Explanipedia

Ethnic and functional differentiation of copy number polymorphisms in Tunisian and HapMap population unveils insights on genome organizational plasticity Open

Lilia Romdhane, S. Kefi, Nessrine Mezzi, Najla Abassi, Haifa Jmel , et al. · 2024

GTN Enhances Antitumor Effects of Doxorubicin in TNBC by Targeting the Immunosuppressive Activity of PMN-MDSC Open

Nesrine Mabrouk, Cindy Racoeur, Jingxuan Shan, Aurélie Massot, S Ghione , et al. · 2023

(1) Background: Immunosuppression is a key barrier to effective anti-cancer therapies, particularly in triple-negative breast cancer (TNBC), an aggressive and difficult to treat form of breast cancer. We investigated here whether the combi…

Supplementary Methods, Figures 1 - 8, Table 1 from TNRC9 Downregulates BRCA1 Expression and Promotes Breast Cancer Aggressiveness Open

Jingxuan Shan, Shoba P. DSouza, Sasha Bakhru, Eman K. Al‐Azwani, Maria Libera Ascierto , et al. · 2023

PDF file - 655K, Supplementary Figure 1. TNRC9 promoted cell proliferation in MDA-MB-231 breast cancer cells. Supplementary Figure 2. shRNA-mediated knockdown of TNRC9. Supplementary Figure 3. H&E staining of tumors (10�Magnification) from…

Supplementary Methods, Figures 1 - 8, Table 1 from TNRC9 Downregulates BRCA1 Expression and Promotes Breast Cancer Aggressiveness Open

Jingxuan Shan, Shoba P. DSouza, Sasha Bakhru, Eman K. Al‐Azwani, Maria Libera Ascierto , et al. · 2023

PDF file - 655K, Supplementary Figure 1. TNRC9 promoted cell proliferation in MDA-MB-231 breast cancer cells. Supplementary Figure 2. shRNA-mediated knockdown of TNRC9. Supplementary Figure 3. H&E staining of tumors (10�Magnification) from…

Data from TNRC9 Downregulates BRCA1 Expression and Promotes Breast Cancer Aggressiveness Open

Jingxuan Shan, Shoba P. DSouza, Sasha Bakhru, Eman K. Al‐Azwani, Maria Libera Ascierto , et al. · 2023

Although the linkage between germline mutations of BRCA1 and hereditary breast/ovarian cancers is well established, recent evidence suggests that altered expression of wild-type BRCA1 might contribute to the sporadic forms of breast…

Data from TNRC9 Downregulates BRCA1 Expression and Promotes Breast Cancer Aggressiveness Open

Jingxuan Shan, Shoba P. DSouza, Sasha Bakhru, Eman K. Al‐Azwani, Maria Libera Ascierto , et al. · 2023

Although the linkage between germline mutations of BRCA1 and hereditary breast/ovarian cancers is well established, recent evidence suggests that altered expression of wild-type BRCA1 might contribute to the sporadic forms of breast…

Wearable Artificial Intelligence for Assessing Physical Activity in High School Children Open

Arfan Ahmed, Sarah Aziz, Uvais Qidwai, Faisal Farooq, Jingxuan Shan , et al. · 2022

Eighty one percent of adolescents aged 11–17 years are inadequately physically active worldwide. Physical activity (PA) recommendations for high school children have not been studied previously in schools in the Qatar region. The objective…

MIIP functions as a novel ligand for ITGB3 to inhibit angiogenesis and tumorigenesis of triple-negative breast cancer Open

Yujing Gao, Yujie Fang, Yongli Huang, Rui Ma, Xixi Chen , et al. · 2022

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study Open

Jingxuan Shan, André Mégarbané, Aziz Chouchane, Deepak Karthik, Ramzi Temanni , et al. · 2022

Background and Aims: Porto‐sinusoidal vascular disorder (PSVD) is a group of liver vascular diseases featuring lesions encompassing the portal venules and sinusoids unaccompanied by cirrhosis, irrespective of the presence/absence of portal…

Protein Kinase Inhibitor-Mediated Immunoprophylactic and Immunotherapeutic Control of Colon Cancer Open

S Ghione, Cindy Racoeur, Nesrine Mabrouk, Jingxuan Shan, Emma Groetz , et al. · 2022

Immunotherapy has allowed major advances in oncology in the past years, in particular with the development of immune checkpoint inhibitors, but the clinical benefits are still limited, particularly in colorectal cancer (CRC). Our scientifi…

Dromedary camels as a natural source of neutralizing nanobodies against SARS-CoV-2 Open

Lotfi Chouchane, Jean‐Charles Grivel, Elmoubasher Farag, Igor Pavlovski, Selma Maacha , et al. · 2021

The development of prophylactic and therapeutic agents for coronavirus disease 2019 (COVID-19) is a current global health priority. Here, we investigated the presence of cross-neutralizing antibodies against severe acute respiratory syndro…

A map of copy number variations in the Tunisian population: a valuable tool for medical genomics in North Africa Open

Lilia Romdhane, Nessrine Mezzi, Hamza Dallali, Olfa Messaoud, Jingxuan Shan , et al. · 2021

Precision medicine in the era of artificial intelligence: implications in chronic disease management Open

Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre, Sabri Boughorbel, Jingxuan Shan , et al. · 2020

Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to health and leading to diminished life expectancy. A dysregulated metabolism induces the secretion of several molecules which in turn trigger …

