Jingmeng Chen
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View article: Activation of GSDME by all- <i>trans</i> -retinal increases sensitivity to photoreceptor ferroptosis
Activation of GSDME by all- <i>trans</i> -retinal increases sensitivity to photoreceptor ferroptosis Open
Impaired clearance of all-trans-retinal (atRAL) due to visual cycle dysfunction contributes to photoreceptor atrophy, a key pathological hallmark of Stargardt disease type 1 (STGD1) and dry age-related macular degeneration (AMD). Prior stu…
View article: Ferrostatin-1, a ferroptosis inhibitor, mitigates all-trans-retinal-induced retinal pigment epithelium degeneration in mice
Ferrostatin-1, a ferroptosis inhibitor, mitigates all-trans-retinal-induced retinal pigment epithelium degeneration in mice Open
Ferroptosis plays a critical role in RPE damage by atRAL. Inhibition of ferroptosis by Fer-1 may enhance RPE cell survival and prevent subsequent photoreceptor degeneration in STGD1 and dAMD.
View article: Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium
Exposure of A2E to blue light promotes ferroptosis in the retinal pigment epithelium Open
Background Age-dependent accumulation of lipofuscin in the retinal pigment epithelium (RPE) is closely related to the etiology of autosomal recessive Stargardt’s disease (STGD1) and dry age-related macular degeneration (AMD). N -retinylide…
View article: Circular RNA Expression and Regulation Profiling in Testicular Tissues of Immature and Mature Wandong Cattle (Bos taurus)
Circular RNA Expression and Regulation Profiling in Testicular Tissues of Immature and Mature Wandong Cattle (Bos taurus) Open
Wandong cattle are an autochthonous Chinese breed used extensively for beef production. The breed tolerates extreme weather conditions and raw feed and is resistant to tick-borne diseases. However, the genetic basis of testis development a…
View article: Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance
Ferroptosis drives photoreceptor degeneration in mice with defects in all-trans-retinal clearance Open
The death of photoreceptor cells in dry age-related macular degeneration (AMD) and autosomal recessive Stargardt disease (STGD1) is closely associated with disruption in all-trans-retinal (atRAL) clearance in neural retina. In this study, …
View article: Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-<i>trans</i> Retinal
Retinal Pigment Epithelium Cell Death Is Associated With NLRP3 Inflammasome Activation by All-<i>trans</i> Retinal Open
Aberrant build-up of atRAL promotes the death of RPE cells via NLRP3 inflammasome activation.
View article: Aberrant Buildup of All- <i>Trans</i> -Retinal Dimer, a Nonpyridinium Bisretinoid Lipofuscin Fluorophore, Contributes to the Degeneration of the Retinal Pigment Epithelium
Aberrant Buildup of All- <i>Trans</i> -Retinal Dimer, a Nonpyridinium Bisretinoid Lipofuscin Fluorophore, Contributes to the Degeneration of the Retinal Pigment Epithelium Open
These findings suggest that atRAL dimer that accumulates beyond a critical level, facilitates age-dependent RPE degeneration.