Explanipedia

Trends in outpatient care utilization for patients with established atrial fibrillation before and after the Covid-19 pandemic: a nationwide analysis of claims data Open

Lanting Yang, Jingchuan Guo, Nimish Patel, Utibe R. Essien, Walid F. Gellad , et al. · 2025

Objective To evaluate trends in outpatient visits among Medicare beneficiaries with established AF before and after the pandemic and to investigate differences in outpatient care utilization patterns based on baseline utilization levels. R…

High-Throughput Safety Signal Detection for Sodium-Glucose Cotransporter-2 Inhibitors in Type 2 Diabetes Open

Yao An Lee, Jingchuan Guo · 2025

Objective To systematically identify potential safety signals associated with sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with type 2 diabetes (T2D) using a high-throughput target trial emulation pipeline applied to real…

Real-World Effectiveness and Safety of GLP-1 Receptor Agonists in Patients with Weight Recurrence After Bariatric Surgery Open

Rotana M. Radwan, Yao An Lee, Hao Dai, Yi Guo, Jiang Bian , et al. · 2025

Importance Weight recurrence occurs in nearly 20% of patients following metabolic and bariatric surgery (MBS) and can diminish long-term metabolic benefits. While glucagon-like peptide-1 receptor agonists and gastric inhibitory polypeptide…

GLP-1 Receptor Agonists and Acute Diabetes Complications in Adults with Type 1 Diabetes: A Target Trial Emulation Open

Hao Dai, Matthew R. Hayes, Jingchuan Guo · 2025

Background To evaluate the association between Glucagon-like peptide-1 receptor agonists (GLP-1RA) use and the risk of acute diabetes complications among adults with type 1 diabetes (T1D) who were eligible for anti-obesity medication (AOM)…

Evidence of cosmic-ray acceleration up to sub-PeV energies in the supernova remnant IC 443 Open

Z. Cao, Y.J Bi, W Bian, A.V Bukevich, Chang Cai , et al. · 2025

Supernova remnants (SNRs) have been considered as the primary contributors to cosmic rays (CRs) in our Galaxy. However, the maximum energy of particles that can be accelerated by shocks of SNRs is uncertain observationally and theoreticall…

Temporally Detailed Hypergraph Neural ODEs for Type 2 Diabetes Progression Modeling Open

Tingsong Xiao, Yao An Lee, Zelin Xu, Yupu Zhang, Zhen Liu , et al. · 2025

Disease progression modeling aims to characterize and predict how a patient's disease complications worsen over time based on longitudinal electronic health records (EHRs). Accurate modeling of disease progression, such as type 2 diabetes,…

All-Sky Search for Individual Primordial Black Hole Bursts with LHAASO Open

Z. Cao, F. Aharonian, Y. X. Bai, Y. W. Bao, D. Bastieri , et al. · 2025

Primordial black holes (PBHs) are hypothetical black holes with a wide range of masses that formed in the early Universe. As a result, they may play an important cosmological role and provide a unique probe of the early Universe. A PBH wit…

Neonatal outcomes among pregnant women with COVID-19: a systematic scoping review and meta-analysis Open

Yongqiu Li, Ying Lü, Huilin Tang, Eliot Spector, Xiaoxiao Wen , et al. · 2025

Predialysis Nephrology Care Disparities and Incident Vascular Access Among Hispanic Individuals Open

Sheena Pramod, Grant D. Scheiffele, Wenxi Huang, Chetan Parmar, Yi Guo , et al. · 2025

Importance Predialysis nephrology care is associated with the likelihood of having a mature, usable arteriovenous access for starting hemodialysis (ie, incident vascular access), a key care quality metric for patients with kidney failure. …

Assessing the Geographic Distribution of Community-Based Pharmacy Residency Programs in Areas of Health Care Need Open

Chardaé Whitner, Inas Mahdi, Aicha Ndiaye, Rasheed A. Adeyemi, WIlliam Wei-Han Chen , et al. · 2025

The expansion of Community-Based Pharmacy Residency programs in MUAs, P-HPSAs, and CDC SVIs could present a vital strategy to address health care disparities and improve access to pharmacist-led clinical services and health care.

