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View article: Supplementary Methods from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Supplementary Methods from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Supplementary Methods
View article: Supplementary Tables S1-S6 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Supplementary Tables S1-S6 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Table S1. List of antibodies used and their technical information Table S2. The sequence of Real-time PCR primersTable S3. The sequence of shRNAs for silencing STAT3 Table S4. The sequence of ChromatinImmunoprecipitation (Ch-IP) PCRTable S…
View article: Coral dealbatus Crude Polysaccharide Attenuates Fat Accumulation and Intestinal Flora Disorders in Mice Fed with a High-Fat Diet
Coral dealbatus Crude Polysaccharide Attenuates Fat Accumulation and Intestinal Flora Disorders in Mice Fed with a High-Fat Diet Open
Obesity, a major risk factor for cardiometabolic diseases, arises from chronic energy imbalance and ectopic lipid deposition. This study investigated the anti-obesity potential of Coral dealbatus crude polysaccharides (CDP), a previously u…
View article: MRI-based radiomics for noninvasive prediction of T790M resistance mutation in lung cancer spinal metastases: an exploratory study
MRI-based radiomics for noninvasive prediction of T790M resistance mutation in lung cancer spinal metastases: an exploratory study Open
Background The T790M mutation is a significant mechanism of acquired resistance to EGFR-TKIs in non-small cell lung cancer (NSCLC). Its noninvasive detection in spinal metastases remains challenging due to tumour heterogeneity and limitati…
View article: Assessing the suitability of boiling in the boletus species: a multimodal analysis of texture, flavor, and volatile profiles
Assessing the suitability of boiling in the boletus species: a multimodal analysis of texture, flavor, and volatile profiles Open
Multi-dimensional characterization was conducted to assess post-boiling quality variations among five Boletus species, with the aim of identifying the most suitable variety for boiling. Texture profile analysis revealed that Suil…
View article: Fermented walnut milk alleviates high-fat-diet-induced obesity in mice via modulating gut microbiota and lipid metabolism
Fermented walnut milk alleviates high-fat-diet-induced obesity in mice via modulating gut microbiota and lipid metabolism Open
View article: Unveiling the potential of Rumex hanus diets on chicken meat quality: Insights from metabolomics and molecular dynamics approach
Unveiling the potential of Rumex hanus diets on chicken meat quality: Insights from metabolomics and molecular dynamics approach Open
View article: Process optimization and flavor characteristics of cream cheese fermented with avocado co-cultures
Process optimization and flavor characteristics of cream cheese fermented with avocado co-cultures Open
This study investigated the impact of avocado co-fermentation on the texture, microstructure, and flavor profile of cream cheese. Avocado puree served as an substrate for R704, yielding a viable cell count of 187.67 × 106 CFU/g …
View article: From waste to flavor enhancer: differential pressure explosion puffing modifies spent coffee grounds for microbial consortia-driven flavor synthesis in craft beer systems
From waste to flavor enhancer: differential pressure explosion puffing modifies spent coffee grounds for microbial consortia-driven flavor synthesis in craft beer systems Open
The high lignocellulosic encapsulation of spent coffee grounds (SCG) severely restricts their substrate accessibility and microbial responsiveness. This study elucidated the regulatory mechanism by which differential pressure explosion puf…
View article: Exploring the effects of Rumex hanus diets on the flavor and texture of roasted chicken: Insights from metabolomics and sensory analytical approaches
Exploring the effects of Rumex hanus diets on the flavor and texture of roasted chicken: Insights from metabolomics and sensory analytical approaches Open
View article: Exploring the effects of milk-enriched walnut soy sauce: Insights from GC-IMS and metagenomics approach to flavor and microbial shifts
Exploring the effects of milk-enriched walnut soy sauce: Insights from GC-IMS and metagenomics approach to flavor and microbial shifts Open
View article: Enhanced Fermentation of Pu-Erh Tea with Aspergillus niger: Quality and Microbial Community Analysis
Enhanced Fermentation of Pu-Erh Tea with Aspergillus niger: Quality and Microbial Community Analysis Open
Post-fermented Pu-erh tea (PFPT) is a microbial fermented tea characterized by unique sensory attributes and multiple health benefits. Aspergillus niger is the dominant fungus involved in the fermentation process and plays a significant ro…
View article: Audio-visual aesthetic teaching methods in college students’ vocal music teaching by deep learning
Audio-visual aesthetic teaching methods in college students’ vocal music teaching by deep learning Open
In recent times, characterized by the rapid advancement of science and technology, the educational system has continuously evolved. Within this modern educational landscape, Science, Technology, Engineering, Arts, and Mathematics (STEAM) e…
View article: Vegetation Biotic Factors Rather than Climate Factors Dominate Productivity Growth Across Climate Zones and Vegetation Types
Vegetation Biotic Factors Rather than Climate Factors Dominate Productivity Growth Across Climate Zones and Vegetation Types Open
View article: Thresholds of Heat Extremes Inducing Productivity Loss Over Arid Central Asia
Thresholds of Heat Extremes Inducing Productivity Loss Over Arid Central Asia Open
