Jingan Chen
YOU?
Author Swipe
View article: Integrating RNA-Seq and Metabolomic Perspectives Reveals the Mechanism of Response to Phosphorus Stress of Potamogeton wrightii
Integrating RNA-Seq and Metabolomic Perspectives Reveals the Mechanism of Response to Phosphorus Stress of Potamogeton wrightii Open
Phosphorus is an important nutrient element in aquatic ecosystems, and its concentration directly affects the growth and ecological functions of submerged plants. However, the physiological and molecular mechanisms of P. wrightii’s respons…
View article: Relationship between anthropogenic factors and freshwater quality in Hainan Province, south China
Relationship between anthropogenic factors and freshwater quality in Hainan Province, south China Open
View article: Pathological and Structural Alterations of the Visual Pathway in APP/PS1 Mice: A Spatiotemporal Analysis
Pathological and Structural Alterations of the Visual Pathway in APP/PS1 Mice: A Spatiotemporal Analysis Open
Background/Objectives: Visual dysfunction emerges during the mild cognitive impairment stage of early Alzheimer’s disease (AD). While previous studies have primarily focused on retinal pathology, the early pathological progression across c…
View article: Response of bacterioplankton communities and their phosphorus metabolic functions to algal extinction and growth in a eutrophic plateau lake
Response of bacterioplankton communities and their phosphorus metabolic functions to algal extinction and growth in a eutrophic plateau lake Open
View article: A Reverse Transcription Nucleic-Acid-Based Barcoding System for <i>In Vivo</i> Measurement of Lipid Nanoparticle mRNA Delivery
A Reverse Transcription Nucleic-Acid-Based Barcoding System for <i>In Vivo</i> Measurement of Lipid Nanoparticle mRNA Delivery Open
Lipid nanoparticles (LNPs) are the most extensively validated clinical delivery vehicles for mRNA therapeutics, exemplified by their widespread use in the mRNA COVID-19 vaccines. The pace of lipid nanoparticle (LNP) development for mRNA th…
View article: Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery
Rational design and modular synthesis of biodegradable ionizable lipids via the Passerini reaction for mRNA delivery Open
The ionizable lipid component of lipid nanoparticle (LNP) formulations is essential for mRNA delivery by facilitating endosomal escape. Conventionally, these lipids are synthesized through complex, multistep chemical processes that are bot…
View article: Non-Point Source Pollution Risk Assessment in Karst Basins: Integrating Source–Sink Landscape Theory and Soil Erosion Modeling
Non-Point Source Pollution Risk Assessment in Karst Basins: Integrating Source–Sink Landscape Theory and Soil Erosion Modeling Open
Non-point source pollution poses a significant threat to global water security, and risk assessment and key source area (CSA) identification are critical for its management. While source–sink landscape models are widely used for non-point …
View article: Characteristics and mechanisms of particulate organic phosphorus release during the vigorous growth period of algae in sub-deep reservoirs with different trophic levels
Characteristics and mechanisms of particulate organic phosphorus release during the vigorous growth period of algae in sub-deep reservoirs with different trophic levels Open
View article: Green Chemical Upcycling Phosphogypsum for Nano-Calcium Carbonate Synthesis and Synergistic Co2 Capture
Green Chemical Upcycling Phosphogypsum for Nano-Calcium Carbonate Synthesis and Synergistic Co2 Capture Open
View article: Characteristics and Mechanisms of Particulate Organic Phosphorus Release During the Vigorous Growth Period of Algae in Sub-Deep Reservoirs with Different Trophic Levels
Characteristics and Mechanisms of Particulate Organic Phosphorus Release During the Vigorous Growth Period of Algae in Sub-Deep Reservoirs with Different Trophic Levels Open
View article: Characteristics and Mechanisms of Particulate Organic Phosphorus Release During the Vigorous Growth Period of Algae in Sub-Deep Reservoirs with Different Trophic Levels
Characteristics and Mechanisms of Particulate Organic Phosphorus Release During the Vigorous Growth Period of Algae in Sub-Deep Reservoirs with Different Trophic Levels Open
View article: Distribution and Risk Assessment of Microplastics in the Basin of the Pearl River, China
Distribution and Risk Assessment of Microplastics in the Basin of the Pearl River, China Open
View article: Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects
Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects Open
Ionizable lipid nanoparticles (LNPs) pivotal to the success of COVID-19 mRNA (messenger RNA) vaccines hold substantial promise for expanding the landscape of mRNA-based therapies. Nevertheless, the risk of mRNA delivery to off-target tissu…
View article: External Application of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Hyaluronic Acid Gel Repairs Foot Wounds of Types I and II Diabetic Rats Through Paracrine Action Mode
External Application of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Hyaluronic Acid Gel Repairs Foot Wounds of Types I and II Diabetic Rats Through Paracrine Action Mode Open
Diabetic foot ulcer (DFU) is a main diabetic complication with unmet treatment needs. This study applied human umbilical cord-derived mesenchymal stem cells-hyaluronic acid (hucMSCs-HA) gel to treat DFU in a noninvasive external way and in…
View article: Ecological-health risks assessment and characteristic pollutants identification of heavy metals in the soils of a coking plant in production in Guangxi, China
Ecological-health risks assessment and characteristic pollutants identification of heavy metals in the soils of a coking plant in production in Guangxi, China Open
In response to the detailed investigation in the production enterprise by the Ministry of Ecology and Environment of the People's Republic of China, The investigation of soil pollution potential risk in a coking welfare plant in Liuzhou wa…
View article: AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery
