Jingyi Cao
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View article: Single-cell splicing QTL analysis in pancreatic islets
Single-cell splicing QTL analysis in pancreatic islets Open
Introduction Alternative splicing (AS) of mRNAs is a highly conserved mechanism which can greatly expand the functional diversity of the transcriptome. Aberrant splicing underpins many diseases, and a better understanding of AS can provide…
View article: The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer
The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer Open
Nerves are an integral component of the tumor microenvironment, contributing to cancer progression, metastasis, morbidity, and mortality. In pancreatic ductal adenocarcinoma (PDAC), worse clinical outcomes are associated with perineural in…
View article: Copy number variations in urine cell-free DNA from bladder neoplasm patients
Copy number variations in urine cell-free DNA from bladder neoplasm patients Open
Bladder cancer is a common malignancy, and its diagnosis is based on invasive procedures such as cystoscopy. Genetic aberrations play an important role in the development of many diseases, including bladder cancer. As a result, identifying…
View article: Protein Tyrosine Kinase 2 Circular RNA Promotes Proliferation and Invasion of Bladder Cancer
Protein Tyrosine Kinase 2 Circular RNA Promotes Proliferation and Invasion of Bladder Cancer Open
Background/Aims: Bladder cancer is a type of malignant tumor that disrupts normal urinary function in patients, thereby significantly impacting their quality of life. This disease also imposes a heavy economic burden on both patients and p…
View article: Tumor hypoxia: Classification, detection, and its critical role in cancer progression
Tumor hypoxia: Classification, detection, and its critical role in cancer progression Open
Hypoxia is a common feature of solid tumors and plays a critical role in cancer progression. A thorough understanding of tumor hypoxia is essential for gaining deeper insights into various aspects of cancer biology. This review examines th…
View article: InSituCor: exploring spatially correlated genes conditional on the cell type landscape
InSituCor: exploring spatially correlated genes conditional on the cell type landscape Open
In spatial transcriptomics data, spatially correlated genes promise to reveal high-interest phenomena like cell–cell interactions and latent variables. But in practice, most spatial correlations arise from the spatial arrangement of cell t…
View article: Circulating bile acid profiles characteristics and the potential predictive role in clear cell renal cell carcinoma progression
Circulating bile acid profiles characteristics and the potential predictive role in clear cell renal cell carcinoma progression Open
Not applicable.
View article: Design a Novel Polymeric Heart Valve PHV‐SH and Test the Feasibility Using in Vivo Pre‐Clinical Non‐inferiority Trial
Design a Novel Polymeric Heart Valve PHV‐SH and Test the Feasibility Using in Vivo Pre‐Clinical Non‐inferiority Trial Open
Polymeric heart valves (PHVs) present a promising alternative to mechanical and bio‐prosthetic valves, addressing critical issues such as durability and calcification. This study investigates poly(styrene‐block‐ethylene/butylene‐block‐styr…
View article: Visible‐Light‐Mediated Synthesis of 3‐Chlorobenzo[<i>b</i>]thiophenes Using Polychloromethanes as Solvent and Halogen Source
Visible‐Light‐Mediated Synthesis of 3‐Chlorobenzo[<i>b</i>]thiophenes Using Polychloromethanes as Solvent and Halogen Source Open
This study developed a novel strategy based on visible‐light photocatalysis for the construction of 3‐chlorobenzo[ b ]thiophenes. The photocatalytic system exhibits multiple advantages, including mild reaction conditions, cascade reaction,…
View article: Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K/AKT signaling pathway
Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K/AKT signaling pathway Open
Triphenyl phosphate (TPHP) is a widely used organic phosphate flame retardant that has been reported as a potential environmental obesogen. However, the potential impact and mechanism of action of TPHP on adipose tissue are still unclear. …
View article: Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs
Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs Open
Background/Objectives: The endosomal escape of lipid nanoparticles (LNPs) is crucial for efficient mRNA-based therapeutics. Here, we present a cationic polymeric micelle (cPM) as a safe and potent co-delivery system with enhanced endosomal…
View article: Weak Fiber Bragg Grating Array-Based In Situ Flow and Defects Monitoring During the Vacuum-Assisted Resin Infusion Process
Weak Fiber Bragg Grating Array-Based In Situ Flow and Defects Monitoring During the Vacuum-Assisted Resin Infusion Process Open
Monitoring of real-time flow and defects in the vacuum-assisted resin infusion (VARI) process can provide important guidelines for full impregnation of dry reinforcement. A weak fiber Bragg grating array was employed to obtain quasi-distri…
View article: Bending Failure Behavior of Thin-walled Composite Tube Structures
Bending Failure Behavior of Thin-walled Composite Tube Structures Open
The bending failure, failure load and failure mode of thin-walled circular tubes made of carbon fiber reinforced resin matrix composites were investigated by experiments and numerical simulation. Three typical failure modes of circular tub…
View article: Correlations Between Metformin and Prognosis and Adverse Reactions in Patients Undergoing Radical Cystectomy Followed by Adjuvant GC Chemotherapy for Bladder Cancer
Correlations Between Metformin and Prognosis and Adverse Reactions in Patients Undergoing Radical Cystectomy Followed by Adjuvant GC Chemotherapy for Bladder Cancer Open
Objective The objective of this research was to examine the influence of metformin on both prognosis and adverse reactions in patients who have undergone radical cystectomy (RC) and subsequently received adjuvant gemcitabine and cisplatin …
View article: Study on Failure Behavior of Composite Single Nail Link Structure
Study on Failure Behavior of Composite Single Nail Link Structure Open
