Phosphorus-Containing Polybenzoxazine Aerogels with Efficient Flame Retardation and Thermal Insulation Open
Bisphenol A type benzoxazine (Ba) monomers and 10-(2, 5-dihydroxyphenyl)-10- hydrogen-9- oxygen-10- phosphine-10- oxide (DOPO-HQ) were employed to prepare flame retardant and heat insulated polybenzoxazine (PBa) composite aerogels. The suc…
View article: Issue Information
Issue Information Open
No abstract is available for this article.
View article: Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia
Deletion of Calhm2 alleviates MPTP-induced Parkinson's disease pathology by inhibiting EFHD2-STAT3 signaling in microglia Open
Background: Neuroinflammation is involved in the development of Parkinson's disease (PD). Calhm2 plays an important role in the development of microglial inflammation, but whether Calhm2 is involved in PD and its regulatory mechanisms are …
View article: The role and regulatory mechanism of m6A methylation in the nervous system
The role and regulatory mechanism of m6A methylation in the nervous system Open
N6-methyladenosine (m 6 A) modification regulates RNA translation, splicing, transport, localization, and stability at the post-transcriptional level. The m 6 A modification has been reported to have a wide range of effects on the nervous …
View article: Editorial: The role of astrocyte in vascular aging
Editorial: The role of astrocyte in vascular aging Open
EDITORIAL article Front. Aging Neurosci., 03 August 2022Sec. Cellular and Molecular Mechanisms of Brain-aging https://doi.org/10.3389/fnagi.2022.961288
View article: Mangiferin Alleviates Postpartum Depression–Like Behaviors by Inhibiting MAPK Signaling in Microglia
Mangiferin Alleviates Postpartum Depression–Like Behaviors by Inhibiting MAPK Signaling in Microglia Open
Postpartum depression (PPD), a severe mental health disorder, is closely associated with decreased gonadal hormone levels during the postpartum period. Mangiferin (MGF) possesses a wide range of pharmacological activities, including anti-i…
View article: The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson’s Disease by Inhibiting the NF-κB/NLRP3 Pathway
The XPO1 Inhibitor KPT-8602 Ameliorates Parkinson’s Disease by Inhibiting the NF-κB/NLRP3 Pathway Open
Exportin 1 (XPO1) is an important transport receptor that mediates the nuclear export of various proteins and RNA. KPT-8602 is a second-generation inhibitor of XPO1, demonstrating the lowest level of side effects, and is currently in clini…
View article: Beneficial Effects of 1500 MHz Microwave on Old 5×FAD Mice
Beneficial Effects of 1500 MHz Microwave on Old 5×FAD Mice Open
Background: Treatment of Alzheimer’s disease is still a medical challenge now. Some researchers have tried to use electromagnetic therapy to treat Alzheimer’s disease, but there are no clear conclusions. 1500 MHz microwave was used to expo…
View article: Large Screening Identifies ACE2 Positively Correlates With NF-κB Signaling Activity and Targeting NF-κB Signaling Drugs Suppress ACE2 Levels
Large Screening Identifies ACE2 Positively Correlates With NF-κB Signaling Activity and Targeting NF-κB Signaling Drugs Suppress ACE2 Levels Open
Coronaviruses SARS-CoV-2 infected more than 156 million people and caused over 3 million death in the whole world, therefore a better understanding of the underlying pathogenic mechanism and the searching for more effective treatments were…
View article: Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology
Microglial Calhm2 regulates neuroinflammation and contributes to Alzheimer’s disease pathology Open
Calhm2 has an important role in microglial activation and contributes to Alzheimer’s disease pathology.