Yufei Zhang
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View article: Bridging Discrete and Continuous RL: Stable Deterministic Policy Gradient with Martingale Characterization
Bridging Discrete and Continuous RL: Stable Deterministic Policy Gradient with Martingale Characterization Open
The theory of discrete-time reinforcement learning (RL) has advanced rapidly over the past decades. Although primarily designed for discrete environments, many real-world RL applications are inherently continuous and complex. A major chall…
View article: Risk factors and nomogram for predicting mechanical ventilation in severe pneumonia
Risk factors and nomogram for predicting mechanical ventilation in severe pneumonia Open
Background Severe pneumonia often leads to acute respiratory failure requiring mechanical ventilation (MV), significantly increasing patient morbidity and mortality. Early prediction of MV requirement could optimize patient management and …
View article: CD147 mediates the adsorption of influenza A virus on the cell surface through direct interaction with HA
CD147 mediates the adsorption of influenza A virus on the cell surface through direct interaction with HA Open
The adsorption of avian influenza virus (AIV) initiates the viral lifecycle, determining host tropism and pathogenicity. In addition to the classical AIV receptor, auxiliary receptors also play important roles in viral adsorption, though t…
View article: Controllable preparation and toluene adsorption performance of ZSM-5 zeolites with different Si/Al ratios
Controllable preparation and toluene adsorption performance of ZSM-5 zeolites with different Si/Al ratios Open
This study employed a hydrothermal approach to prepare ZSM-5 zeolites with varying Si/Al ratios (Si/Al = 25, 50, 90, 165, 260, and pure siliceous). These were prepared in a controlled manner using ethyl orthosilicate as the silica source, …
View article: Mn-Doped CeO2 Nanozyme-Integrated Mesoporous Interfaces for High-Sensitivity Antifouling Electrochemiluminescence Biosensing
Mn-Doped CeO2 Nanozyme-Integrated Mesoporous Interfaces for High-Sensitivity Antifouling Electrochemiluminescence Biosensing Open
To address the challenges of nonspecific adsorption interference and low mass transfer efficiency encountered by electrochemiluminescence (ECL) sensors in complex biological matrices, this study developed a Mn@CeO2 nanozyme-based sensing i…
View article: Coupling Zn<sup>2+</sup> Ferrying Effect With Anion–π Interaction to Mitigate Space Charge Layer Enables Ultra‐High Utilization Rate Zn Anode
Coupling Zn<sup>2+</sup> Ferrying Effect With Anion–π Interaction to Mitigate Space Charge Layer Enables Ultra‐High Utilization Rate Zn Anode Open
A major dilemma faced by Zn anodes at a high zinc utilization rate (ZUR) is the insufficient supply of ionic carriers that initiate the space charge layer (SCL) subject to the rampant growth of Zn dendrites. Herein, an “anion–cation co‐reg…
View article: Experimental Study of Permeability Characteristic of Porous Asphalt Mixtures During Clogging and Cleaning
Experimental Study of Permeability Characteristic of Porous Asphalt Mixtures During Clogging and Cleaning Open
Pore clogging in porous asphalt pavement (PAP) severely limits its functional performance and widespread application. This study systematically investigates the permeability degradation and recovery characteristics of seven porous asphalt …
View article: Diagnostic Value of Glycosylated Extracellular Vesicle microRNAs in Gastric Cancer
Diagnostic Value of Glycosylated Extracellular Vesicle microRNAs in Gastric Cancer Open
The model demonstrated high sensitivity and specificity in diagnosing patients with GC, especially in differentiating early-stage GC from benign patients. The five miRNA pairs could also aid in making treatment decisions. Thus, miRNAs deri…
View article: A Thermodynamic Perspective on the Efficient Pressure Potential Energy Release in an Ice-Assisted Near-Isothermal Caes System
A Thermodynamic Perspective on the Efficient Pressure Potential Energy Release in an Ice-Assisted Near-Isothermal Caes System Open
View article: Elucidating Sulfur Reduction Reaction Kinetics Via Polysulfide Concentration Modulation: Toward High-Performance Lithium-Sulfur Batteries