External Exposome Factors and Adverse Heart Failure Outcomes in the OneFlorida+ Network: Retrospective Cohort Study Open

Wenxi Huang, Stephen E. Kimmel, Mustafa M. Ahmed, Steven M. Smith, Yao An Lee , et al. · 2025

Background Heart failure (HF) readmission rates vary across geographic regions in the United States, yet the impact of external exposome factors, such as contextual-level social determinants of health (SDoH), on adverse HF outcomes is not …

GLP-1 RA Use and Survival Among Older Adults With Cancer and Type 2 Diabetes Open

Rotana M. Radwan, Ying Lü, Hao Dai, Thomas J. George, Yi Guo , et al. · 2025

This cohort study evaluates whether older adults with type 2 diabetes and cancer have improved survival when taking glucagon-like peptide-1 receptor agonists (GLP-1RAs) compared with sodium-glucose cotransporter-2 inhibitors and dipeptidyl…

A fair machine learning model to predict flares of systemic lupus erythematosus Open

Yongqiu Li, Lixia Yao, Yao An Lee, Yu Huang, Peter A. Merkel , et al. · 2025

Objective Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that disproportionately affects women and racial/ethnic minority groups. Predicting disease flares is essential for improving patient outcomes, yet few studies in…

Clinical outcomes of pharmacological therapies for heart failure in Black vs. White populations: a meta-analysis of randomized controlled trials of heart failure treatment Open

Yujia Li, Huilin Tang, Wenxi Huang, Wei‐Han Chen, Shao‐Hsuan Chang , et al. · 2025

Objective To evaluate the effect of different pharmacological therapies for heart failure (HF) between the Black vs. White population. Method We included randomized controlled trials (RCT) of HF pharmacological therapies with explicit stra…

Heterogeneous treatment effects of GLP‐1RAs and SGLT2is on risk of Alzheimer's disease and related dementia in patients with type 2 diabetes: Insights from a real‐world target trial emulation Open

Huilin Tang, William T. Donahoo, Steven T. DeKosky, Yao An Lee, Pareeta Kotecha , et al. · 2025

INTRODUCTION This study assessed the heterogeneous treatment effects (HTEs) of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) on the risk of Alzheimer's disease and related deme…

First Identification and Precise Spectral Measurement of the Proton Component in the Cosmic-Ray `Knee' Open

The LHAASO Collaboration, F. Aharonian, Y. Bai, Y. W. Bao, D. Bastieri , et al. · 2025

We report the first high-purity identification of cosmic-ray (CR) protons and a precise measurement of their energy spectrum from 0.15 to 12 PeV using the Large High Altitude Air Shower Observatory (LHAASO). Abundant event statistics, comb…

Care coordination and patient safety outcome: a graph-based approach Open

Hongyu Chen, Yu Huang, Cheng Yin, Xingkang He, Ronald L. Ison , et al. · 2025

Predicting postoperative adverse events and managing the associated risk factors is crucial for patient safety. Care coordination, also known as provider team interactions, significantly impacts outcomes, yet few studies have explored this…

Development and Validation of An Electronic Health Record Based Algorithm for Patients with Long-term Opioid Therapy: A Cross-sectional Study (Preprint) Open

Shu Huang, Tianze Jiao, Jingchuan Guo, Jill A. Star, Jie Xu , et al. · 2025

Optimizing Strategy for Lung Cancer Screening: From Risk Prediction to Clinical Decision Support Open

Hao Dai, Yu Huang, Xing He, Tiancheng Zhou, Yuxi Liu , et al. · 2025

PURPOSE Low-dose computed tomography (LDCT) screening is effective in reducing lung cancer mortality by detecting the disease at earlier, more treatable stages. However, high false-positive rates and the associated risks of subsequent inva…

Identifying Alzheimer’s Disease Progression Subphenotypes via a Graph-based Framework using Electronic Health Records Open

Yu Huang, Jie Xu, Zhengkang Fan, Yu Hu, Xing He , et al. · 2025

A Natural Language Processing-Based Approach for Early Detection of Heart Failure Onset using Electronic Health Records Open

