Jingying Sun
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View article: Role of Autophagy Induced by Pmel17 in the Pathogenesis of Vitiligo
Role of Autophagy Induced by Pmel17 in the Pathogenesis of Vitiligo Open
The findings demonstrate that downregulation of Pmel17 contributes to the pathogenesis of vitiligo by inducing autophagy and inhibiting melanin synthesis, through the suppression of the PI3K-AKT-mTOR signaling pathway. These results provid…
View article: The reduced DLG5 promotes doxorubicin resistance in breast cancer cells MCF-7 through regulating autophagy
The reduced DLG5 promotes doxorubicin resistance in breast cancer cells MCF-7 through regulating autophagy Open
Breast cancer is among the most prevalent malignant tumors in women globally, with adriamycin (ADM) demonstrating considerable efficacy as a first-line chemotherapeutic agent. The problem of adriamycin resistance significantly impairs its …
View article: Research progress of animal models of antigen-induced autoimmune diseases
Research progress of animal models of antigen-induced autoimmune diseases Open
Autoimmune diseases (AID) are chronic debilitating diseases characterized by excessive or prolonged autoimmune responses, which lead to the destruction of normal tissue structures and consequent clinical symptoms. AID poses a significant t…
View article: LGALS3 promotes liver fibrosis by enhancing the expression and phosphorylation of ERK1/2
LGALS3 promotes liver fibrosis by enhancing the expression and phosphorylation of ERK1/2 Open
Background: Liver fibrosis represents the common endpoint of numerous chronic liver diseases. Current therapeutic approaches predominantly focus on alleviating symptoms or addressing the underlying causes, with limited options available fo…
View article: Breaking Performance Limits of Zn Anodes in Aqueous Batteries by Tailoring Anion and Cation Additives
Breaking Performance Limits of Zn Anodes in Aqueous Batteries by Tailoring Anion and Cation Additives Open
View article: Dressed bound states and non-Markovian dynamics with a whispering-gallery-mode microcavity coupled to a two-level atom and a semi-infinite photonic waveguide
Dressed bound states and non-Markovian dynamics with a whispering-gallery-mode microcavity coupled to a two-level atom and a semi-infinite photonic waveguide Open
We investigate the dressed bound states (DBS) in an open cavity with a whispering-gallery-mode microring coupled to a two-level atom and a waveguide with a mirror at the right end. We demonstrate that the non-Hermiticity of an open cavity …
View article: m6A modified BGN promotes the progression of melanoma via affecting the interaction between tumor cells and cancer-associated fibroblasts
m6A modified BGN promotes the progression of melanoma via affecting the interaction between tumor cells and cancer-associated fibroblasts Open
View article: Interfacial Engineering of LiNi0.83Co0.06Mn0.11O2 via Li2CO3 Coating: Synergistic Effects of Protective Layer and Surface Chemistry on Electrochemical Kinetics and Stability
Interfacial Engineering of LiNi0.83Co0.06Mn0.11O2 via Li2CO3 Coating: Synergistic Effects of Protective Layer and Surface Chemistry on Electrochemical Kinetics and Stability Open
View article: Manipulating spectral transitions and photonic transmission in a non-Hermitian optical system through nanoparticle perturbations
Manipulating spectral transitions and photonic transmission in a non-Hermitian optical system through nanoparticle perturbations Open
