Jinghui Wang
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View article: Biomineralized Cu-Disulfiram nanoparticles Potentiate Colorectal cancer immunotherapy through synergistic cuproptosis and apoptosis
Biomineralized Cu-Disulfiram nanoparticles Potentiate Colorectal cancer immunotherapy through synergistic cuproptosis and apoptosis Open
The aberrant tumor microenvironment (TME) in colorectal cancer (CRC) significantly limits the efficacy of current immunotherapy regimes. To address this challenge, the albumin-based copper (Cu) and Cu ionophores disulfiram (DSF) co-loaded …
View article: Analysis of Spatiotemporal Features in Virtual Navigation Game Across Different Age Groups: Quantitative research (Preprint)
Analysis of Spatiotemporal Features in Virtual Navigation Game Across Different Age Groups: Quantitative research (Preprint) Open
BACKGROUND Virtual reality (VR) navigation games are increasingly employed to investigate human navigational behavior and cognitive performance under controlled spatial conditions. However, there is a lack of empirical research on how spa…
View article: The role of TgEfhc3 in Toxoplasma gondii biology and its prospects as a subunit vaccine
The role of TgEfhc3 in Toxoplasma gondii biology and its prospects as a subunit vaccine Open
Background Toxoplasmosis, caused by Toxoplasma gondii (T. gondii), poses a significant global health threat with no commercial vaccine available. The parasite's egress process, which bridges its intracellular replication cycles and is crit…
View article: Gradient Joule Heating Curing Performance of Steel-Fiber-Reinforced High-Performance Concrete in Severe Cold Environments: A Preliminary Attempt for Deep-Cold Concrete Construction
Gradient Joule Heating Curing Performance of Steel-Fiber-Reinforced High-Performance Concrete in Severe Cold Environments: A Preliminary Attempt for Deep-Cold Concrete Construction Open
Winter concrete construction in cold regions faces significant challenges due to extreme subzero temperatures, and the harsh environment presents new requirement for cement-based materials to resist this hostile external condition. To addr…
View article: A real-world based study for immunogenicity and safety for three immunization schedules of polio vaccine
A real-world based study for immunogenicity and safety for three immunization schedules of polio vaccine Open
View article: Adverse events following immunization surveillance on two types of enterovirus 71 vaccines: A real-world comparative study in China
Adverse events following immunization surveillance on two types of enterovirus 71 vaccines: A real-world comparative study in China Open
To comprehensively assess the safety and difference of two types of EV71 vaccines: EV71-Vero, produced using Vero cells and EV71-H2, using human diploid cells. Our research included children of the recommended age who voluntarily received …
View article: Improvements of Soft Magnetic Properties and Stress Resistance for Fe-Based Nanocrystalline Core by a Multi-Stage Annealing Before Tfa
Improvements of Soft Magnetic Properties and Stress Resistance for Fe-Based Nanocrystalline Core by a Multi-Stage Annealing Before Tfa Open
View article: Improvements of Soft Magnetic Properties and Stress Resistance for Fe-Based Nanocrystalline Cores by Setting a Multi-Stage Annealing Before Tfa
Improvements of Soft Magnetic Properties and Stress Resistance for Fe-Based Nanocrystalline Cores by Setting a Multi-Stage Annealing Before Tfa Open
View article: Surveillance for adverse events following immunization in Hebei Province, China, 2018-2020
Surveillance for adverse events following immunization in Hebei Province, China, 2018-2020 Open
The aim of this study was to analyze the incidence and characteristics of adverse events following immunization (AEFI) with post-licensure vaccines used in Hebei province from 2018 to 2020 and to evaluate the safety of vaccines. All inform…
View article: Molecular Complexity of Colorectal Cancer: Pathways, Biomarkers, and Therapeutic Strategies
Molecular Complexity of Colorectal Cancer: Pathways, Biomarkers, and Therapeutic Strategies Open
Colorectal cancer (CRC) is a diverse disease entity and a leading cause of cancer-related mortality worldwide. CRC results from the accumulation of multiple genetic and epigenetic alterations. This heterogeneity of CRC underscores the sign…
View article: The prognostic factors of clinical outcomes in non-small cell lung cancer patients receiving subsequent treatments after progression on initial immunotherapy