A Report on a Family with TMTC3-Related Syndrome and Review Open

Sayeeda Hana, Deepak Karthik, Jingxuan Shan, Stephany El‐Hayek, Lotfi Chouchane , et al. · 2020

Recessive mutations in the TMTC3 gene have been reported in thirteen patients to date exhibiting development delay, intellectual disability (ID), seizures, and muscular hypotonia, accompanied occasionally by neuronal migration defects expr…

Genome sequencing unveils mutational landscape of the familial Mediterranean fever: Potential implications of IL33/ST2 signalling Open

Meenakshi Umar, André Mégarbané, Jingxuan Shan, Najeeb Syed, Éliane Chouery , et al. · 2020

Familial Mediterranean fever (FMF) is the most common auto‐inflammatory disease. It is transmitted as autosomal recessive trait with mutations in MEditerranean FeVer ( MEFV) gene. Despite a typical clinical expression, many patients have e…

STXBP6, reciprocally regulated with autophagy, reduces triple negative breast cancer aggressiveness Open

Govinda Lenka, Jingxuan Shan, Najeeb Halabi, Sirin W. J. Abuaqel, Neha Goswami , et al. · 2020

Background Although autophagy plays a dual role in suppressing or promoting certain cancers, the nature of its involvement in breast cancers remains unclear. Here, we investigated the function of STXBP6, a protein regulating the autophagy‐…

Genetic Variation in CCL5 Signaling Genes and Triple Negative Breast Cancer: Susceptibility and Prognosis Implications Open

Jingxuan Shan, Aziz Chouchane, Younes Mokrab, Mohamad Saad, Salha Boujassoum , et al. · 2019

Triple-negative breast cancer (TNBC) accounts for ~15-20% of breast cancer (BC) and has a higher rate of early relapse and mortality compared to other subtypes. The Chemokine (C-C motif) ligand 5 (CCL5) and its signaling pathway have been …

Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancer Open

Jingxuan Shan, Mariam Al-Muftah, Moza Khalifa Alkowari, Sirin W. J. Abuaqel, Khalid Al‐Rumaihi , et al. · 2019

Prostate cancer (PC) castration resistance has been linked to the differentiation of PC luminal cells into hormone-refractory neuroendocrine (NE) cells. However, the molecular mechanisms controlling the emergence of lethal NE prostate canc…

A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci Open

Yosr Hamdi, Mariem Ben Rekaya, Jingxuan Shan, Majdi Nagara, Olfa Messaoud , et al. · 2018

Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations Open

Haifa Jmel, Lilia Romdhane, Yosra Ben Halima, Meriem Hechmi, Chokri Naouali , et al. · 2018

Genetic variation is an important determinant affecting either drug response or susceptibility to adverse drug reactions. Several studies have highlighted the importance of ethnicity in influencing drug response variability that should be …

Prostate cancer small non-coding RNA transcriptome in Arabs Open

Jingxuan Shan, Khalid Al‐Rumaihi, Karim Chouchane, Issam Al‐Bozom, Danny Rabah , et al. · 2017

These miRNAs, newly associated with prostate cancer, may represent not only markers for the increased risk of PCa in Arabs, but may also reflect the clinical and pathological diversity as well as the ethno-specific heterogeneity of prostat…

Precision medicine in breast cancer: reality or utopia? Open

Ali Bettaı̈eb, Catherine Paul, Stéphanie Plenchette, Jingxuan Shan, Lotfi Chouchane , et al. · 2017

MNS, Duffy, and Kell blood groups among the Uygur population of Xinjiang, China Open

Ging-Yau Lin, Xianglin L. Du, Jingxuan Shan, Yuxin Zhang, Y. Q. Zhang , et al. · 2017

Human blood groups are a significant resource for patients, leading to a fierce international competition in the screening of rare blood groups. Some rare blood group screening programs have been implemented in western countries and Japan,…

MOESM2 of Prostate cancer small non-coding RNA transcriptome in Arabs Open

Jingxuan Shan, Khalid Al‐Rumaihi, Karim Chouchane, Issam Al‐Bozom, Danny Rabah , et al. · 2017

Additional file 2: Table S4. miRNA reads summary.

MOESM3 of Prostate cancer small non-coding RNA transcriptome in Arabs Open

Jingxuan Shan, Khalid Al‐Rumaihi, Karim Chouchane, Issam Al‐Bozom, Danny Rabah , et al. · 2017

Additional file 3. miRNA expression comparison in each pair of PCa samples.

MOESM4 of Prostate cancer small non-coding RNA transcriptome in Arabs Open

Jingxuan Shan, Khalid Al‐Rumaihi, Karim Chouchane, Issam Al‐Bozom, Danny Rabah , et al. · 2017

Additional file 4. miRNA editing summary.

Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment Open

Pu Li, Jingxuan Shan, Xue-Hua Chen, Di Zhang, Li-Ping Su , et al. · 2015

Tumor initiation and growth depend on its microenvironment in which cancer-associated fibroblasts (CAFs) in tumor stroma play an important role. Prostaglandin E2 (PGE2) and interleukin (IL)-6 signal pathways are involved in the crosstalk b…

Cigarette smoke mediates epigenetic repression of miR-217 during esophageal adenocarcinogenesis Open

Xi Shi, Suzanne Inchauste, Hongbo Guo, Jingxuan Shan, Ziyang Xiao , et al. · 2015

Jingxuan Shan YOU? Author Swipe