Yuxi Liu, Zusheng Tan, Zhenhao Zhang, Song Wang, Jingchuan Guo , et al. · 2025

Objectives This study set out to develop and validate a risk prediction tool for the early detection of heart failure (HF) onset using real-world electronic health records (EHRs). Background While existing HF risk assessment models have sh…

Telemedicine Utilization Trajectories and Sociodemographic Differences, 2019-2024 Open

Bingyu Zhang, Lu Li, Yiwen Lu, Jingchuan Guo, Jiang Bian , et al. · 2025

IMPORTANCE Telemedicine usage surged during the COVID-19 pandemic, shaping how patients access healthcare services. Its sustained role in post-pandemic healthcare may uncover long-term trends and variations in utilization. OBJECTIVE To cha…

Trends and Disparities in Newer GLP1 Receptor Agonist Initiation among Real-World Adult Patients Eligible for Obesity Treatment Open

Rotana M. Radwan, Yao An Lee, Pareeta Kotecha, Davene R. Wright, Inmaculada Hernández , et al. · 2025

Aims To characterize trends in the initiation of newer anti-obesity medications (AOMs) and determine factors associated with their use among obese/overweight populations. Materials and methods This retrospective study utilized electronic h…

Social Determinants of Healthy Aging: An Investigation using the All of Us Cohort Open

Wei‐Han Chen, Y.-H. Lee, Huilin Tang, Chenyu Li, Ying Lü , et al. · 2025

Introduction The increasing aging population raises significant concerns about the ability of individuals to age healthily, avoiding chronic diseases and maintaining cognitive and physical functions. However, the pathways through which SDO…

Advancing social determinants of health research and practice: Data, tools, and implementation Open

Chenyu Li, Jingchuan Guo, Jiang Bian, Michael J. Becich · 2025

Structural factors and their influence on the use of novel antidiabetic agents: Making the case for increased awareness and access to clinical pharmacy services Open

Olga M. Trejos Kweyete, D. R. Woods, Joahn Okoumba, Jingchuan Guo, John M. Allen · 2024

Type 2 diabetes (T2D) affects over 38 million Americans, leading to significant health complications and substantial healthcare costs. Novel antidiabetic medications, such as SGLT2 inhibitors and GLP‐1 receptor agonists, have shown promise…

A Scoping Review of Observational Research on Cannabis Use for Symptom Management in <span>HIV</span> and Cancer: Implications for Cannabis Nursing Open

Hwayoung Cho, Elena Kalina, J. T. Wu, Robert L. Cook, Ramzi G. Salloum , et al. · 2024

Background People with HIV have a higher risk of developing non‐AIDS‐defining cancers in older age, leading to a significant population living with two conditions, HIV and cancer. There is an increasing interest in cannabis use for symptom…

The most effective combination of pharmacological therapy for heart failure with reduced ejection fraction: a network meta-analysis of randomized controlled trials Open

Huilin Tang, Kimberly Germinal, Alexandra Milfort, Wei‐Han Chen, Shao‐Hsuan Chang , et al. · 2024

Real‐World Effectiveness of All‐Oral Direct‐Acting Antivirals in Patients With Hepatitis C Virus‐Related <span>HCC</span> Open

Shao‐Hsuan Chang, Roniel Cabrera, Jeong Heo, Chanhyun Park, Jingchuan Guo , et al. · 2024

The association between direct‐acting antiviral (DAA) treatment and hepatitis C virus (HCV)‐related hepatocellular carcinoma (HCC) is currently unclear. Hence, we aim to assess the association between DAA treatment and mortality rate among…

Social determinants of health and newer glucose-lowering drugs adoption among US Medicare beneficiaries with type 2 diabetes Open

Wei‐Han Chen, Yujia Li, Aokun Chen, John M. Allen, Yi Guo , et al. · 2024

We identified key contextual-level SDOH associated with real-world adoption of newer GLDs and explored their geographic variation through spatially explicit, data-driven analytical approaches. Identifying areas of strong association betwee…

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