When the composite laminate single nail connector is subjected to 60,000 cycles under an alternating cyclic tensile load of 7∼9KN, the specimen is damaged. The cause of the failure sample was determined through macroscopic and microscopic …
View article: Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment
Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment Open
View article: Subregion-specific transcriptomic profiling of rat brain reveals sex-distinct gene expression impacted by adolescent stress
Subregion-specific transcriptomic profiling of rat brain reveals sex-distinct gene expression impacted by adolescent stress Open
View article: Analysis of Biodistribution and in vivo Toxicity of Varying Sized Polystyrene Micro and Nanoplastics in Mice
Analysis of Biodistribution and in vivo Toxicity of Varying Sized Polystyrene Micro and Nanoplastics in Mice Open
The biological distribution and toxicity of plastic particles in mice were more obvious with the decrease of particle size and the increase of concentration of plastic particles. Compared with MPs, NPs were easier to enter the tissues and …
View article: Overview on Approaches to Integrate Chinese Culture into English Teaching
Overview on Approaches to Integrate Chinese Culture into English Teaching Open
Given the current situation where English textbooks used in the joint training program of higher vocational colleges lack sufficient representation of Chinese culture, it becomes imperative to incorporate elements of Chinese culture into E…
View article: Potent cancer therapy by liposome microstructure tailoring with active-to-passive targeting and shell-to-core thermosensitive features
Potent cancer therapy by liposome microstructure tailoring with active-to-passive targeting and shell-to-core thermosensitive features Open
Liposomes have been widely studied as drug carriers for clinical application, and the key issue is how to achieve effective delivery through targeting strategies. Even though certain cell-level targeting or EPR effect designs have been dev…
View article: Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution
Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution Open
Background Tumors are able to acquire new capabilities, including traits such as drug resistance and metastasis that are associated with unfavorable clinical outcomes. Single-cell technologies have made it possible to study both mutational…
View article: P12.07 AI-enhanced quantitative assessment of T cell cytotoxicity using label-free live-cell imaging on micro-pattern for high-throughput investigation of T cell quality and moderation by tumor microenvironment
P12.07 AI-enhanced quantitative assessment of T cell cytotoxicity using label-free live-cell imaging on micro-pattern for high-throughput investigation of T cell quality and moderation by tumor microenvironment Open
Background T cell cytotoxicity plays a crucial role in defending against cancer. It is traditionally assessed by endpoint assays with non-microscopic appliance, thus lacking temporal and visual insights into middle time ranges that live-ce…
View article: A New Strategy for the High-Throughput Characterization of Materials’ Mechanical Homogeneity Based on the Effect of Isostatic Pressing on Surface Microstrain
A New Strategy for the High-Throughput Characterization of Materials’ Mechanical Homogeneity Based on the Effect of Isostatic Pressing on Surface Microstrain Open
A new strategy for the high-throughput characterization of the mechanical homogeneity of metallurgical materials is proposed. Based on the principle of hydrostatic transmission and the synergistic analysis of the composition, microstructur…
View article: An Approximate Method for Natural Frequency Analysis of Variable-Pitch Vertical Axis Wind Turbine Blades
An Approximate Method for Natural Frequency Analysis of Variable-Pitch Vertical Axis Wind Turbine Blades Open
View article: Progress in Marine Antifouling Coatings: Current Status and Prospects
Progress in Marine Antifouling Coatings: Current Status and Prospects Open
The shipping industry is vital to global trade. Unfortunately, this industry is negatively impacted on a large scale by biofouling, a process whereby unwanted organisms accumulate on submerged surfaces, massively affecting traveling speed …
View article: Parathyroid hormone-related protein as a potential prostate cancer biomarker: Promoting prostate cancer progression through upregulation of c-Met expression
Parathyroid hormone-related protein as a potential prostate cancer biomarker: Promoting prostate cancer progression through upregulation of c-Met expression Open
Parathyroid hormone-related protein (PTHrP) plays a significant role in various tumor types, including prostate cancer. However, its specific role and underlying mechanisms in prostate cancer remain unclear. This study investigates the rol…
View article: Security label and attribute-based access control in service-oriented environments
Security label and attribute-based access control in service-oriented environments Open
Compared with traditional systems, service-oriented environments are more dynamic and distributed. Although traditional access control is able to fulfill the security of requirements of closed systems on the whole, it can no longer meet th…
View article: Intercellular Mechanisms of Therapeutic Resistance at the Tumor-Stromal Interface Using Ultra High-Plex Single-Cell Spatial Transcriptomics and Genetically-Engineered Tumoroids
Intercellular Mechanisms of Therapeutic Resistance at the Tumor-Stromal Interface Using Ultra High-Plex Single-Cell Spatial Transcriptomics and Genetically-Engineered Tumoroids Open
View article: Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis
Therapy-associated remodeling of pancreatic cancer revealed by single-cell spatial transcriptomics and optimal transport analysis Open
In combination with cell intrinsic properties, interactions in the tumor microenvironment modulate therapeutic response. We leveraged high-plex single-cell spatial transcriptomics to dissect the remodeling of multicellular neighborhoods an…
View article: PDAC-SMI transcript locations
PDAC-SMI transcript locations Open
This record contains the spatial locations of transcripts in the PDAC-SMI data.