Jing Shi
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View article: Association between intraoperative lactate levels and acute kidney injury after on-pump cardiac surgery: a retrospective cohort study across two centers
Association between intraoperative lactate levels and acute kidney injury after on-pump cardiac surgery: a retrospective cohort study across two centers Open
View article: Lysosome-like structures in the nucleolus mediate H2Aub degradation under glucose starvation
Lysosome-like structures in the nucleolus mediate H2Aub degradation under glucose starvation Open
Glucose starvation leads to the degradation of intracellular proteins to generate amino acids for energy production. However, it remains unclear which proteins undergo rapid degradation to supply amino acids as energy sources during glucos…
View article: E3 ubiquitin ligase MARCH5 positively regulates Japanese encephalitis virus infection by catalyzing the K27-linked polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon production
E3 ubiquitin ligase MARCH5 positively regulates Japanese encephalitis virus infection by catalyzing the K27-linked polyubiquitination of viral E protein and inhibiting MAVS-mediated type I interferon production Open
Membrane-associated RING-CH-type finger (MARCH) proteins, a class of E3 ubiquitin ligases, have been reported to be involved in the infection of multiple viruses and the regulation of type I interferon (IFN) production. However, the specif…
View article: Biocontrol Mechanism of Streptomyces Sp. Mepf0303 Against Sclerotium Delphinii Causing Dendrobium Officinale Southern Blight Revealed by Multi-Omics Analysis
Biocontrol Mechanism of Streptomyces Sp. Mepf0303 Against Sclerotium Delphinii Causing Dendrobium Officinale Southern Blight Revealed by Multi-Omics Analysis Open
View article: Calcium chloride connects potato greening and enzymatic browning through salicylic acid
Calcium chloride connects potato greening and enzymatic browning through salicylic acid Open
View article: Variations in how medical researchers report variables in risk scores or models to predict prognosis of patients after percutaneous coronary intervention: a retrospective analysis of published articles
Variations in how medical researchers report variables in risk scores or models to predict prognosis of patients after percutaneous coronary intervention: a retrospective analysis of published articles Open
Background: The use of risk variables in prognostic risk scores/models to evaluate patients after percutaneous coronary intervention (PCI) has been a controversial topic in medical literature. We therefore analyzed variations in risk score…
View article: Distribution characteristics of potentially toxic metal(loid)s in the soil and in tea plant (Camellia sinensis)
Distribution characteristics of potentially toxic metal(loid)s in the soil and in tea plant (Camellia sinensis) Open
View article: Serum and Fecal Metabolite Profiles Linking With Gut Microbiome in Triple-Negative Breast Cancer Patients
Serum and Fecal Metabolite Profiles Linking With Gut Microbiome in Triple-Negative Breast Cancer Patients Open
Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by poor prognosis due to the absence of effective targeted therapies. Emerging evidence indicates that the gut microbiota and its metabolites play…
View article: Integrative metabolome and transcriptome analyses reveal the differences in flavonoid and terpenoid synthesis between Glycyrrhiza uralensis (licorice) leaves and roots
Integrative metabolome and transcriptome analyses reveal the differences in flavonoid and terpenoid synthesis between Glycyrrhiza uralensis (licorice) leaves and roots Open
View article: Transcriptional deciphering of the metabolic pathways associated with the bioactive ingredients of wolfberry species with different quality characteristics
Transcriptional deciphering of the metabolic pathways associated with the bioactive ingredients of wolfberry species with different quality characteristics Open
View article: The Impact of ESBLs-Positive Escherichia coli’s Resistance to Cefepime and Its Guidance for Clinical Treatment
The Impact of ESBLs-Positive Escherichia coli’s Resistance to Cefepime and Its Guidance for Clinical Treatment Open
ESBL-positive E. coli induces an increase in the MIC value of FEP, leading to an increase in FEP resistance. The inoculation effect also causes a significant increase in the MPC value of FEP, especially the increase in selection ind…
View article: Integrated QTL Mapping, Meta-Analysis, and RNA-Sequencing Reveal Candidate Genes for Maize Deep-Sowing Tolerance