Elucidating Sulfur Reduction Reaction Kinetics Via Polysulfide Concentration Modulation: Toward High-Performance Lithium-Sulfur Batteries Open
View article: Regulating Zn Deposition Manner by Confining the Reactivity of Free Water in the Electric Double Layer
Regulating Zn Deposition Manner by Confining the Reactivity of Free Water in the Electric Double Layer Open
Aqueous Zn ion batteries (AZIBs) are promising candidates of next‐generation energy storage devices with high safety and theoretical capacity. However, the irreversibility of metallic Zn anode, attributed to dendrite growth and water decom…
View article: Molecular characteristics, risk factors, and clinical outcomes of methicillin-resistant Staphylococcus aureus infections among critically ill pediatric patients in Shanghai, 2016–2021
Molecular characteristics, risk factors, and clinical outcomes of methicillin-resistant Staphylococcus aureus infections among critically ill pediatric patients in Shanghai, 2016–2021 Open
Objective Methicillin-resistant Staphylococcus aureus (MRSA) infection in children has been on the rise, which poses a serious threat to their health and life in China. The purpose of this study was to determine the molecular characteristi…
View article: Diagnosis and treatment of anterior cruciate ligament injuries: Consensus of Chinese experts part II: Graft selection and clinical outcome evaluation
Diagnosis and treatment of anterior cruciate ligament injuries: Consensus of Chinese experts part II: Graft selection and clinical outcome evaluation Open
The consensus clearly states that ACL reconstruction has no definitive "gold standard" graft choice. Autografts have advantages in healing capability but are limited in availability and have potential donor site morbidities; allografts red…
View article: Molecular Bridging Induced Anti‐Salting‐Out Effect Enabling High Ionic Conductive ZnSO<sub>4</sub>‐Based Hydrogel for Quasi‐Solid‐State Zinc Ion Batteries
Molecular Bridging Induced Anti‐Salting‐Out Effect Enabling High Ionic Conductive ZnSO<sub>4</sub>‐Based Hydrogel for Quasi‐Solid‐State Zinc Ion Batteries Open
Hydrogel electrolytes (HEs) hold great promise in tackling severe issues emerging in aqueous zinc‐ion batteries, but the prevalent salting‐out effect of kosmotropic salt causes low ionic conductivity and electrochemical instability. Herein…
View article: The role and mechanism of cinnamaldehyde in cancer
The role and mechanism of cinnamaldehyde in cancer Open
As cancer continues to rise globally, there is growing interest in discovering novel methods for prevention and treatment. Due to the limitations of traditional cancer therapies, there has been a growing emphasis on investigating herbal re…
View article: Environmentally Friendly Slurry of Using Ceo2/Mos2 Mixed Abrasives in Quartz Glass Chemical Mechanical Polishing
Environmentally Friendly Slurry of Using Ceo2/Mos2 Mixed Abrasives in Quartz Glass Chemical Mechanical Polishing Open
View article: Multifunctional Self-Supporting Llto/C Interlayer for High-Performance Lithium-Sulfur Battery
Multifunctional Self-Supporting Llto/C Interlayer for High-Performance Lithium-Sulfur Battery Open
View article: Insights into the epidemiology, risk factors, and clinical outcomes of carbapenem-resistant Acinetobacter baumannii infections in critically ill children
Insights into the epidemiology, risk factors, and clinical outcomes of carbapenem-resistant Acinetobacter baumannii infections in critically ill children Open
Background and aims Carbapenem-resistant Acinetobacter baumannii (CRAB) has become a leading cause of nosocomial infections with an increasing impact on critically ill patients, yet there is limited data on contributing factors. This study…
View article: Applications of Serine Integrases in Synthetic Biology over the Past Decade
Applications of Serine Integrases in Synthetic Biology over the Past Decade Open
Serine integrases are emerging as one of the most powerful biological tools for biotechnology. Over the past decade, many research papers have been published on the use of serine integrases in synthetic biology. In this review, we aim to s…
