Jennifer C. Hou
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View article: Exploring the psychological impact of long COVID: symptoms, mechanisms, and treatments
Exploring the psychological impact of long COVID: symptoms, mechanisms, and treatments Open
Long COVID (LC) refers to a multisystem condition that persists after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). In addition to physical sympt…
View article: RS-YOLO: A highly accurate real-time detection model for small-target pest
RS-YOLO: A highly accurate real-time detection model for small-target pest Open
View article: Mscmamba-Unet: A Lightweight Multi-Scale Mamba Network for Skin Lesion Segmentation
Mscmamba-Unet: A Lightweight Multi-Scale Mamba Network for Skin Lesion Segmentation Open
View article: Indication Finding: a novel use case for representation learning
Indication Finding: a novel use case for representation learning Open
Many therapies are effective in treating multiple diseases. We present an approach that leverages methods developed in natural language processing and real-world data to prioritize potential, new indications for a mechanism of action (MoA)…
View article: Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast
Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast Open
Many protein ion channels harness membrane potential to move ions in opposition to their chemical gradient. Deficiencies of such proteins cause several human diseases, including cystic fibrosis, Bartter Syndrome Type II, and proximal renal…
View article: Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear
Comparison of the Pharmacokinetic Properties of Triamcinolone and Dexamethasone for Local Therapy of the Inner Ear Open
Some forms of triamcinolone may provide alternate options for local therapy of the inner ear in addition to the steroids currently in use. We compared the perilymph pharmacokinetics of triamcinolone-acetonide, triamcinolone, and dexamethas…
View article: Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast
Mechanisms underlying polyene macrolide mediated rescue of growth in ion channel deficient yeast Open
Human diseases caused by missing or dysfunctional protein ion channels, known as channelopathies, affect several organs and systems of the body including that of the heart, lungs, kidneys, and nervous system. Channelopathies can result in …
View article: Dexamethasone and Dexamethasone Phosphate Entry into Perilymph Compared for Middle Ear Applications in Guinea Pigs
Dexamethasone and Dexamethasone Phosphate Entry into Perilymph Compared for Middle Ear Applications in Guinea Pigs Open
Dexamethasone phosphate is widely used for intratympanic therapy in humans. We assessed the pharmacokinetics of dexamethasone entry into perilymph when administered as a dexamethasone phosphate solution or as a micronized dexamethasone sus…
View article: Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel
Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel Open
Deficiencies of protein ion channels underlie many currently incurable human diseases. Robust networks of pumps and channels are usually responsible for the directional movement of specific ions in organisms ranging from microbes to humans…