In recent years, extensive research has been dedicated to the study of parity-time ($\mathcal{PT}$) symmetry, which involves the engineered balance of gain and loss in non-Hermitian optics. Complementary to $\mathcal{PT}$ symmetry, the con…
View article: Identifying the mechanism of polysaccharopeptide against breast cancer based on network pharmacology and experimental verification
Identifying the mechanism of polysaccharopeptide against breast cancer based on network pharmacology and experimental verification Open
View article: The effect of antioxidant dietary supplements and diet-derived circulating antioxidants on vitiligo outcome: evidence from genetic association and comprehensive Mendelian randomization
The effect of antioxidant dietary supplements and diet-derived circulating antioxidants on vitiligo outcome: evidence from genetic association and comprehensive Mendelian randomization Open
Background Previous studies have indicated that antioxidant diets may have a positive impact on vitiligo by interfering with oxidative stress mechanisms. However, there has been a lack of research utilizing the Mendelian randomization (MR)…
View article: Effect of Artificial Aging Treatment on the Mechanical Properties and Regulation of Precipitated Phase Particles of High-Pressure Die-Cast Thin-Wall AlSi10MnMg Longitudinal Carrier
Effect of Artificial Aging Treatment on the Mechanical Properties and Regulation of Precipitated Phase Particles of High-Pressure Die-Cast Thin-Wall AlSi10MnMg Longitudinal Carrier Open
This study investigates the artificial aging treatment process for AlSi10MnMg longitudinal carriers with optimal strength and ductility. Experimental results illustrate that the peak strength is observed under single-stage aging at 180 °C …
View article: Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer
Costunolide-Induced Apoptosis via Promoting the Reactive Oxygen Species and Inhibiting AKT/GSK3β Pathway and Activating Autophagy in Gastric Cancer Open
Objective: Costunolide (Cos) is a sesquiterpene lactone extracted from chicory. Although it possesses anti-tumor effects, the underlying molecular mechanism against gastric cancer cells remains unclear. This study aimed to explore the effe…
View article: Thermosensitive and Conductive Hybrid Polymer for Real-Time Monitoring of Spheroid Growth and Drug Responses
Thermosensitive and Conductive Hybrid Polymer for Real-Time Monitoring of Spheroid Growth and Drug Responses Open
Three-dimensional (3D) cell culture based on polymer scaffold provides a promising tool to mimic a physiological microenvironment for drug testing; however, the next-generation cell activity monitoring technology for 3D cell culture is sti…
View article: Lotus seedpod-based carbon quantum dots: preparation, characterization and application for Fe(III) detection
Lotus seedpod-based carbon quantum dots: preparation, characterization and application for Fe(III) detection Open
Lotus seedpod (LS) was employed as a carbon source for the synthesis of carbon quantum dots (CQDs) using an economical and facile hydrothermal synthesis method.LS-CQDs were characterized with different techniques, including TEM, FTIR, PL, …
View article: Amorphization mechanism of SrIrO <sub>3</sub> electrocatalyst: How oxygen redox initiates ionic diffusion and structural reorganization
Amorphization mechanism of SrIrO <sub>3</sub> electrocatalyst: How oxygen redox initiates ionic diffusion and structural reorganization Open
The transformation from crystalline SrIrO 3 to active amorphous iridium oxide electrocatalyst occurs via the lattice oxygen redox.
