Jine Yang
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View article: Stress-Related LncRNAs and Their Roles in Diabetes and Diabetic Complications
Stress-Related LncRNAs and Their Roles in Diabetes and Diabetic Complications Open
Diabetes mellitus (DM) is a chronic metabolic disorder and one of the most significant global health burdens worldwide. Key pathophysiological mechanisms underlying its onset and associated complications include hyperglycemia-related stres…
View article: Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases Open
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether pyroptosis can be a death form of MC remains unknown. Proteasome-mediated protein degradation…
View article: <scp>LINC00998</scp>‐encoded micropeptide <scp>SMIM30</scp> promotes the <scp>G1</scp>/S transition of cell cycle by regulating cytosolic calcium level
<span>LINC00998</span>‐encoded micropeptide <span>SMIM30</span> promotes the <span>G1</span>/S transition of cell cycle by regulating cytosolic calcium level Open
The biological functions of short open reading frame (sORF)‐encoded micropeptides remain largely unknown. Here, we report that LINC00998 , a previously annotated lncRNA, was upregulated in multiple cancer types and the sORF on LINC00998 en…
View article: A p53/lnc‐Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance
A p53/lnc‐Ip53 Negative Feedback Loop Regulates Tumor Growth and Chemoresistance Open
Acetylation is a critical mechanism to modulate tumor‐suppressive activity of p53, but the causative roles of long non‐coding RNAs (lncRNAs) in p53 acetylation and their biological significance remain unexplored. Here, lncRNA LOC100294145 …
View article: LncRNA GOLGA2P10 is induced by PERK/ATF4/CHOP signaling and protects tumor cells from ER stress-induced apoptosis by regulating Bcl-2 family members
LncRNA GOLGA2P10 is induced by PERK/ATF4/CHOP signaling and protects tumor cells from ER stress-induced apoptosis by regulating Bcl-2 family members Open
Elevated endoplasmic reticulum (ER) stress is frequently observed in cancers, whereas sustained ER stress may trigger apoptosis. How cancer cells escape from ER stress-induced apoptosis remain unclear. Here, we found that a pseudogene-deri…
View article: Lnc‐UCID Promotes G1/S Transition and Hepatoma Growth by Preventing DHX9‐Mediated CDK6 Down‐regulation
Lnc‐UCID Promotes G1/S Transition and Hepatoma Growth by Preventing DHX9‐Mediated CDK6 Down‐regulation Open
Although thousands of long noncoding RNAs (lncRNAs) have been annotated, only a limited number of them have been functionally characterized. Here, we identified an oncogenic lncRNA, named lnc‐UCID ( lnc RNA u p‐regulating C DK6 by i nterac…