Jianrong Lu
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View article: Intratumoral and peritumoral multiparametric MRI-based radiomics nomogram for preoperative risk stratification in patients with endometrial cancer
Intratumoral and peritumoral multiparametric MRI-based radiomics nomogram for preoperative risk stratification in patients with endometrial cancer Open
Introduction Achieving accurate preoperative risk stratification for endometrial cancer (EC) is challenging due to the need for histopathology to obtain the necessary parameters. This study aimed to establish and validate a multiparametric…
View article: Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion
Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion Open
Background: Epithelial-mesenchymal transition (EMT) is prevalent in human cancer and facilitates tumor metastasis and therapy resistance by enhancing cancer cell motility, invasiveness, survival, and immune evasion. However, the molecular …
View article: Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion
Epithelial-Mesenchymal Transition Activates YAP to Drive Malignant Progression and Immune Evasion Open
Epithelial-mesenchymal transition (EMT) is prevalent in human cancer, and facilitates tumor metastasis and therapy resistance by enhancing cancer cell motility, invasiveness, survival, and immune evasion. However, the molecular mechanisms …
View article: The Clinical Application Value of a Novel Chip in the Detection of Pathogens in Adult Pneumonia: A Multi-Centre Prospective Study in China
The Clinical Application Value of a Novel Chip in the Detection of Pathogens in Adult Pneumonia: A Multi-Centre Prospective Study in China Open
This study indicates that compared to CMT, this novel chip has significant advantages in detecting pathogens in pneumonia patients, especially in the elderly.
View article: FXa-mediated PAR-2 promotes the efficacy of immunotherapy for hepatocellular carcinoma through immune escape and anoikis resistance by inducing PD-L1 transcription
FXa-mediated PAR-2 promotes the efficacy of immunotherapy for hepatocellular carcinoma through immune escape and anoikis resistance by inducing PD-L1 transcription Open
Background The high metastasis rate is one of the main reasons for the poor prognosis of patients with hepatocellular carcinoma (HCC). Coagulation factor Xa (FXa) and its receptor proteinase-activated receptor-2 (PAR-2) proven to promote t…
View article: A folding motif formed with an expanded genetic alphabet
A folding motif formed with an expanded genetic alphabet Open
Adding synthetic nucleotides to DNA increases the linear information density of DNA molecules. Here we report that it also can increase the diversity of their three-dimensional folds. Specifically, an additional nucleotide (dZ, with a 5-ni…
View article: Functional Selection of Tau Oligomerization‐Inhibiting Aptamers
Functional Selection of Tau Oligomerization‐Inhibiting Aptamers Open
Pathological hyperphosphorylation and aggregation of microtubule‐associated Tau protein contribute to Alzheimer's Disease (AD) and other related tauopathies. Currently, no cure exists for Alzheimer's Disease. Aptamers offer significant pot…
View article: Toward a Team of AI-made Scientists for Scientific Discovery from Gene Expression Data
Toward a Team of AI-made Scientists for Scientific Discovery from Gene Expression Data Open
Machine learning has emerged as a powerful tool for scientific discovery, enabling researchers to extract meaningful insights from complex datasets. For instance, it has facilitated the identification of disease-predictive genes from gene …
View article: Supplementary Table 1 from Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance
Supplementary Table 1 from Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance Open
PDF file - 69K, Supplementary Table 1: Emerging metabolic targets and the inhibitors that have shown promise to overcome cancer cell resistance to therapeutics.
View article: Supplementary Table 1 from Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance
Supplementary Table 1 from Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance Open
PDF file - 69K, Supplementary Table 1: Emerging metabolic targets and the inhibitors that have shown promise to overcome cancer cell resistance to therapeutics.