View article: Data from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Data from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Purpose:Pancreatic cancer is the worst prognosis among all human cancers, and novel effective treatments are urgently needed. Signal transducer and activator of transcription 3 (STAT3) has been demonstrated as a promising target for pancre…
View article: Supplementary Tables S1-S6 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Supplementary Tables S1-S6 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Table S1. List of antibodies used and their technical information Table S2. The sequence of Real-time PCR primersTable S3. The sequence of shRNAs for silencing STAT3 Table S4. The sequence of ChromatinImmunoprecipitation (Ch-IP) PCRTable S…
View article: Supplementary Methods from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Supplementary Methods from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Supplementary Methods
View article: Data from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Data from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Purpose:Pancreatic cancer is the worst prognosis among all human cancers, and novel effective treatments are urgently needed. Signal transducer and activator of transcription 3 (STAT3) has been demonstrated as a promising target for pancre…
View article: Supplementary Figures S1-S13 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Supplementary Figures S1-S13 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Fig. S1. Structure-based ligand discovery of STAT3 inhibitorsFig. S2. Surface plasmon resonance analysis of interactions between WB436B to STATfamily proteinsFig. S3. The biology evaluation of WB436B inactive analogue WB345Fig. S4. The mut…
View article: Supplementary Methods from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Supplementary Methods from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Supplementary Methods
View article: Supplementary Tables S1-S6 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Supplementary Tables S1-S6 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Table S1. List of antibodies used and their technical information Table S2. The sequence of Real-time PCR primersTable S3. The sequence of shRNAs for silencing STAT3 Table S4. The sequence of ChromatinImmunoprecipitation (Ch-IP) PCRTable S…
View article: Supplementary Figures S1-S13 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Supplementary Figures S1-S13 from Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Fig. S1. Structure-based ligand discovery of STAT3 inhibitorsFig. S2. Surface plasmon resonance analysis of interactions between WB436B to STATfamily proteinsFig. S3. The biology evaluation of WB436B inactive analogue WB345Fig. S4. The mut…
View article: Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer
Selectively Targeting STAT3 Using a Small Molecule Inhibitor is a Potential Therapeutic Strategy for Pancreatic Cancer Open
Purpose: Pancreatic cancer is the worst prognosis among all human cancers, and novel effective treatments are urgently needed. Signal transducer and activator of transcription 3 (STAT3) has been demonstrated as a promising target for pancr…
View article: Angiotensin-Converting Enzyme 2 SNPs as Common Genetic Loci and Optimal Early Identification Genetic Markers for COVID-19
Angiotensin-Converting Enzyme 2 SNPs as Common Genetic Loci and Optimal Early Identification Genetic Markers for COVID-19 Open
Background: Angiotensin-converting enzyme 2 (ACE2) is implicated as a host cell receptor that causes infection in the pathogenesis of coronavirus disease 2019 (COVID-19), and its genetic polymorphisms in the ACE2 gene may promote cardiovas…
View article: The Crosstalk Between Malignant Cells and Tumor-Promoting Immune Cells Relevant to Immunotherapy in Pancreatic Ductal Adenocarcinoma
The Crosstalk Between Malignant Cells and Tumor-Promoting Immune Cells Relevant to Immunotherapy in Pancreatic Ductal Adenocarcinoma Open
Background: Pancreatic ductal adenocarcinoma (PDAC) is dominated by an immunosuppressive microenvironment, which makes immune checkpoint blockade (ICB) often non-responsive. Understanding the mechanisms by which PDAC forms an immunosuppres…
View article: Screening of potential hub genes in pulmonary thromboembolism
Screening of potential hub genes in pulmonary thromboembolism Open
Pulmonary thromboembolism (PTE) is a fatal clinical syndrome that usually occurs in elderly individuals. The present study aimed to identify functional and key genes involved in the early diagnosis of PTE using bioinformatics analysis. The…
View article: Circular RNA-DPP4 serves an oncogenic role in prostate cancer progression through regulating miR-195/cyclin D1 axis
Circular RNA-DPP4 serves an oncogenic role in prostate cancer progression through regulating miR-195/cyclin D1 axis Open
Background Recently, more and more studies have highlighted the critical regulatory roles of circular RNAs (circRNAs), a class of non-coding RNAs, in the progression of many human cancers, including prostate cancer (PCa). circRNA microarra…
View article: Monitoring Coronavirus Disease 2019: A Review of Available Diagnostic Tools
Monitoring Coronavirus Disease 2019: A Review of Available Diagnostic Tools Open
Coronavirus disease 2019 (COVID-19) pneumonia is caused by the virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has rapidly become a global public health concern. As the new type of betacoronavirus , SARS-CoV-2 can sp…
View article: Regression of Castration-Resistant Prostate Cancer by a Novel Compound HG122
Regression of Castration-Resistant Prostate Cancer by a Novel Compound HG122 Open
Prostate cancer (PCa) is a common aggressive disease worldwide which usually progresses into incurable castration-resistant prostate cancer (CRPC) in most cases after 18–24 months treatment. Androgen receptor (AR) has been considered as a …