Jinchu Vijay
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View article: 38 OLIG2 MEDIATES A RARE TARGETABLE STEM CELL FATE TRANSITION IN SONIC HEDGEHOG MEDULLOBLASTOMA
38 OLIG2 MEDIATES A RARE TARGETABLE STEM CELL FATE TRANSITION IN SONIC HEDGEHOG MEDULLOBLASTOMA Open
Functional cellular heterogeneity in tumours often underlies incomplete response to therapy and relapse. Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted in …
View article: OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma
OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma Open
Functional cellular heterogeneity in tumours often underlies incomplete response to therapy and relapse. Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted in …
View article: CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis
CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis Open
Ferroptosis is an iron-dependent cell death mechanism characterized by the accumulation of toxic lipid peroxides and cell membrane rupture. GPX4 (glutathione peroxidase 4) prevents ferroptosis by reducing these lipid peroxides into lipid a…
View article: AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants
AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants Open
View article: OR33-05 Amino Acid Signature of Abdominal Obesity in the TwinsUK Cohort
OR33-05 Amino Acid Signature of Abdominal Obesity in the TwinsUK Cohort Open
Background and aim: Metabolomic studies have shown that circulating amino acid levels are altered in the context of obesity. The branched-chain amino acids (BCAAs, namely leucine, isoleucine and valine) have been the most studied because o…
View article: Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types
Single-cell analysis of human adipose tissue identifies depot- and disease-specific cell types Open
View article: UCP1 expression–associated gene signatures of human epicardial adipose tissue
UCP1 expression–associated gene signatures of human epicardial adipose tissue Open
Multiple reports of uncoupling protein 1 (UCP1) expression have established its presence in human epicardial adipose tissue (eAT). Its functional relevance to eAT, however, remains largely unknown. In a recent study, we reported that adren…
View article: Author Correction: An atlas of genetic influences on osteoporosis in humans and mice
Author Correction: An atlas of genetic influences on osteoporosis in humans and mice Open
View article: Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements
Dissecting features of epigenetic variants underlying cardiometabolic risk using full-resolution epigenome profiling in regulatory elements Open
View article: An atlas of genetic influences on osteoporosis in humans and mice
An atlas of genetic influences on osteoporosis in humans and mice Open
View article: An Atlas of Human and Murine Genetic Influences on Osteoporosis
An Atlas of Human and Murine Genetic Influences on Osteoporosis Open
Osteoporosis is a common debilitating chronic disease diagnosed primarily using bone mineral density (BMD). We undertook a comprehensive assessment of human genetic determinants of bone density in 426,824 individuals, identifying a total o…