Integrated QTL Mapping, Meta-Analysis, and RNA-Sequencing Reveal Candidate Genes for Maize Deep-Sowing Tolerance Open
Synergetic elongation of mesocotyl and coleoptile are crucial in governing maize seedlings emergence, especially for the maize sown in deep soil. Studying the genomic regions controlling maize deep-sowing tolerance would aid the developmen…
View article: Association of intraoperative hyperglycemia with postoperative composite infection after cardiac surgery with cardiopulmonary bypass: A retrospective cohort study
Association of intraoperative hyperglycemia with postoperative composite infection after cardiac surgery with cardiopulmonary bypass: A retrospective cohort study Open
Background The association between intraoperative hyperglycemia (IH) and postoperative infections in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) is inadequately studied. Methods A total of 3,428 patients who under…
View article: RplI interacts with 5’ UTR of exsA to repress its translation and type III secretion system in Pseudomonas aeruginosa
RplI interacts with 5’ UTR of exsA to repress its translation and type III secretion system in Pseudomonas aeruginosa Open
Pseudomonas aeruginosa is an important opportunistic pathogen capable of causing variety of infections in humans. The type III secretion system (T3SS) is a critical virulence determinant of P . aeruginosa in the host infections. Expression…
View article: 24-epibrassinolide confers tolerance against deep-seeding stress in <i>Zea mays</i> L. coleoptile development by phytohormones signaling transduction and their interaction network
24-epibrassinolide confers tolerance against deep-seeding stress in <i>Zea mays</i> L. coleoptile development by phytohormones signaling transduction and their interaction network Open
Coleoptile/mesocotyl elongation influence seedling emergence and establishment, is major causes of maize deep-seeding tolerance (DST). Detailed analyses on molecular basis underlying their elongation mediated by brassinosteroid under deep-…
View article: Free Wanderer Powder regulates AMPA receptor homeostasis in chronic restraint stress-induced rat model of depression with liver-depression and spleen-deficiency syndrome
Free Wanderer Powder regulates AMPA receptor homeostasis in chronic restraint stress-induced rat model of depression with liver-depression and spleen-deficiency syndrome Open
Free Wanderer Powder (FWP) is a classic formula for depression with digestive dysfunctions, i.e., liver-depression and spleen-deficiency syndrome (LDSDS) in Chinese Medicine. But its protective mechanism has not been fully clarified. Here …
View article: MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation
MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation Open
Enveloped viruses express three classes of fusion proteins that are required for their entry into host cells via mediating virus and cell membrane fusion. Class I fusion proteins are produced from influenza viruses, retroviruses, Ebola vir…
View article: Pleural Fluid GSDMD&nbsp;is a Novel Biomarker for the Early Differential Diagnosis of Pleural Effusion
Pleural Fluid GSDMD is a Novel Biomarker for the Early Differential Diagnosis of Pleural Effusion Open
Introduction: To accurate differential diagnosis of pleural effusion (PE) is still a big challenge. Gasdermin D (GSDMD), controlling pyroptosis in cells, has multiple physiological functions. The diagnostic role of GSDMD in PE remains unkn…
View article: Development and validation of an electronic frailty index using routine electronic health records: an observational study of 49,226 elderly inpatients from a general hospital in China
Development and validation of an electronic frailty index using routine electronic health records: an observational study of 49,226 elderly inpatients from a general hospital in China Open
Background Frailty assessment based on routine electronic health records (EHR) may be a good alternative to time-consuming frailty scales. This study mainly aimed to develop and validate an electronic frailty index (eFI) using routine EHR …
View article: MARCH8 Restricts Ebola Virus Replication by Blocking the Viral Glycoprotein Processing and Glycosylation
MARCH8 Restricts Ebola Virus Replication by Blocking the Viral Glycoprotein Processing and Glycosylation Open
Ebola virus (EBOV) glycoprotein (GP) is a class I fusion protein whose maturation is dependent on furin-mediated processing. EBOV-GP is heavily glycosylated, with glycans constituting ~50% of its molecular mass. Compared with 15 N-l…