View article: Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription
Fluid shear stress-modulated chromatin accessibility reveals the mechano-dependency of endothelial SMAD1/5-mediated gene transcription Open
Bone morphogenetic protein (BMP) signaling and fluid shear stress (FSS) mediate complementary functions in vascular homeostasis and disease development. It remains to be shown whether altered chromatin accessibility downstream of BMP and F…
View article: Safety, Efficacy, and Immunogenicity of Endoscopic Cryoballoon Ablation Therapy in Patients with Advanced Gastric Cancer: A First-in-Human Clinical Trial
Safety, Efficacy, and Immunogenicity of Endoscopic Cryoballoon Ablation Therapy in Patients with Advanced Gastric Cancer: A First-in-Human Clinical Trial Open
View article: Diagnostic Value of Glycosylated Exosomal microRNAs in Gastric Cancer
Diagnostic Value of Glycosylated Exosomal microRNAs in Gastric Cancer Open
View article: Designing Multidimensional Hydration Inhibitor Towards Long Cycling Performance of Zinc Powder Anode
Designing Multidimensional Hydration Inhibitor Towards Long Cycling Performance of Zinc Powder Anode Open
View article: Atomic-Thick Porous Pd Nanosheets with Antioxidant Enzyme-Like Activities and Photothermal Properties for Potential Alzheimer's Disease Treatment
Atomic-Thick Porous Pd Nanosheets with Antioxidant Enzyme-Like Activities and Photothermal Properties for Potential Alzheimer's Disease Treatment Open
View article: The Near Surface Damage and Recovery Of Low Nitrogen Diamond Implanted with Mev Phosphorus Ions
The Near Surface Damage and Recovery Of Low Nitrogen Diamond Implanted with Mev Phosphorus Ions Open
View article: Involvement of testicular N-glycoproteome heterogeneity in seasonal spermatogenesis of the American mink (Neovison vison)
Involvement of testicular N-glycoproteome heterogeneity in seasonal spermatogenesis of the American mink (Neovison vison) Open
Spermatogenesis in the American mink is characterized by an annual cycle of transition involving completely inactive and fully activated stages. N-glycosylation of proteins has emerged as an important regulator as it affects protein foldin…
View article: Advances in the therapy of cerebral ischemia-reperfusion injury with natural product-based nanoparticles
Advances in the therapy of cerebral ischemia-reperfusion injury with natural product-based nanoparticles Open
Stroke is a serious acute cerebrovascular disease attributable to disruptions in the blood supply to the brain tissue as a result of vascular obstruction or sudden rupture of blood vessels in the brain, which further result in hypoxia of t…
View article: Hotspots of single-strand DNA “breakome” are enriched at transcriptional start sites of genes
Hotspots of single-strand DNA “breakome” are enriched at transcriptional start sites of genes Open
Single-strand breaks (SSBs) represent one of the most common types of DNA damage, yet not much is known about the genome landscapes of this type of DNA lesions in mammalian cells. Here, we found that SSBs are more likely to occur in certai…
View article: Athlete students lead a healthier life than their non-athlete peers: A cross-sectional study of health behaviors, depression, and perceived health status among university students
Athlete students lead a healthier life than their non-athlete peers: A cross-sectional study of health behaviors, depression, and perceived health status among university students Open
Some studies show that athlete students are more likely to engage in health-risk behaviors with negative health consequences, while others suggest that they lead a healthier life than their non-athlete peers. Given these inconsistent resul…
View article: Research progress on the mechanism of action of hesperetin in cerebral ischemia: a narrative review
Research progress on the mechanism of action of hesperetin in cerebral ischemia: a narrative review Open
In this narrative review, Hesperidin exhibits antioxidant stress, anti-platelet aggregation, vasodilation, anti-atherosclerotic, anti-inflammatory, anti-apoptotic, hypolipidemic, anti-tumor, cardiovascular protection, and nitric oxide-rele…