View article: Data from Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance
Data from Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance Open
Cancer cells are markedly different from normal cells with regards to how their metabolic pathways are used to fuel cellular growth and survival. Two basic metabolites that exemplify these differences through increased uptake and altered m…
View article: Data from Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance
Data from Stalling the Engine of Resistance: Targeting Cancer Metabolism to Overcome Therapeutic Resistance Open
Cancer cells are markedly different from normal cells with regards to how their metabolic pathways are used to fuel cellular growth and survival. Two basic metabolites that exemplify these differences through increased uptake and altered m…
View article: Targeting HSF1 for cancer treatment: mechanisms and inhibitor development
Targeting HSF1 for cancer treatment: mechanisms and inhibitor development Open
Heat Shock Factor 1 (HSF1) is a master regulator of heat shock responsive signaling. In addition to playing critical roles in cellular heat shock response, emerging evidence suggests that HSF1 also regulates a non-heat shock responsive tra…
View article: MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer
MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer Open
The mammalian STE 20-like protein kinase 4 (MST4) gene is highly expressed in several cancer types, but little is known about the role of MST4 in breast cancer, and the function of MST4 during epithelial-mesenchymal transition (EMT) has no…
View article: MST4: a Potential Oncogene and Therapeutic Target in Breast Cancer
MST4: a Potential Oncogene and Therapeutic Target in Breast Cancer Open
The mammalian STE 20-like protein kinase 4 (MST4) gene is highly expressed in several cancer types, but little is known on the role of MST4 in breast cancer and the function of MST4 during epithelial-mesenchymal transition (EMT) has not be…
View article: A New Folding Motif Formed with an Expanded Genetic Alphabet
A New Folding Motif Formed with an Expanded Genetic Alphabet Open
Adding nucleotide pairs to a DNA alphabet not only increases the linear information density of DNA molecules, but also may increase the diversity of folds available to the molecular system. Reported here is an example of this. A single add…
View article: Epithelial–Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress
Epithelial–Mesenchymal Transition Suppresses AMPK and Sensitizes Cancer Cells to Pyroptosis under Energy Stress Open
Epithelial–mesenchymal transition (EMT) is implicated in tumor metastasis and therapeutic resistance. It remains a challenge to target cancer cells that have undergone EMT. The Snail family of key EMT-inducing transcription factors directl…
View article: FBXO11 deficiency in mice impairs lung development and aggravates cigarette smoke-induced airway fibrosis
FBXO11 deficiency in mice impairs lung development and aggravates cigarette smoke-induced airway fibrosis Open
Small airway fibrosis is a common pathology of chronic obstructive pulmonary disease (COPD) and contributes to airflow obstruction. However, the underlying fibrogenic mechanism is poorly understood. Epithelial-mesenchymal transition (EMT) …
View article: Renal Denervation Attenuates Adverse Remodeling and Intramyocardial Inflammation in Acute Myocardial Infarction With Ischemia–Reperfusion Injury
Renal Denervation Attenuates Adverse Remodeling and Intramyocardial Inflammation in Acute Myocardial Infarction With Ischemia–Reperfusion Injury Open
Background Inhibition of sympathetic activity and renin–angiotensin system with renal denervation (RDN) was proved to be effective in managing refractory hypertension, and improving left ventricular (LV) performance in chronic heart failur…
View article: Effect of naturally derived surgical hemostatic materials on the proliferation of A549 human lung adenocarcinoma cells
Effect of naturally derived surgical hemostatic materials on the proliferation of A549 human lung adenocarcinoma cells Open
Hemostatic materials are generally applied in surgical operations for cancer, but their effects on the growth and recurrence of tumors are unclear. Herein, three commonly used naturally derived hemostatic materials, gelatin sponge, Surgice…
View article: Anti‐inflammatory mechanisms and research progress of colchicine in atherosclerotic therapy
Anti‐inflammatory mechanisms and research progress of colchicine in atherosclerotic therapy Open
Inflammatory responses play a vital role in the onset and development of atherosclerosis, and throughout the entire process of the chronic disease. The inflammatory responses in atherosclerosis are mainly mediated by the NLRP3 inflammasome…
View article: Research on Design and Construction Technology of Large Span T-Truss Suspension Beam
Research on Design and Construction Technology of Large Span T-Truss Suspension Beam Open
Urban subway construction is often in the lower part of the city center road, and there are many municipal pipelines and pipelines in the lower part of the road. Because it involves the life of the surrounding residents, it is difficult to…
View article: Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation
Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation Open
Lung cancer with loss-of-function of the LKB1 tumor suppressor is a common aggressive subgroup with no effective therapies. LKB1 - deficiency induces constitutive activation of cAMP/CREB-mediated transcription by a family of three CREB-reg…
View article: The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma
The CRTC1-MAML2 fusion is the major oncogenic driver in mucoepidermoid carcinoma Open
No effective systemic treatment is available for patients with unresectable, recurrent, or metastatic mucoepidermoid carcinoma (MEC), the most common salivary gland malignancy. MEC is frequently associated with a t(11;19)(q14-21;p12-13) tr…
View article: Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma
Targeting Notch and EGFR signaling in human mucoepidermoid carcinoma Open
Mucoepidermoid carcinoma (MEC) is the most common type of salivary gland cancers and patients with advanced, metastatic, and recurrent MECs have limited therapeutic options and poor treatment outcomes. MEC is commonly associated with a chr…