The prognostic factors of clinical outcomes in non-small cell lung cancer patients receiving subsequent treatments after progression on initial immunotherapy Open
PD-L1 positive expression, and longer PFS in initial immunotherapy would be good prognostic factors for NSCLC patients undergoing STAP on first immunotherapy. Besides, compared with original regimen, changing ICI would prolong PFS2 for NSC…
View article: Evaluating the dynamic psychological and behavioral changes of water-saving in public buildings under effective interventions
Evaluating the dynamic psychological and behavioral changes of water-saving in public buildings under effective interventions Open
This paper addresses the critical aspect of water conservation in public buildings within the context of sustainable urban water resources management. While conventional approaches rely on pricing controls and water-saving appliances, this…
View article: Inducing piezoelectricity in distorted rutile TiO <sub>2</sub> for enhanced tetracycline hydrochloride degradation through photopiezocatalysis
Inducing piezoelectricity in distorted rutile TiO <sub>2</sub> for enhanced tetracycline hydrochloride degradation through photopiezocatalysis Open
Various material design strategies have been developed to enhance photocatalytic performance of TiO2. However, no report is available on applications of the photopiezocatalysis strategy on TiO2 due to its lack of piezoelectricity. Here we …
View article: A novel detection method based on MIRA-CRISPR/Cas13a-LFD targeting the repeated DNA sequence of Trichomonas vaginalis
A novel detection method based on MIRA-CRISPR/Cas13a-LFD targeting the repeated DNA sequence of Trichomonas vaginalis Open
View article: Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5‘-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway
Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5‘-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway Open
Objective This study aimed to explore the expression and biological functions of SIRT3 in colorectal cancer cells (HCT-116), the impacts of sulforaphane on the ferroptosis of HCT-116 cells and the involvement of the SIRT3/AMPK/mTOR axis in…
View article: Assessing spatio-temporal characteristics and their driving factors of ecological vulnerability in the northwestern region of Liaoning Province (China)
Assessing spatio-temporal characteristics and their driving factors of ecological vulnerability in the northwestern region of Liaoning Province (China) Open
Evaluating the ecological vulnerability of the northwestern region of Liaoning Province, a typical ecologically vulnerable area in China, and exploring its inherent patterns help formulate effective measures for ecological protection and r…
View article: Insight into the Formation Mechanism of Oxidation Layer on the Amorphous Boron Nanocluster Surface
Insight into the Formation Mechanism of Oxidation Layer on the Amorphous Boron Nanocluster Surface Open
View article: A novel detection method based on MIRA-CRISPR/Cas13a-LFD targeting the repeated DNA sequence of Trichomonas vaginalis
A novel detection method based on MIRA-CRISPR/Cas13a-LFD targeting the repeated DNA sequence of Trichomonas vaginalis Open
Trichomonas vaginalis ( T. vaginalis ) is a protozoan parasite that is widely recognized as the most prevalent non-viral sexually transmitted infection (STI) worldwide. This infection is associated with various complications such as pelvic…
View article: Association of fine particulate matter constituents and ozone with immunotherapy outcomes among Non-small cell lung cancer patients
Association of fine particulate matter constituents and ozone with immunotherapy outcomes among Non-small cell lung cancer patients Open
BACKGROUND AND AIM: Short-term or long-term evidence for associations between pollutants and immunotherapy outcomes of non-small cell lung cancer (NSCLC) patients was extensively sparse. We aimed to comprehensively understand the impacts o…
View article: Design and Fabrication of Si-Based Double-Layer Cross Curved Microchannel
Design and Fabrication of Si-Based Double-Layer Cross Curved Microchannel Open
View article: Low Carbon Economic Dispatch Optimization of Regional Integrated Energy Systems Considering Heating Network and P2G
Low Carbon Economic Dispatch Optimization of Regional Integrated Energy Systems Considering Heating Network and P2G Open
