Jiayun Huang
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View article: Elastin-derived extracellular matrix fragments drive aging through innate immune activation
Elastin-derived extracellular matrix fragments drive aging through innate immune activation Open
The roles of cells in systemic aging have been systematically investigated, while the roles of the extracellular matrix (ECM) and its degradation have been largely overlooked. Herein, we show that the serum contents of elastin-, hyaluronic…
View article: Dynamic changes of molecular pattern and cellular subpopulation in puncture-induced tendon injury model
Dynamic changes of molecular pattern and cellular subpopulation in puncture-induced tendon injury model Open
View article: Biomimetic Intrafibrillar Mineralization of Native Tendon for Soft–Hard Interface Integration by Infiltration of Amorphous Calcium Phosphate Precursors
Biomimetic Intrafibrillar Mineralization of Native Tendon for Soft–Hard Interface Integration by Infiltration of Amorphous Calcium Phosphate Precursors Open
Soft and hard tissues possess distinct biological properties. Integrating the soft‐hard interface is difficult due to the inherent non‐osteogenesis of soft tissue, especially of anterior cruciate ligament and rotator cuff reconstruction. T…
View article: Challenges of 'imaging' particulate materials in three dimensions
Challenges of 'imaging' particulate materials in three dimensions Open
In this perspective article, we discuss the challenges of imaging assemblies of particles in three dimensions. Starting from a brief motivation for the investigation of particulate materials, we provide an overview of experimental approach…
View article: Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization
Promoting musculoskeletal system soft tissue regeneration by biomaterial-mediated modulation of macrophage polarization Open
View article: An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem Cells
An Off-the-Shelf Tissue Engineered Cartilage Composed of Optimally Sized Pellets of Cartilage Progenitor/Stem Cells Open
Articular cartilage focal lesion remains an intractable challenge in sports medicine, and autologous chondrocytes' implantation (ACI) is one of the most commonly utilized treatment modality for this ailment. However, the current ACI techni…
View article: Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification
Targeted pathological collagen delivery of sustained-release rapamycin to prevent heterotopic ossification Open
We revealed the importance of mTOR in tendon HO and established a drug delivery system that targets pathological collagen.
View article: Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages
Characterization and Comparison of Postnatal Rat Meniscus Stem Cells at Different Developmental Stages Open
Meniscus-derived stem cells (MeSCs) are a potential cell source for meniscus tissue engineering. The stark morphological and structural changes of meniscus tissue during development indicate the complexity of MeSCs at different tissue regi…
View article: Knitted Silk-Collagen Scaffold Incorporated with Ligament Stem/Progenitor Cells Sheet for Anterior Cruciate Ligament Reconstruction and Osteoarthritis Prevention
Knitted Silk-Collagen Scaffold Incorporated with Ligament Stem/Progenitor Cells Sheet for Anterior Cruciate Ligament Reconstruction and Osteoarthritis Prevention Open
Current surgical management of anterior cruciate ligament (ACL) rupture still remains an intractable challenge in ACL regeneration due to the weak self-healing capability of ACL. Inadequate cell numbers and vascularization within the artic…
View article: The Plasticity of Mesenchymal Stem Cells in Regulating Surface HLA-I
The Plasticity of Mesenchymal Stem Cells in Regulating Surface HLA-I Open
View article: The relationship between substrate topography and stem cell differentiation in the musculoskeletal system
The relationship between substrate topography and stem cell differentiation in the musculoskeletal system Open
View article: The roles of inflammatory mediators and immunocytes in tendinopathy
The roles of inflammatory mediators and immunocytes in tendinopathy Open
View article: Exogenous stromal derived factor-1 releasing silk scaffold combined with intra-articular injection of progenitor cells promotes bone-ligament-bone regeneration
Exogenous stromal derived factor-1 releasing silk scaffold combined with intra-articular injection of progenitor cells promotes bone-ligament-bone regeneration Open
View article: Ectopic tissue engineered ligament with silk collagen scaffold for ACL regeneration: A preliminary study
Ectopic tissue engineered ligament with silk collagen scaffold for ACL regeneration: A preliminary study Open
View article: Alignment of collagen fiber in knitted silk scaffold for functional massive rotator cuff repair
Alignment of collagen fiber in knitted silk scaffold for functional massive rotator cuff repair Open