Explanipedia

Identification of plasma extracellular vesicle protein biomarkers in diabetic retinopathy progression Open

Zhen Li, Xiaojing Pang, Hang Wu, Jie Zhang, Zhili Wang · 2025

Protein biomarkers from plasma extracellular vesicles (EVs) have been extensively identified in various diseases. To explore biomarkers associated with diabetic retinopathy (DR) progression, we designed two cohorts, discovery and validatio…

The research progress of SARS-CoV-2 main protease inhibitors from 2020 to 2022 Open

Xiaojing Pang, Wei Xu, Yang Liu, Hua Li, Lixia Chen · 2023

Progress in the development of small molecular inhibitors of the Bruton’s tyrosine kinase (BTK) as a promising cancer therapy Open

Xiujuan Liu, Xu-Liu, Xiaojing Pang, Xin -Ying Yuan, Guang-Xi Yu , et al. · 2021

Drug Discovery Targeting Focal Adhesion Kinase (FAK) as a Promising Cancer Therapy Open

Xiaojing Pang, Xiujuan Liu, Yuan Liu, Wenbo Liu, Yin-Ru Li , et al. · 2021

FAK is a nonreceptor intracellular tyrosine kinase which plays an important biological function. Many studies have found that FAK is overexpressed in many human cancer cell lines, which promotes tumor cell growth by controlling cell adhesi…

Discovery of Novel Diarylamide N-Containing Heterocyclic Derivatives as New Tubulin Polymerization Inhibitors with Anti-Cancer Activity Open

Xu Liu, Xiaojing Pang, Yuan Liu, Wen‐Bo Liu, Yin-Ru Li , et al. · 2021

Tubulin has been regarded as an attractive and successful molecular target in cancer therapy and drug discovery. Vicinal diaryl is a simple scaffold found in many colchicine site tubulin inhibitors, which is also an important pharmacophori…

Design, Synthesis and Anticancer Activity Studies of Novel Indole-Pyrimidine Biaryl Derivatives Open

Danqing Zhang, Xu Liu, Xiaojing Pang, Hong‐Min Liu, Qiurong Zhang · 2021

c ( a 郑州大学药学院郑州 450001) ( b 新药创制与药物安全性评价河南省协同创新中心郑州 450001) ( c 教育部药物制备关键技术重点实验室郑州 450001) 摘要设计合成了一系列新型的吲哚-嘧啶联芳类化合物, 并评估了它们对组蛋白去甲基化酶(LSD1)的抑制活性和 5 种肿瘤细胞系(MGC-803, PC-3, EC-109, PC-12 和 MCF-7)的抗增殖活性.探讨了 22 个新型吲哚-嘧啶联芳类骨架衍生物的主要构效关系.在这些化合…

Synthesis and Biological Evaluation of Amino Chalcone Derivatives as Antiproliferative Agents Open

Chao-Fan Lu, Shenghui Wang, Xiaojing Pang, Ting Zhu, Hongli Li , et al. · 2020

Chalcone is a common scaffold found in many biologically active compounds. The chalcone scaffold was also frequently utilized to design novel anticancer agents with potent biological efficacy. Aiming to continue the research of effective c…

Synthesis and Anticancer Activity of Novel Coumarin Derivatives Open

Lei Shi, Ziqiu Li, Xinxin Cui, Ting Zhu, Xiaojing Pang , et al. · 2020

c ( a 郑州大学化学学院郑州 450001) ( b 郑州大学药学院郑州 450001) ( c 郑州大学基础医学院郑州 450001) 摘要为了寻找结构新颖、活性较好的抗肿瘤化合物, 设计合成了 19 个未见文献报道的 3,4,5-三甲氧基苯基香豆素类化合物, 并用核磁共振(NMR)和高分辨质谱(HRMS)等方法对化合物结构进行表征.用四甲基偶氮唑盐(MTT)法评价了该类化合物对人前列腺癌细胞(PC-3)、人食管癌细胞(EC-109)和人胃癌细胞(MGC-…

Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking Open

Lin Zhang, Hao Shen, Yiyi Gong, Xiaojing Pang, Meiqi Yi , et al. · 2019

Long peptide DCAF enables high selectivity to target harmful antibodies, providing new thoughts for antibody-induced disease intervention.

Monoclonal antibody-based colloid gold immunochromatographic strip for the rapid detection of Tomato zonate spot tospovirus Open

Yanbing Niu, Defu Wang, Liyan Cui, Baoxia Wang, Xiaojing Pang , et al. · 2018

Molecular detection of watermelon mosaic virus associated with a serious mosaic disease on Cucurbita pepo L. in Shanxi, China Open

Yanbing Niu, Xiaojing Pang, Y CHENG, Defu Wang, Shang Guo , et al. · 2017

A Mesh–Duox pathway regulates homeostasis in the insect gut Open

Xiaoping Xiao, Lijuan Yang, Xiaojing Pang, Rudian Zhang, Yibin Zhu , et al. · 2017

Regulation of Antimicrobial Peptides in Aedes aegypti Aag2 Cells Open

Rudian Zhang, Yibin Zhu, Xiaojing Pang, Xiaoping Xiao, Renli Zhang , et al. · 2017

Antimicrobial peptides (AMPs) are an important group of immune effectors that play a role in combating microbial infections in invertebrates. Most of the current information on the regulation of insect AMPs in microbial infection have been…

Progress towards understanding the pathogenesis of denguehemorrhagic fever Open

Xiaojing Pang, Rudian Zhang, Gong Cheng · 2016

Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical sym…

Flavivirus NS1 protein in infected host sera enhances viral acquisition by mosquitoes Open

Jianying Liu, Yang Liu, Kaixiao Nie, Senyan Du, Jingjun Qiu , et al. · 2016

Mosquito C-type lectins maintain gut microbiome homeostasis Open

Xiaojing Pang, Xiaoping Xiao, Yang Liu, Rudian Zhang, Jianying Liu , et al. · 2016

Association of LINE-1 RNP with stress granule marker G3BP1. Open

Siqi Hu, Li Jian, Fengwen Xu, Shan Mei, Le Duff Yann , et al. · 2015

(A) Schematic illustration of the immunoprecipitation/RT-PCR protocol. LINE-1 RNA that was co-immunoprecipitated (IP) was measured by nest RT-PCR. The PCR products were analyzed by gel electrophoresis followed by extraction from the gel an…

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation Open

Siqi Hu, Jian Li, Fengwen Xu, Shan Mei, Yann Le Duff , et al. · 2015

The SAM domain and HD domain containing protein 1 (SAMHD1) inhibits retroviruses, DNA viruses and long interspersed element 1 (LINE-1). Given that in dividing cells, SAMHD1 loses its antiviral function yet still potently restricts LINE-1, …

A Neuron-Specific Antiviral Mechanism Prevents Lethal Flaviviral Infection of Mosquitoes Open

Xiaoping Xiao, Rudian Zhang, Xiaojing Pang, Guodong Liang, Penghua Wang , et al. · 2015

Mosquitoes are natural vectors for many etiologic agents of human viral diseases. Mosquito-borne flaviviruses can persistently infect the mosquito central nervous system without causing dramatic pathology or influencing the mosquito behavi…

The Roles of Direct Recognition by Animal Lectins in Antiviral Immunity and Viral Pathogenesis Open

Yang Liu, Jianying Liu, Xiaojing Pang, Tao Liu, Zhijie Ning , et al. · 2015

Lectins are a group of proteins with carbohydrate recognition activity. Lectins are categorized into many families based on their different cellular locations as well as their specificities for a variety of carbohydrate structures due to t…

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