Jianfeng Lin
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View article: Genetic insights into drug targets for alzheimer’s disease: integrative multi-omics analysis
Genetic insights into drug targets for alzheimer’s disease: integrative multi-omics analysis Open
This study established a comprehensive AD target atlas, revealing mechanism-anchored targets that were validated across multiomics analyses and a clinically actionable framework integrating efficacy, biology, and safety profiling. Overall,…
View article: Study on the Durability of Graphene Oxide Concrete Composite Under Chloride and Sulfate Environments
Study on the Durability of Graphene Oxide Concrete Composite Under Chloride and Sulfate Environments Open
In order to study the durability of graphene oxide concrete composite in chloride and sulfate environments, graphene oxide concrete composite specimens were immersed in a mixed solution of 5% sodium sulfate and sodium chloride. After dry–w…
View article: Infinite connected components of the space of symplectic forms on ruled surfaces
Infinite connected components of the space of symplectic forms on ruled surfaces Open
We provide an infinite family of diffeomorphic symplectic forms on ruled surfaces, which are pairwise non-isotopic. This answers a uniqueness question regarding symplectic structures up to isotopy on closed symplectic four-manifolds.
View article: A Single-center Retrospective Study of Laparoscopic-Assisted Megarectosigmoid Resection with Anal Reconstruction: Long-term Functional Outcomes and Prognostic Factors
A Single-center Retrospective Study of Laparoscopic-Assisted Megarectosigmoid Resection with Anal Reconstruction: Long-term Functional Outcomes and Prognostic Factors Open
Background Megarectosigmoid (MRS), a complication following anorectal malformation (ARM) repair, impairs pediatric quality of life. Current treatments lack consensus due to variable efficacy. Objective To evaluate the long-term outcome of …
View article: Identifying potential drug targets for sepsis-related adult respiratory distress syndrome through comprehensive genetic analysis and druggability assessment
Identifying potential drug targets for sepsis-related adult respiratory distress syndrome through comprehensive genetic analysis and druggability assessment Open
Through an extensive analysis, we identified potential drug targets for sepsis-related ARDS. Additional research is imperative to substantiate our discoveries and to pave the way for the development of novel pharmaceuticals aimed at these …
View article: Lifestyle factors associated with being overweight and obesity in children and adolescents: a cross-sectional study in Zhejiang, China
Lifestyle factors associated with being overweight and obesity in children and adolescents: a cross-sectional study in Zhejiang, China Open
Background The prevalence of overweight and obesity among children and adolescents aged 7 to 17 in China is increasingly concerning. Additionally, there is a notable phenomenon where height does not correspond with weight. This study aimed…
View article: Multiomics provides insights into dynamic changes of aromatic profile during flue-curing process in tobacco (Nicotiana tabacum L.) leaves
Multiomics provides insights into dynamic changes of aromatic profile during flue-curing process in tobacco (Nicotiana tabacum L.) leaves Open
Tobacco ( Nicotiana tabacum L.) is a globally crop due to its distinctive flavor and economic value. In this study, we systematically analyzed the dynamic changes in volatile substances, broad-spectrum metabolites, enzymes, and biochemical…
View article: Dax invariants, light bulbs, and isotopies of symplectic structures
Dax invariants, light bulbs, and isotopies of symplectic structures Open
This paper proves the following two main results. First, we classify the isotopy classes of embeddings of $Σ$ in $Σ\times S^2$ that are geometrically dual to $\{\mbox{pt}\}\times S^2$, where $Σ$ is a closed oriented surface with a positive…
View article: On the mapping class groups of 4-manifolds with 1-handles
On the mapping class groups of 4-manifolds with 1-handles Open
We develop a framework that generalizes Budney-Gabai's $W_3$ invariant on $π_0\textrm{Diff}(S^1\times D^3,\partial)$ to 4-manifolds with 1-handles. As applications, we show that if $M=(S^1\times D^3)\natural \hat M$ where $\hat M$ either h…
View article: Geospatial large language model trained with a simulated environment for generating tool-use chains autonomously
Geospatial large language model trained with a simulated environment for generating tool-use chains autonomously Open
Solving geospatial tasks generally requires multiple geospatial tools and steps, i.e., tool-use chains. Automating the geospatial task solving process can effectively enhance the efficiency of GIS users. Traditionally, researchers tend to …
View article: Outpatient coordination reform improves the sustainability of China's Urban Employee Basic Medical Insurance Fund
Outpatient coordination reform improves the sustainability of China's Urban Employee Basic Medical Insurance Fund Open
This study aims to examine the impact of outpatient coordination reform (OCR) on the sustainability of the Urban Employee Basic Medical Insurance (UEBMI) pooling fund. Using an employee medical insurance pooling fund model, we found that, …
View article: The monodromy diffeomorphism of weighted singularities and Seiberg--Witten theory
The monodromy diffeomorphism of weighted singularities and Seiberg--Witten theory Open
We prove that the monodromy diffeomorphism of a complex 2-dimensional isolated hypersurface singularity of weighted-homogeneous type has infinite order in the smooth mapping class group of the Milnor fiber, provided the singularity is not …
View article: On four-dimensional Dehn twists and Milnor fibrations
On four-dimensional Dehn twists and Milnor fibrations Open
