Jingmin Gu
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View article: Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis
Hepatocyte necroptosis is associated with liver damage in dairy cows with ketosis Open
Dairy cows with ketosis frequently exhibit impaired liver function and inflammation. Necroptosis, a form of programmed cell death associated with cellular lysis, releases damage-associated molecular patterns (DAMP) into injured tissues, th…
View article: Therapeutic efficacy of LysGH15 against necrotising pneumonia caused by Staphylococcus aureus in a rabbit model
Therapeutic efficacy of LysGH15 against necrotising pneumonia caused by Staphylococcus aureus in a rabbit model Open
Introduction Staphylococcus aureus ( S. aureus ) is one of the most important zoonotic pathogens and can be transmitted to humans through the meat diet routes, causing necrotising pneumonia. Methods This study investigated the therapeutic …
View article: Detection of Staphylococcus aureus via IgY-based immunomagnetic separation and a phage lysin LysGH15-based colloidal gold immunochromatographic assay
Detection of Staphylococcus aureus via IgY-based immunomagnetic separation and a phage lysin LysGH15-based colloidal gold immunochromatographic assay Open
IMBs-GICA can rapidly and sensitively detect for S. aureus, demonstrating the potential utility of this developed method in the field of testing.
View article: A Novel Phage Lysin Lys19 Can Serve as Potential Biocontrol Agent Against Clostridium Perfringens and Streptococcus Suis
A Novel Phage Lysin Lys19 Can Serve as Potential Biocontrol Agent Against Clostridium Perfringens and Streptococcus Suis Open
View article: Characterization of the Phage ΦK64 Depolymerase S2-4 and Its Therapeutic Effect Against K1 Serotype Klebsiella pneumoniae
Characterization of the Phage ΦK64 Depolymerase S2-4 and Its Therapeutic Effect Against K1 Serotype Klebsiella pneumoniae Open
View article: A novel phage putative depolymerase, Depo16, has specific activity against K1 capsular-type <i>Klebsiella pneumoniae</i>
A novel phage putative depolymerase, Depo16, has specific activity against K1 capsular-type <i>Klebsiella pneumoniae</i> Open
Klebsiella pneumoniae , especially hypervirulent K. pneumoniae (hvKP), is a common opportunistic pathogen that often causes hospital- and community-acquired infections. Capsular polysaccharide (CPS) is an important virulence factor of K. p…
View article: Development and application of an indirect ELISA and nested PCR for the epidemiological analysis of Klebsiella pneumoniae among pigs in China
Development and application of an indirect ELISA and nested PCR for the epidemiological analysis of Klebsiella pneumoniae among pigs in China Open
Introduction Klebsiella pneumoniae ( K. pneumoniae ) is an important opportunistic and zoonotic pathogen which is associated with many diseases in humans and animals. However, the pathogenicity of K. pneumoniae has been neglected and the p…
View article: Aerococcus viridans Phage Lysin AVPL Had Lytic Activity against Streptococcus suis in a Mouse Bacteremia Model
Aerococcus viridans Phage Lysin AVPL Had Lytic Activity against Streptococcus suis in a Mouse Bacteremia Model Open
Streptococcus suis (S. suis) is a swine pathogen that can cause sepsis, meningitis, endocarditis, and other infectious diseases; it is also a zoonotic pathogen that has caused a global surge in fatal human infections. The widespread preval…
View article: [PD-1 inhibitor in chronic active Epstein-Barr virus infection: a report of six cases and literature review].