Against a background of the energy internet and low-carbon electricity, regional integrated energy system (RIES) has become a key way to achieve sustainable energy development, leading to reduced operating costs and system carbon emissions…
View article: Neutron Spectroscopy Evidence for a Possible Magnetic-Field-Induced Gapless Quantum-Spin-Liquid Phase in a Kitaev Material α-RuCl<sub>3</sub>
Neutron Spectroscopy Evidence for a Possible Magnetic-Field-Induced Gapless Quantum-Spin-Liquid Phase in a Kitaev Material α-RuCl<sub>3</sub> Open
As one of the most promising Kitaev quantum-spin-liquid (QSL) candidates, α -RuCl 3 has received a great deal of attention. However, its ground state exhibits a long-range zigzag magnetic order, which defies the QSL phase. Nevertheless, th…
View article: Promotional effect of silica on the combustion of nano-sized aluminum powder in carbon dioxide
Promotional effect of silica on the combustion of nano-sized aluminum powder in carbon dioxide Open
This paper presents how the combustion performance of nano-sized aluminum (nAl) powder in carbon dioxide are affected by silica. The ignition and combustion performance of nAl powder with silica addition were studied by a high-temperature …
View article: Roles of the Narrow Electronic Band near the Fermi Level in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mn>1</mml:mn><mml:mi>T</mml:mi><mml:mtext>−</mml:mtext><mml:msub><mml:mrow><mml:mi>TaS</mml:mi></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>-Related Layered Materials
Roles of the Narrow Electronic Band near the Fermi Level in -Related Layered Materials Open
Here we use low-temperature scanning tunneling microscopy and spectroscopy to reveal the roles of the narrow electronic band in two 1T-TaS_{2}-related materials (bulk 1T-TaS_{2} and 4H_{b}-TaS_{2}). 4H_{b}-TaS_{2} is a superconducting comp…
View article: Status, causes and consequences of physicians’ self-perceived professional reputation damage in China: a cross-sectional survey
Status, causes and consequences of physicians’ self-perceived professional reputation damage in China: a cross-sectional survey Open
View article: Bi-Level Multi-Objective Optimal Design of Integrated Energy System Under Low-Carbon Background
Bi-Level Multi-Objective Optimal Design of Integrated Energy System Under Low-Carbon Background Open
The integrated energy system can realize the coupling and complementation of various energy sources such as cold, heat and electricity, and plays an important role in the consumption of renewable energy. This paper proposes a bi-level opti…
View article: A cross-sectional study of job burnout, psychological attachment, and the career calling of Chinese doctors
A cross-sectional study of job burnout, psychological attachment, and the career calling of Chinese doctors Open
Background The main objectives of this study were as follows: (1) evaluate the prevalence of burnout syndrome among doctors, (2) establish associations with demographic factors in China, and (3) examine the mediating role of psychological …
View article: A Cross-Sectional Study of Job Burnout, Psychological Attachment, and the Career Calling of Chinese Doctors
A Cross-Sectional Study of Job Burnout, Psychological Attachment, and the Career Calling of Chinese Doctors Open
Background: The main objectives of this study were as follows: (1) evaluate the prevalence of burnout syndrome among doctors, (2) establish associations with demographic factors in China, and (3) examine the mediating role of psychological…
View article: A Cross-Sectional Study of Job Burnout, Psychological Attachment, and the Career Calling of Chinese Doctors
A Cross-Sectional Study of Job Burnout, Psychological Attachment, and the Career Calling of Chinese Doctors Open
Background: The main objectives of this study were as follows: (1) evaluate the prevalence of burnout syndrome among doctors, (2) establish associations with demographic factors in China, and (3) examine the mediating role of psychological…
View article: A Cross-Sectional Study of Job Burnout, Psychological Attachment, and the Career Calling of Chinese Doctors
A Cross-Sectional Study of Job Burnout, Psychological Attachment, and the Career Calling of Chinese Doctors Open
Background: The main objectives of this study were as follows: (1) evaluate the prevalence of burnout syndrome among doctors, (2) establish associations with demographic factors in China, and (3) examine the mediating role of psychological…