View article: PvrA is a novel regulator that contributes to Pseudomonas aeruginosa pathogenesis by controlling bacterial utilization of long chain fatty acids
PvrA is a novel regulator that contributes to Pseudomonas aeruginosa pathogenesis by controlling bacterial utilization of long chain fatty acids Open
During infection of a host, Pseudomonas aeruginosa orchestrates global gene expression to adapt to the host environment and counter the immune attacks. P. aeruginosa harbours hundreds of regulatory genes that play essential roles in contro…
View article: Comparative transcriptome analysis of anthocyanin synthesis in black and pink peanut
Comparative transcriptome analysis of anthocyanin synthesis in black and pink peanut Open
In recent years, black testa peanut (Arachis hypogaea L.) has been favored because of its nutritional value and health function. To explore the genetic basis of peanut testa color, high-throughput sequencing technology was used to s…
View article: CD4 Expression and Env Conformation Are Critical for HIV-1 Restriction by SERINC5
CD4 Expression and Env Conformation Are Critical for HIV-1 Restriction by SERINC5 Open
Restriction factors provide the first line of defense against retrovirus infection by posing several blocks to the viral replication cycle. SERINC5 is a novel restriction factor that strongly blocks HIV-1 entry, although it is counteracted…
View article: Identification of gene-phenotype connectivity associated with flavanone naringenin by functional network analysis
Identification of gene-phenotype connectivity associated with flavanone naringenin by functional network analysis Open
Naringenin, extracted from grapefruits and citrus fruits, is a bioactive flavonoid with antioxidative, anti-inflammatory, antifibrogenic, and anticancer properties. In the past two decades, the growth of publications of naringenin in PubMe…
View article: Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus
Induced Resistance Mechanism of Novel Curcumin Analogs Bearing a Quinazoline Moiety to Plant Virus Open
Plant immune activators can protect crops from plant virus pathogens by activating intrinsic immune mechanisms in plants and are widely used in agricultural production. In our previous work, we found that curcumin analogs exhibit excellent…
View article: Murine Leukemia Virus Glycosylated Gag Reduces Murine SERINC5 Protein Expression at Steady-State Levels via the Endosome/Lysosome Pathway to Counteract SERINC5 Antiretroviral Activity
Murine Leukemia Virus Glycosylated Gag Reduces Murine SERINC5 Protein Expression at Steady-State Levels via the Endosome/Lysosome Pathway to Counteract SERINC5 Antiretroviral Activity Open
MLV glycoGag not only enhances MLV replication but also increases HIV-1 infectivity similarly as Nef. Recent studies have discovered that both glycoGag and Nef antagonize a novel host restriction factor Ser5 and promote viral replication. …
View article: HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa
HigB Reciprocally Controls Biofilm Formation and the Expression of Type III Secretion System Genes through Influencing the Intracellular c-di-GMP Level in Pseudomonas aeruginosa Open
Toxin-antitoxin (TA) systems play important roles in bacteria persister formation. Increasing evidence demonstrate the roles of TA systems in regulating virulence factors in pathogenic bacteria. The toxin HigB in Pseudomonas aeruginosa con…
View article: The spectrogram data of quinazoline derivatives containing a dithioacetal moiety
The spectrogram data of quinazoline derivatives containing a dithioacetal moiety Open
View article: Carbapenem-Resistant E. cloacae in Southwest China: Molecular Analysis of Resistance and Risk Factors for Infections Caused by NDM-1-Producers
Carbapenem-Resistant E. cloacae in Southwest China: Molecular Analysis of Resistance and Risk Factors for Infections Caused by NDM-1-Producers Open
Carbapenem-resistant Enterobacteriaceae (CRE) has been considered a serious global threat, but carbapenem resistance remains relatively uncommon in E. cloacae, especially in China. The aim of this study was to characterize ca…
View article: Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery
Enhanced differentiation of human pluripotent stem cells into cardiomyocytes by bacteria-mediated transcription factors delivery Open
Virus-mediated expression of defined transcription factor (TF) genes can effectively induce cellular reprogramming. However, sustained expression of the TFs often hinders pluripotent stem cell (PSC) differentiation into specific cell types…