[PD-1 inhibitor in chronic active Epstein-Barr virus infection: a report of six cases and literature review]. Open
View article: The Pig Intestinal Phageome is an Important Reservoir and Transfer Vector for Virulence Genes
The Pig Intestinal Phageome is an Important Reservoir and Transfer Vector for Virulence Genes Open
View article: Programmed Death of Microglia in Alzheimer's Disease: Autophagy, Ferroptosis, and Pyroptosis
Programmed Death of Microglia in Alzheimer's Disease: Autophagy, Ferroptosis, and Pyroptosis Open
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline, amyloid-β (Aβ) plaques and the formation of neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau. Increasing evidence ha…
View article: Recent advances on the regulation of bacterial biofilm formation by herbal medicines
Recent advances on the regulation of bacterial biofilm formation by herbal medicines Open
Biofilm formation is a fundamental part of life cycles of bacteria which affects various aspects of bacterial-host interactions including the development of drug resistance and chronic infections. In clinical settings, biofilm-related infe…
View article: The Combination of Phages and Faecal Microbiota Transplantation Can Effectively Treat Mouse Colitis Caused by Salmonella enterica Serovar Typhimurium
The Combination of Phages and Faecal Microbiota Transplantation Can Effectively Treat Mouse Colitis Caused by Salmonella enterica Serovar Typhimurium Open
Salmonella enterica serovar Typhimurium ( S. Typhimurium) is one of the common causes of human colitis. In the present study, two lytic phages vB_SenS-EnJE1 and vB_SenS-EnJE6 were isolated and the therapeutic effect of the combination of p…
View article: Oral vaccination with recombinant Lactobacillus casei expressing Aha1 fused with CTB as an adjuvant against Aeromonas veronii in common carp (Cyprinus carpio)
Oral vaccination with recombinant Lactobacillus casei expressing Aha1 fused with CTB as an adjuvant against Aeromonas veronii in common carp (Cyprinus carpio) Open
Aeromonas veronii (A. veronii) is a pathogenic that can infect human, animal and aquatic organisms, in which poses a huge threat to the health of many aquatic organisms such as Cyprinus carpio . In this study, Lactobacillus casei (L. casei…
View article: The Bacteriophage vB_CbrM_HP1 Protects Crucian Carp Against Citrobacter braakii Infection
The Bacteriophage vB_CbrM_HP1 Protects Crucian Carp Against Citrobacter braakii Infection Open
Citrobacter braakii is an opportunistic pathogen that induces aquatic infections in fish and turtles. In this study, a bacteriophage that infects C. braakii , named vB_CbrM_HP1, was isolated from sewage. This phage belongs to Myoviridae fa…
View article: Review of: "Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion"
Review of: "Multiple phage resistance systems inhibit infection via SIR2-dependent NAD+ depletion" Open
Review of: "Multiple phage resistance
View article: Editorial: The Application of Phages Against Infectious Diseases
Editorial: The Application of Phages Against Infectious Diseases Open
EDITORIAL article Front. Cell. Infect. Microbiol., 20 December 2021 | https://doi.org/10.3389/fcimb.2021.815984
View article: RETRACTED: vB-ApyS-JF1, the First Trueperella pyogenes Phage, Shows Potential as an Alternative Treatment Strategy for Trueperella pyogenes Infections
RETRACTED: vB-ApyS-JF1, the First Trueperella pyogenes Phage, Shows Potential as an Alternative Treatment Strategy for Trueperella pyogenes Infections Open
Trueperella pyogenes ( T. pyogenes ) is an important opportunistic animal pathogen that causes huge economic losses to the animal husbandry industry. The emergence of bacterial resistance and the unsatisfactory effect of the vaccine have p…
View article: Combination Therapy of Phage vB_KpnM_P-KP2 and Gentamicin Combats Acute Pneumonia Caused by K47 Serotype Klebsiella pneumoniae
Combination Therapy of Phage vB_KpnM_P-KP2 and Gentamicin Combats Acute Pneumonia Caused by K47 Serotype Klebsiella pneumoniae Open
Klebsiella pneumoniae ( K. pneumoniae ) is an important nosocomial and community acquired opportunistic pathogen which causes various infections. The emergence of multi-drug resistant (MDR) K. pneumoniae and carbapenem-resistant hypervirul…
View article: Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity
Streptococcus suis serotype 2 enolase interaction with host brain microvascular endothelial cells and RPSA-induced apoptosis lead to loss of BBB integrity Open
Host proteins interacting with pathogens are receiving more attention as potential therapeutic targets in molecular medicine. Streptococcus suis serotype 2 (SS2) is an important cause of meningitis in both humans and pigs worldwide. SS2 En…