We study the monodromy diffeomorphism of Milnor fibrations of isolated complex surface singularities, by computing the family Seiberg--Witten invariant of Seifert-fibered Dehn twists using recent advances in monopole Floer homology. More p…
View article: Configuration space integrals and formal smooth structures
Configuration space integrals and formal smooth structures Open
Watanabe disproved the 4-dimensional Smale conjecture by constructing topologically trivial $D^{4}$-bundles over spheres and showing that they are smoothly nontrivial using configuration space integrals. In this paper, we define a new vers…
View article: Isotopy of the Dehn twist on K3 # K3 after asingle stabilization
Isotopy of the Dehn twist on K3 # K3 after asingle stabilization Open
Isotopy of the Dehn twist on K 3 # K 3 after a single stabilization
View article: Identification of potential drug targets for varicose veins: a Mendelian randomization analysis
Identification of potential drug targets for varicose veins: a Mendelian randomization analysis Open
Introduction Varicose veins are a common chronic disease that creates a significant economic burden on the healthcare system. Current treatment options, including pharmacological treatments, are not always effective, and there is a need fo…
View article: Unfolded Seiberg–Witten Floer spectra, II: Relative invariants and the gluing theorem
Unfolded Seiberg–Witten Floer spectra, II: Relative invariants and the gluing theorem Open
We use the construction of unfolded Seiberg-Witten Floer spectra of general\n3-manifolds defined in our previous paper to extend the notion of relative\nBauer-Furuta invariants to general 4-manifolds with boundary. One of the main\npurpose…
View article: Designing bike-friendly cities: Interactive effects of built environment factors on bike-sharing
Designing bike-friendly cities: Interactive effects of built environment factors on bike-sharing Open
Designing bike-friendly cities could promote health and mitigate climate change. Most studies of the association between the built environment and cycling used the "5Ds" framework and linear modeling. However, the built environment exerts …
View article: Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis
Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis Open
Multiple sclerosis is a complex autoimmune disease, and several therapies for multiple sclerosis have been developed and widely used. However, existing medications for multiple sclerosis were far from satisfactory due to their failure to s…
View article: Homological instability for moduli spaces of smooth 4-manifolds
Homological instability for moduli spaces of smooth 4-manifolds Open
We prove that homological stability fails for the moduli space of any simply-connected closed smooth 4-manifold in any degree of homology, unlike what happens in all dimensions $\neq 4$. We detect also the homological discrepancy between v…
View article: Severe community-acquired pneumonia caused by <i>Chlamydia psittaci</i> genotype E/B strain circulating among geese in Lishui city, Zhejiang province, China
Severe community-acquired pneumonia caused by <i>Chlamydia psittaci</i> genotype E/B strain circulating among geese in Lishui city, Zhejiang province, China Open
Between November 2021 and January 2022, four patients of community-acquired pneumonia were admitted to the hospitals in Lishui city, Zhejiang province, China. Their main clinical manifestations were fever and dry cough as well as radiograp…
View article: The Family Seiberg-Witten Invariant and nonsymplectic loops of diffeomorphisms
The Family Seiberg-Witten Invariant and nonsymplectic loops of diffeomorphisms Open
By extending a result of Kronheimer-Mrowka to the family setting, we prove a gluing formula for the family Seiberg-Witten invariant. This formula allows one to compute the invariant for a smooth family of 4-manifolds by cutting it open alo…
View article: Comparison of the profiles of patients defined by age-adapted and fixed threshold CKD criteria: a nationwide, cross-sectional study
Comparison of the profiles of patients defined by age-adapted and fixed threshold CKD criteria: a nationwide, cross-sectional study Open
Background Kidney function declines naturally with advancing age. Therefore an age-adapted estimated glomerular filtration rate (eGFR) threshold has been proposed instead of the fixed threshold for CKD definition. This study aims to descri…
View article: Association of cardiovascular risk factors and lifestyle behaviors with aortic aneurysm: A Mendelian randomization study
Association of cardiovascular risk factors and lifestyle behaviors with aortic aneurysm: A Mendelian randomization study Open
Objective: To examine the causality between hypertension, diabetes, other cardiovascular risk factors, lifestyle behaviors, and the aortic aneurysm among patients of European ancestry. Methods: We performed two-sample Mendelian randomizati…
View article: Integrated bioinformatics analysis reveals significant genes associated with cryptorchidism (CO)
Integrated bioinformatics analysis reveals significant genes associated with cryptorchidism (CO) Open
Objective: we performed a comprehensive bioinformatics analysis to identify potential genes and signaling pathways associated with cryptorchidism. Materials and Methods: This study aimed to identify genes significantly associated with cryp…
View article: Research Letter: Genetically determined blood pressure traits are associated with increased risk of aortic dissection: a Mendelian randomization study
Research Letter: Genetically determined blood pressure traits are associated with increased risk of aortic dissection: a Mendelian randomization study Open
Objective To identify blood pressure traits influencing aortic dissection susceptibility using Mendelian randomization (MR). Methods Summary statistics of AD genome-wide association studies (GWAS) was obtained from FinnGen R5 release, whic…