AGILE Platform: A Deep Learning-Powered Approach to Accelerate LNP Development for mRNA Delivery Open
Ionizable lipid nanoparticles (LNPs) have seen widespread use in mRNA delivery for clinical applications, notably in SARS-CoV-2 mRNA vaccines. Despite their successful use, expansion of mRNA therapies beyond COVID-19 is impeded by the abse…
View article: Intravenous injection of human umbilical cord-derived mesenchymal stem cells ameliorates not only blood glucose but also nephrotic complication of diabetic rats through autophagy-mediated anti-senescent mechanism
Intravenous injection of human umbilical cord-derived mesenchymal stem cells ameliorates not only blood glucose but also nephrotic complication of diabetic rats through autophagy-mediated anti-senescent mechanism Open
View article: Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma (DBA/2J) mice
Morphological disruption and visual tuning alterations in the primary visual cortex in glaucoma (DBA/2J) mice Open
Glaucoma is a leading cause of irreversible blindness worldwide, and previous studies have shown that, in addition to affecting the eyes, it also causes abnormalities in the brain. However, it is not yet clear how the primary visual cortex…
View article: Table of Contents
Table of Contents Open
View article: The effects of socioeconomic activities on water quality in Hainan Island, south China
The effects of socioeconomic activities on water quality in Hainan Island, south China Open
Water quality is intimately related to the livelihood of the numerous people, and affects the development and operating benefits of various industries in society. This study clarifies the effects of human-driven economic activities on inla…
View article: Optical properties as indicators of in-lake dissolved organic matter components, sources and transformation
Optical properties as indicators of in-lake dissolved organic matter components, sources and transformation Open
Dissolved organic matter (DOM) plays an essential role in the biogeochemical cycle of carbon (C) in inland lakes. Combining ultraviolet–visible (UV–vis) absorption and fluorescence spectroscopy–parallel factor analysis (PARAFAC), we examin…
View article: Plateau Lake Water Quality and Eutrophication: Status and Challenges
Plateau Lake Water Quality and Eutrophication: Status and Challenges Open
The continuous and widespread deterioration of lake water quality and eutrophication is not only a local problem, but also a global phenomenon [...]
View article: Effective Removal of Nitrogen and Phosphorus from a Black-Odorous Water by Novel Oxygen-Loaded Adsorbents
Effective Removal of Nitrogen and Phosphorus from a Black-Odorous Water by Novel Oxygen-Loaded Adsorbents Open
View article: Spatial Variation of Soil Phosphorus in the Water Level Fluctuation Zone of the Three Gorges Reservoir: Coupling Effects of Elevation and Artificial Restoration
Spatial Variation of Soil Phosphorus in the Water Level Fluctuation Zone of the Three Gorges Reservoir: Coupling Effects of Elevation and Artificial Restoration Open
View article: Corn Stigma Ameliorates Hyperglycemia in Zebrafish And Gk Rats of Type 2 Diabetes
Corn Stigma Ameliorates Hyperglycemia in Zebrafish And Gk Rats of Type 2 Diabetes Open
View article: Do Honored Cities Achieve a Sustainable Development? A Quasi-Natural Experimental Study Based on “National Civilized City” Campaign in China
Do Honored Cities Achieve a Sustainable Development? A Quasi-Natural Experimental Study Based on “National Civilized City” Campaign in China Open
As a new model of urban governance with Chinese characteristics, the national honored cities from city evaluation competitions, represented by the “National Civilized City” campaign, has always been popular among Chinese cities. Can the ho…
View article: Identification of six hub genes and two key pathways in two rat renal fibrosis models based on bioinformatics and RNA-seq transcriptome analyses
Identification of six hub genes and two key pathways in two rat renal fibrosis models based on bioinformatics and RNA-seq transcriptome analyses Open
Renal fibrosis (RF) is the common pathological manifestation and central treatment target of multiple chronic kidney diseases with high morbidity and mortality. Currently, the molecular mechanisms underlying RF remain poorly understood, an…
View article: Human umbilical cord-derived mesenchymal stem cells not only ameliorate blood glucose but also protect vascular endothelium from diabetic damage through a paracrine mechanism mediated by MAPK/ERK signaling
Human umbilical cord-derived mesenchymal stem cells not only ameliorate blood glucose but also protect vascular endothelium from diabetic damage through a paracrine mechanism mediated by MAPK/ERK signaling Open
Background Endothelial damage is an initial step of macro- and micro-vasculature dysfunctions in diabetic patients, accounting for a high incidence of diabetic vascular complications, such as atherosclerosis, nephropathy, retinopathy, and …
View article: Effect of Ecosystem Degradation on the Source of Particulate Organic Matter in a Karst Lake: A Case Study of the Caohai Lake, China
Effect of Ecosystem Degradation on the Source of Particulate Organic Matter in a Karst Lake: A Case Study of the Caohai Lake, China Open
The cycle of biogenic elements in lakes is intimately linked with particulate organic matter (POM), which plays a critical role in ecosystem restoration and the control of eutrophication. However, little is known regarding the functionalit…
View article: Synergistic Effects and Ecological Responses of Combined In Situ Passivation and Macrophytes toward the Water Quality of a Macrophytes-Dominated Eutrophic Lake
Synergistic Effects and Ecological Responses of Combined In Situ Passivation and Macrophytes toward the Water Quality of a Macrophytes-Dominated Eutrophic Lake Open
Combined use of in situ passivation and macrophytes is a valuable technology that exerts remarkable effects on aquatic systems. However, the effectiveness and ecological functions of this combined technology for macrophytes-dominated eutro…