Jing‐Jun Nie
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View article: Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration
Hydrogel Enhanced Organoid Multidirectional Differentiation via Yap/Tead4 Mechanotransduction for Accelerated Tissue Regeneration Open
The repair of multiple organs in motor systems remains a major clinical challenge that necessitates bioactive grafts with a multidirectional differentiation ability. Hydrogel-based organoids implants have emerged as pivotal tools and attra…
View article: Interfering with proton and electron transfer enables antibacterial starvation therapy
Interfering with proton and electron transfer enables antibacterial starvation therapy Open
Implant-associated infections are urgently addressed; however, existing materials are difficult to kill bacteria without damaging cells. Here, we propose an innovative concept of selective antibacterial starvation therapy based on interfer…
View article: Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping
Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping Open
Osteosarcoma is the most common malignant bone tumor without efficient management for improving 5-year event-free survival. Immunotherapy is also limited due to its highly immunosuppressive tumor microenvironment (TME). Pore-forming gasder…
View article: The research status and prospects of nanomaterials in wound healing: A scientometric study
The research status and prospects of nanomaterials in wound healing: A scientometric study Open
Nanotechnology and nanomaterials have swiftly influenced wound healing, propelling the development of wound-healing nanomaterials. Therefore, it’s crucial to gather essential information about prominent researches in this domain. Moreover,…
View article: Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy
Microgel-based carriers enhance skeletal stem cell reprogramming towards immunomodulatory phenotype in osteoarthritic therapy Open
Skeletal stem cells (SSC) have gained attentions as candidates for the treatment of osteoarthritis due to their osteochondrogenic capacity. However, the immunomodulatory properties of SSC, especially under delivery operations, have been la…
View article: Carboxypeptidase E is a prognostic biomarker co-expressed with osteoblastic genes in osteosarcoma
Carboxypeptidase E is a prognostic biomarker co-expressed with osteoblastic genes in osteosarcoma Open
Osteosarcoma (OS) is a rare primary malignant bone tumor in adolescents and children with a poor prognosis. The identification of prognostic genes lags far behind advancements in treatment. In this study, we identified differential genes u…
View article: Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma
Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma Open
miRNAs are important regulators of gene expression and play key roles in the development of cancer, including osteosarcoma. During the development of osteosarcoma, the expression of miR-22 is significantly downregulated, making miR-22 as a…
View article: Redox-Unlockable Nanoparticle-Based MST1 Delivery System to Attenuate Hepatic Steatosis via the AMPK/SREBP-1c Signaling Axis
Redox-Unlockable Nanoparticle-Based MST1 Delivery System to Attenuate Hepatic Steatosis via the AMPK/SREBP-1c Signaling Axis Open
To date, few effective treatments have been licensed for nonalcoholic fatty liver disease (NAFLD), which a kind of chronic liver disease. Mammalian sterile 20-like kinase 1 (MST1) is reported to be involved in the development of NAFLD. Thu…
View article: The Influence of Copper Content on the Elastic Modulus and Antibacterial Properties of Ti-13Nb-13Zr-xCu Alloy
The Influence of Copper Content on the Elastic Modulus and Antibacterial Properties of Ti-13Nb-13Zr-xCu Alloy Open
Device-related infection or inflammatory and stress shield are still the main problems faced by titanium alloy implants for long-term implantation application; therefore, it is of great significance to design an alloy with low elastic modu…
View article: Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications
Mechanical Stimulation on Mesenchymal Stem Cells and Surrounding Microenvironments in Bone Regeneration: Regulations and Applications Open
Treatment of bone defects remains a challenge in the clinic. Artificial bone grafts are the most promising alternative to autologous bone grafting. However, one of the limiting factors of artificial bone grafts is the limited means of regu…
View article: Analysis of Immune Gene Expression Subtypes Reveals Osteosarcoma Immune Heterogeneity
Analysis of Immune Gene Expression Subtypes Reveals Osteosarcoma Immune Heterogeneity Open
Background. Osteosarcoma (OS) patients have a poor response to immunotherapy due to the sheer complexity of the immune system and the nuances of the tumor-immune microenvironment. Methodology. To gain insights into the immune heterogeneity…
View article: Rhodium(I) Complex-Based Polymeric Nanomicelles in Water Exhibiting Coexistent Near-Infrared Phosphorescence Imaging and Anticancer Activity in Vivo
Rhodium(I) Complex-Based Polymeric Nanomicelles in Water Exhibiting Coexistent Near-Infrared Phosphorescence Imaging and Anticancer Activity in Vivo Open
Metal complexes that exhibit both near-infrared (NIR) phosphorescence imaging and chemotherapeutic activity would represent a novel class of anticancer drugs in clinical tumor treatment. In this work, a series of novel rodlike nanomicelles…
View article: Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function
Functional Nanocomplexes with Vascular Endothelial Growth Factor A/C Isoforms Improve Collateral Circulation and Cardiac Function Open
Protein‐based therapies are potential treatments for cancer, immunological, and cardiovascular diseases. However, effective delivery systems are needed because of their instability, immunogenicity, and so on. Crosslinked negatively charged…
View article: Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy
Oxidation‐Responsive Nanoassemblies for Light‐Enhanced Gene Therapy Open
Small 2019, 15, 1904017 In the originally published article, the author name “Zunjing Liu” was spelled incorrectly. The corrected author byline is presented here. The authors apologize for any inconvenience this may have caused.