View article: Pre-optimized phage therapy on secondary <i>Acinetobacter baumannii</i> infection in four critical COVID-19 patients
Pre-optimized phage therapy on secondary <i>Acinetobacter baumannii</i> infection in four critical COVID-19 patients Open
Phage therapy is recognized as a promising alternative to antibiotics in treating pulmonary bacterial infections, however, its use has not been reported for treating secondary bacterial infections during virus pandemics such as coronavirus…
View article: HIGH RATE OF ESBL- PRODUCING ESCHERICHIA COLI FROM RETAIL-CHICKEN CARRYING BLACTX-M GENE ON PLASMIDS MAINLY CARRYING FREPB REPLICON
HIGH RATE OF ESBL- PRODUCING ESCHERICHIA COLI FROM RETAIL-CHICKEN CARRYING BLACTX-M GENE ON PLASMIDS MAINLY CARRYING FREPB REPLICON Open
Antimicrobial resistance is increasingly reported worldwide, however, there is scarcity of data from Pakistan. Particularly, data from food-producing animals and their products is totally lacking. Here, we report on the ESBL-genotypes, int…
View article: Long-Term Results of Concurrent Chemoradiotherapy Combined With Anti-EGFR Monoclonal Antibody Prior to Surgery in Locally Advanced Cervical Cancer: A Single Institute Prospective Study
Long-Term Results of Concurrent Chemoradiotherapy Combined With Anti-EGFR Monoclonal Antibody Prior to Surgery in Locally Advanced Cervical Cancer: A Single Institute Prospective Study Open
View article: A Frameshift Mutation in wcaJ Associated with Phage Resistance in Klebsiella pneumoniae
A Frameshift Mutation in wcaJ Associated with Phage Resistance in Klebsiella pneumoniae Open
Phage therapy is a potential and promising avenue for controlling the emergence and spread of multidrug-resistant (MDR) Klebsiella pneumoniae, however, the rapid development of anti-phage resistance has been identified as an obstacle to th…
View article: The Yersinia Phage X1 Administered Orally Efficiently Protects a Murine Chronic Enteritis Model Against Yersinia enterocolitica Infection
The Yersinia Phage X1 Administered Orally Efficiently Protects a Murine Chronic Enteritis Model Against Yersinia enterocolitica Infection Open
Yersinia enterocolitica is generally considered an important food-borne pathogen worldwide, especially in the European Union. A lytic Yersinia phage X1 (Viruses; dsDNA viruses, no RNA stage; Caudovirales; and Myoviridae) was isolate…
View article: Overexpression of AmpC Promotes Bacteriophage Lysis of Ampicillin-Resistant Escherichia coli
Overexpression of AmpC Promotes Bacteriophage Lysis of Ampicillin-Resistant Escherichia coli Open
Infections caused by antibiotic-resistant Escherichia coli are a threat to human and animal health globally. Phage therapy has made great progress for the treatment of drug-resistant infections, but it is still unclear whether E.…
View article: Characterization of Klebsiella pneumoniae ST11 Isolates and Their Interactions with Lytic Phages
Characterization of Klebsiella pneumoniae ST11 Isolates and Their Interactions with Lytic Phages Open
The bacterial pathogen Klebsiella pneumoniae causes urinary tract infections in immunocompromised patients. Generally, the overuse of antibiotics contributes to the potential development and the spread of antibiotic resistance. In fact, ce…
View article: Three Capsular Polysaccharide Synthesis-Related Glucosyltransferases, GT-1, GT-2 and WcaJ, Are Associated With Virulence and Phage Sensitivity of Klebsiella pneumoniae
Three Capsular Polysaccharide Synthesis-Related Glucosyltransferases, GT-1, GT-2 and WcaJ, Are Associated With Virulence and Phage Sensitivity of Klebsiella pneumoniae Open
Klebsiella pneumoniae (K. pneumoniae) spp. are important nosocomial and community-acquired opportunistic pathogens, which cause various infections. We observed that K. pneumoniae strain K7 abruptly mutates to rough-typ…
View article: The Characteristics and Genome Analysis of vB_AviM_AVP, the First Phage Infecting Aerococcus viridans
The Characteristics and Genome Analysis of vB_AviM_AVP, the First Phage Infecting Aerococcus viridans Open
Aerococcus viridans is an opportunistic pathogen that is clinically associated with various human and animal diseases. In this study, the first identified A. viridans phage, vB_AviM_AVP (abbreviated as AVP), was isolated and studied. AVP b…
View article: Phage-Derived Lysins as Therapeutic Agents Against Multidrug-Resistant <i>Enterococcus Faecalis</i>
Phage-Derived Lysins as Therapeutic Agents Against Multidrug-Resistant <i>Enterococcus Faecalis</i> Open