Jincui Gu
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View article: Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and interferon signaling in lung cancers harboring KEAP1/STK11 mutations
Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and interferon signaling in lung cancers harboring KEAP1/STK11 mutations Open
Background KEAP1 and STK11 are frequently mutated in NSCLC, and are associated with compromised response to immunotherapy, the underlying mechanism of which is not fully understood. Methods To assess the impact of KEAP1 / STK11 mutations o…
View article: Advances in Hygroscopic Polymer Gels toward Efficient Atmospheric Moisture Capture and Management
Advances in Hygroscopic Polymer Gels toward Efficient Atmospheric Moisture Capture and Management Open
Atmospheric humidity, as a widely distributed environmental resource, holds great potential to create significant value for human society via efficient regulation and utilization. Hygroscopic polymer gels (HPGs) have emerged as a highly pr…
View article: Case Report: Treatment response of SQSTM1–ALK fusion lung adenocarcinoma to multiple ALK inhibitors
Case Report: Treatment response of SQSTM1–ALK fusion lung adenocarcinoma to multiple ALK inhibitors Open
Objectives The echinoderm microtubule-associated protein-like 4 ( EML4 ) gene and anaplastic lymphoma kinase (ALK) gene fusion is the most common ALK rearrangement in non-small-cell lung cancer (NSCLC). SQSTM1 (exon 5)–ALK (exon 20) fusion…
View article: Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and Interferon signaling in lung cancers harboring KEAP1/STK11 mutations
Redox phenotype confers T cell-exclusion microenvironment and resistance to immunotherapy by suppressing STING/MDA5 expression and Interferon signaling in lung cancers harboring KEAP1/STK11 mutations Open
Background KEAP1 and STK11 are frequently mutated in NSCLC, and are associated with compromised response to immunotherapy, the underlying mechanism of which is not fully understood. Methods To assess the impact of KEAP1/STK11 mutations on …
View article: The effectiveness of nirmatrelvir/ritonavir regimen in hospitalized renal transplant patients with prolonged COVID-19 infection: a multicenter clinical experience
The effectiveness of nirmatrelvir/ritonavir regimen in hospitalized renal transplant patients with prolonged COVID-19 infection: a multicenter clinical experience Open
A regimen including NR for clearing SARS-CoV-2 along with reducing immunosuppressants and using intravenous corticosteroids is associated with lower rates of exacerbation and mortality in KTRs who have moderate to critical SARS-CoV-2 infec…
View article: The prognostic analysis and a machine-learning based disease-specific survival state model in pulmonary large-cell neuroendocrine carcinomas
The prognostic analysis and a machine-learning based disease-specific survival state model in pulmonary large-cell neuroendocrine carcinomas Open
Male, age ≥65 years, distant metastasis to the bone, liver, and brain are associated with a worse prognosis in PLCNEC patients, while surgery and chemotherapy are associated with improved prognosis. GBDT showed promising performance in pre…
View article: <scp>FHL2</scp> promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the <scp>PI3K</scp>/<scp>AKT</scp>/<scp>mTOR</scp> pathway
<span>FHL2</span> promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the <span>PI3K</span>/<span>AKT</span>/<span>mTOR</span> pathway Open
Background Increasing evidence indicates that four and a half LIM domains 2 (FHL2) plays a crucial role in the progression of various cancers. However, the biological functions and molecular mechanism of FHL2 in lung adenocarcinoma (LUAD) …
View article: Construction of an Immunogenic Cell Death-Related LncRNA Signature to Predict the Prognosis of Patients with Lung Adenocarcinoma
Construction of an Immunogenic Cell Death-Related LncRNA Signature to Predict the Prognosis of Patients with Lung Adenocarcinoma Open
Background LUAD is one of the most common malignancies worldwide. This study aimed to construct an immunogenic cell death (ICD)-related long non-coding RNA (lncRNA) signature to effectively predict the prognosis of LUAD patients. Methods T…
View article: Supramolecular fabrication of hyperbranched polyethyleneimine toward nanofiltration membrane for efficient wastewater purification
Supramolecular fabrication of hyperbranched polyethyleneimine toward nanofiltration membrane for efficient wastewater purification Open
Nanofiltration technology has opened an efficient pathway to addressing the grand issue of wastewater purification. Polyethyleneimine (PEI), as a hydrophilic polymer, is a promising material to manufacture separation membranes owing to its…
