Jingyi Dang
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View article: Unveiling the ESR1 dysfunction orchestrates the link per- and polyfluoroalkyl substances exposure to osteoarthritis: Insights from multi-scale evidence
Unveiling the ESR1 dysfunction orchestrates the link per- and polyfluoroalkyl substances exposure to osteoarthritis: Insights from multi-scale evidence Open
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants commonly involved in multiple health risks. Epidemiological studies have confirmed a direct connection between PFAS exposure(including PFOA and PFOS) with t…
View article: Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling
Decoding Endoplasmic Reticulum Stress on Chondrocyte Driving Osteoarthritis Development through Integrating Single-Cell and Transcriptomic Profiling Open
Background: Endoplasmic reticulum stress (ERS) as a potent disease regulator has been proven to be engaged in the pathogenesis and progression of numerous disorders. Osteoarthritis (OA) is a widespread degenerative disease of the joints wi…
View article: Gradient hydroxyapatite nanoparticles with spatial distribution facilitate the healing of tendon-to-bone interface
Gradient hydroxyapatite nanoparticles with spatial distribution facilitate the healing of tendon-to-bone interface Open
Tendon-to-bone interface (TBI) injuries have become increasingly common due to the growing competition in sports. Electrohydrodynamic (EHD) 3D printing is a promising strategy for controllably fabricating biomimetic micro/nanoscale archite…
View article: Downregulation of salusins alleviates hypertrophic cardiomyopathy via attenuating oxidative stress and autophagy
Downregulation of salusins alleviates hypertrophic cardiomyopathy via attenuating oxidative stress and autophagy Open
Introduction Salusins, which are translated from the alternatively spliced mRNA of torsin family 2 member A (TOR2A), play a vital role in regulation of various cardiovascular diseases. However, it remains unclear precisely regarding their …
View article: Calcium phosphate coating enhances osteointegration of melt electrowritten scaffold by regulating macrophage polarization
Calcium phosphate coating enhances osteointegration of melt electrowritten scaffold by regulating macrophage polarization Open
The osteoimmune microenvironment induced by implants plays a significant role in bone regeneration. It is essential to efficiently and timely switch the macrophage phenotype from M1 to M2 for optimal bone healing. This study examined the i…
View article: Melt electrospinning writing PCL scaffolds after alkaline modification with outstanding cytocompatibility and osteoinduction
Melt electrospinning writing PCL scaffolds after alkaline modification with outstanding cytocompatibility and osteoinduction Open
Melt electrospinning writing (MEW) is a promising three-dimensional (3D) printing technology that enables the creation of scaffolds with highly ordered microfibers. Polycaprolactone (PCL) is an ideal material for MEW scaffold fabrication d…
View article: Effect and mechanism of circHMGA2 on ferroptosis and pyroptosis in myocardial ischemia-reperfusion model CircHMGA2 exacerbates MI/R injury
Effect and mechanism of circHMGA2 on ferroptosis and pyroptosis in myocardial ischemia-reperfusion model CircHMGA2 exacerbates MI/R injury Open
Myocardial ischemia-reperfusion (MI/R) injury is a common and serious complication following reperfusion treatment for myocardial infarction (MI). Increasing evidence has verified the crucial role of circular RNAs (circRNAs) in the MI/R in…
View article: Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma
Characterization of myeloid signature genes for predicting prognosis and immune landscape in Ewing sarcoma Open
Myeloid cells as a highly heterogeneous subpopulation of the tumor microenvironment (TME) are intimately associated with tumor development. Ewing sarcoma (EWS) is characterized by abundant myeloid cell infiltration in the TME. However, the…
View article: Effect of electrohydrodynamic printing scaffold with different spacing on chondrocyte dedifferentiation
Effect of electrohydrodynamic printing scaffold with different spacing on chondrocyte dedifferentiation Open
3D printed scaffolds with 200 µm spacing can inhibit chondrocyte dedifferentiation, providing a basis for the future study of 3D printed scaffolds as an effective method for chondrocyte expansion.
View article: Unfolded Protein Response–Related Signature Associates With the Immune Microenvironment and Prognostic Prediction in Osteosarcoma
Unfolded Protein Response–Related Signature Associates With the Immune Microenvironment and Prognostic Prediction in Osteosarcoma Open
Background: Osteosarcoma is a highly malignant bone tumor commonly occurring in adolescents with a poor 5-year survival rate. The unfolded protein response (UPR) can alleviate the accumulation of misfolded proteins to maintain homeostasis …
View article: [Biomechanical analysis and effectiveness evaluation of zone <b>Ⅰ</b>+<b>Ⅱ</b>+<b>Ⅲ</b> reconstruction of hemipelvis with rod-screw prosthesis].
[Biomechanical analysis and effectiveness evaluation of zone <b>Ⅰ</b>+<b>Ⅱ</b>+<b>Ⅲ</b> reconstruction of hemipelvis with rod-screw prosthesis]. Open
The stress and deformation distribution of the reconstructed pelvis are basically the same as normal pelvis. The rod-screw prosthesis is an effective reconstruction method for pelvic malignant tumors.
View article: Comparison between trabectedin and doxorubicin in soft-tissue sarcomas-reply letter
Comparison between trabectedin and doxorubicin in soft-tissue sarcomas-reply letter Open
We thank for the comments from Wu et al. (1) on our research (2), comparison between trabectedin and doxorubicin in soft-tissue sarcomas.Reviewer Wu et al. said that in Table 1, we reported that 80 patients were included, which was inconsi…
View article: Clinical application of 3D-printed patient-specific guide plate combined with computer navigation in acetabular reconstruction following resection of periacetabular tumors
Clinical application of 3D-printed patient-specific guide plate combined with computer navigation in acetabular reconstruction following resection of periacetabular tumors Open
PSG + CN has potential advantages in improving the accuracy and safety of acetabular positioning and reconstruction.
View article: Comparison between trabectedin and doxorubicin in soft-tissue sarcomas: a systematic review and meta-analysis
Comparison between trabectedin and doxorubicin in soft-tissue sarcomas: a systematic review and meta-analysis Open
Our research showed that STS patients who received trabectedin had better clinical effects and a longer survival time than those who received doxorubicin.
View article: Investigating the protective effect of tanshinone IIA against chondrocyte dedifferentiation: a combined molecular biology and network pharmacology approach
Investigating the protective effect of tanshinone IIA against chondrocyte dedifferentiation: a combined molecular biology and network pharmacology approach Open
This study revealed a systematic network pharmacology approach and provided a basis for the future study of TIIA as an effective treatment for cartilage regeneration. Moreover, in vitro and in vivo results confirmed the protective effects …