View article: Research on mechanism of the effect of charred hawthorn on digestive by SCF /c-kit pathway
Research on mechanism of the effect of charred hawthorn on digestive by SCF /c-kit pathway Open
Background Hawthorn is the dry ripe fruit of Crataegus pinnatifida Bge in rose family which is a traditional Chinese medicine(TCM) for High-calorie-diet-induced dyspepsia (HC-DID). This study aimed to investigate whether the charred hawtho…
View article: The Improvement of Nanoemulsion Stability and Antioxidation via Protein-Chlorogenic Acid-Dextran Conjugates as Emulsifiers
The Improvement of Nanoemulsion Stability and Antioxidation via Protein-Chlorogenic Acid-Dextran Conjugates as Emulsifiers Open
In this experiment, the peanut protein isolate (PPI), soybean protein isolate (SPI), rice bran protein isolate (RBPI), and whey protein isolate (WPI) were modified by linking chlorogenic acid covalently and linking dextran by Maillard reac…
View article: Syntenin regulates melanogenesis via the p38 MAPK pathway
Syntenin regulates melanogenesis via the p38 MAPK pathway Open
Melanogenesis is the synthesis of the skin pigment melanin, which serves a critical role in the study of pigmentary skin diseases. Syntenin has been identified as a melanosome protein, but its role in melanogenesis is not completely unders…
View article: Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China
Optimizing diagnostic strategy for novel coronavirus pneumonia, a multi-center study in Eastern China Open
COVID-19 caused by a novel coronavirus SARS-CoV-2 emerged in Wuhan, Hubei province since December 2019, and caused a rapid outbreak throughout China and globally. Cities outside Hubei are also facing great challenge and require implementin…
View article: Redox Cycling Driven Transformation of Layered Manganese Oxides to Tunnel Structures
Redox Cycling Driven Transformation of Layered Manganese Oxides to Tunnel Structures Open
Mn oxides are among the most ubiquitous minerals on Earth and play critical roles in numerous elemental cycles in biotic/abiotic loops as the key redox center. Yet, it has long puzzled geochemists why the laboratory synthesis of todorokite…
View article: Investigation on heat-transfer-coefficient between aluminum alloy and organic/inorganic sand mold based on inverse method
Investigation on heat-transfer-coefficient between aluminum alloy and organic/inorganic sand mold based on inverse method Open
View article: Long non‑coding RNA00887 reduces the invasion and metastasis of non‑small cell lung cancer by causing the degradation of miRNAs
Long non‑coding RNA00887 reduces the invasion and metastasis of non‑small cell lung cancer by causing the degradation of miRNAs Open
Long non‑coding RNAs (lncRNAs) can act as carcinogenic or cancer suppressive factors during the pathogenesis, invasion and metastasis of non‑small cell lung cancer (NSCLC). The current study explored the role of long intergenic non‑protein…
View article: Low-temperature microstructural studies on superconducting CaFe2As2
Low-temperature microstructural studies on superconducting CaFe2As2 Open
View article: Highly Efficient Hydrogen Evolution from a Mesoporous Hybrid of Nickel Phosphide Nanoparticles Anchored on Cobalt Phosphosulfide/Phosphide Nanosheet Arrays
Highly Efficient Hydrogen Evolution from a Mesoporous Hybrid of Nickel Phosphide Nanoparticles Anchored on Cobalt Phosphosulfide/Phosphide Nanosheet Arrays Open
Facile design of low‐cost and high‐efficiency catalysts with earth‐abundant and cheap materials is desirable to replace platinum (Pt) for the hydrogen evolution reaction (HER) in water splitting, but the development of such HER catalysts w…
View article: Joint effect of magnesium and yttrium on enhancing thermoelectric properties of n-type Zintl Mg3+Y0.02Sb1.5Bi0.5
Joint effect of magnesium and yttrium on enhancing thermoelectric properties of n-type Zintl Mg3+Y0.02Sb1.5Bi0.5 Open
View article: Physicochemical Properties and Storage Stability of Food Protein-Stabilized Nanoemulsions
Physicochemical Properties and Storage Stability of Food Protein-Stabilized Nanoemulsions Open
This study investigated the preparation and properties of corn oil nanoemulsions stabilized by peanut protein isolate (PPI), rice bran protein isolate (RBPI), soybean protein isolate (SPI), and whey protein isolate (WPI). The mean droplet …
View article: H1N1 influenza virus epitopes classified by monoclonal antibodies
H1N1 influenza virus epitopes classified by monoclonal antibodies Open
Epitopes serve an important role in influenza infection. It may be useful to screen universal influenza virus vaccines, analyzing the epitopes of multiple subtypes of the hemagglutinin (HA) protein. A total of 40 monoclonal antibodi…
View article: High-performance bifunctional porous non-noble metal phosphide catalyst for overall water splitting
High-performance bifunctional porous non-noble metal phosphide catalyst for overall water splitting Open
View article: Effect of Zn coprecipitation on the structure of layered Mn oxides
Effect of Zn coprecipitation on the structure of layered Mn oxides Open