View article: PTEN Loss Correlates with T cell Exclusion across Human Cancers
PTEN Loss Correlates with T cell Exclusion across Human Cancers Open
Background: Recent evidences had shown that loss in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was associated with immunotherapy resistance, which may be attributed to the non-T-cell-inflamed tumor microenvironment. The…
View article: PTEN loss correlates with T cell exclusion across human cancers
PTEN loss correlates with T cell exclusion across human cancers Open
Background Recent evidences had shown that loss in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) was associated with immunotherapy resistance, which may be attributed to the non-T-cell-inflamed tumor microenvironment. The …
View article: Water Purification: Sphagnum Inspired g‐C<sub>3</sub>N<sub>4</sub> Nano/Microspheres with Smaller Bandgap in Heterojunction Membranes for Sunlight‐Driven Water Purification (Small 12/2021)
Water Purification: Sphagnum Inspired g‐C<sub>3</sub>N<sub>4</sub> Nano/Microspheres with Smaller Bandgap in Heterojunction Membranes for Sunlight‐Driven Water Purification (Small 12/2021) Open
In article number 2007122, Min Chao, Jincui Gu, Xun Wang, Tao Chen, and co-workers present an advanced all-in-one separation membrane, which can realize continuous water purification with stable separation performance, catalytic degradatio…
View article: Additional file 2 of PTEN loss correlates with T cell exclusion across human cancers
Additional file 2 of PTEN loss correlates with T cell exclusion across human cancers Open
Additional file 2: Supplementary Figure 1. Association of PTEN genomic alteration with PTEN expression and key pathway activation. Difference of PTEN mRNA expression, PI3K-AKT-mTOR pathway activation(represented by p-AKT [phosphorylated at…
View article: Additional file 1 of PTEN loss correlates with T cell exclusion across human cancers
Additional file 1 of PTEN loss correlates with T cell exclusion across human cancers Open
Additional file 1: Supplementary Table 1. Summary of the basic information of 21 solid tumors. Supplementary Table 2. Detailed information of Chen et al. cohort. Supplementary Table 3. Detailed information of Riaz et al. cohort
View article: Retrospective study on the efficacy of bisphosphonates in tyrosine kinase inhibitor‑treated patients with non‑small cell lung cancer exhibiting bone metastasis
Retrospective study on the efficacy of bisphosphonates in tyrosine kinase inhibitor‑treated patients with non‑small cell lung cancer exhibiting bone metastasis Open
Bisphosphonates (Bps) inhibit the maturation of osteoclasts and suppress the adhesion of cancer cells to the bone matrix. They are recommended as the standard treatment for tumors exhibiting bone metastasis (BM). However, whether Bps can i…
View article: Recent advance of two-dimensional carbon-based films and their polymer functionalized membranes for oil/water separation
Recent advance of two-dimensional carbon-based films and their polymer functionalized membranes for oil/water separation Open
Oily water treatment has become an urgent task in our daily life because of the environmental and economic demands. Traditionally, gravity separation, flotation and filtration are used to separate oil/water mixtures successfully, but these…
View article: Deciphering Microenvironment of NSCLC based on CD8+ TIL Density and PD-1/PD-L1 Expression
Deciphering Microenvironment of NSCLC based on CD8+ TIL Density and PD-1/PD-L1 Expression Open
Purpose: To determine whether distinct tissue immune microenvironments differentially impact on clinical outcome in non-small cell lung cancer (NSCLC), an extended analysis of PD-1/PD-L1 and Tumor Infiltrating Lymphocytes (TILs) was perfor…
View article: Development of an Enzyme-Linked Immunosorbent Assay and Gold-Labelled Immunochromatographic Strip Assay for the Detection of Ancient Wool
Development of an Enzyme-Linked Immunosorbent Assay and Gold-Labelled Immunochromatographic Strip Assay for the Detection of Ancient Wool Open
The identification of ancient wool is of great importance in archaeology. Despite lots of meaningful information can be achieved by conventional detection methods, that is, light and electron microscopy, spectroscopy, and chromatography, t…
View article: Value of combining serum carcinoembryonic antigen and PET/CT in predicting EGFR mutation in non-small cell lung cancer
Value of combining serum carcinoembryonic antigen and PET/CT in predicting EGFR mutation in non-small cell lung cancer Open
Gender, histology, pretreatment serum CEA level and SUVmax are significant predictors for EGFR mutations in NSCLC. Combining these factors in predicting EGFR mutations has a moderate diagnostic accuracy, and is helpful in guiding anti-tumo…