Fang Jingyuan
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View article: Binding of <i>Fusobacterium nucleatum</i> autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion
Binding of <i>Fusobacterium nucleatum</i> autotransporter adhesin CbpF to human CEACAM1 and CEACAM5: A Velcro model for bacterium adhesion Open
In eukaryotic systems, three major types of cell junctions have been well characterized. While bacterial adhesion mechanisms also exhibit remarkable diversity, the molecular processes that regulate the dynamic modulation of binding strengt…
View article: Clinicopathological Characteristics of Gastric Cancer in China: A 16‐Year Single‐Center Retrospective Clinical Study
Clinicopathological Characteristics of Gastric Cancer in China: A 16‐Year Single‐Center Retrospective Clinical Study Open
Objectives Factors such as Helicobacter pylori eradication and the implementation of widespread early cancer screening have significantly influenced clinicopathological features and patient outcomes in gastric cancer (GC) in China. We aime…
View article: Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells
Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells Open
BACKGROUND: Myocardial infarction (MI) is a high-prevalence disease that threatens human survival and quality of life worldwide. Considerable evidence has suggested that periodontitis (PD) is detrimental to MI. However, the direct impact o…
View article: Microbiota targets in immune checkpoint therapy: How far are we from clinical application?
Microbiota targets in immune checkpoint therapy: How far are we from clinical application? Open
View article: Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case–Control Study in China
Risk Factors Analysis and Predictive Model Construction for Autoimmune Gastritis: A Nationwide Multicenter Case–Control Study in China Open
Objective Here, we ascertained the clinical characteristics of Chinese patients with autoimmune gastritis (AIG) and determined the correlation of dietary and lifestyle factors with AIG occurrence and development to establish a noninvasive …
View article: Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer Open
View article: Association Between Biologics and Janus Kinase Inhibitors With Inflammatory Bowel Disease as Paradoxical Reactions: A Real‐World Assessment
Association Between Biologics and Janus Kinase Inhibitors With Inflammatory Bowel Disease as Paradoxical Reactions: A Real‐World Assessment Open
Background and Objective With limited evidence connecting paradoxical inflammatory bowel disease (paradoxical IBD) to the newest biologics and Janus kinase inhibitors, our study aims to investigate the occurrence of paradoxical IBD induced…
View article: Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer Open
Microsatellite stable (MSS) colorectal cancers (CRCs) are often resistant to anti-programmed death-1 (PD-1) therapy. Here, we show that a CRC pathogen, Fusobacterium nucleatum (Fn), paradoxically sensitizes MSS CRC to anti-PD-1. Fecal micr…
View article: Issue Information
Issue Information Open
ng global guidelines and best prac� ces for paper use, establishing a vendor code of ethics, and engaging our colleagues and other stakeholders in our eff orts.
View article: NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition
NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition Open
Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment. Here, cancer cell lines sensitive or…
View article: Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker?
Histologically proven AMA positive primary biliary cholangitis but normal serum alkaline phosphatase: Is alkaline phosphatase truly a surrogate marker? Open
In patients who were AMA-positive but had normal ALP levels, more than 80% were associated with histological classic PBC. These data emphasize the importance of a positive AMA, even with a normal ALP and also question the role of ALP as a …
View article: Upregulation of <scp>ASAP</scp>3 contributes to colorectal carcinogenesis and indicates poor survival outcome
Upregulation of <span>ASAP</span>3 contributes to colorectal carcinogenesis and indicates poor survival outcome Open
The function and clinical implication of Arf GAP with SH 3 domain, ankyrin repeat, and PH domain 3 ( ASAP 3) in colorectal cancer ( CRC ) remains undefined. In the present study, we showed that the expression level of ASAP 3 was dramatical…
View article: The role of RUNX1 in LRG1-induced cell proliferation and anti-apoptosis.
The role of RUNX1 in LRG1-induced cell proliferation and anti-apoptosis. Open
(a) RUNX1 expression was knocked down in siRNA-transfected SW480 cells at both the mRNA and protein levels. (b) SW480 cells were transfected with RUNX1 or control siRNA with or without rLRG1 (500 ng/ml) stimulation, and a CCK…
View article: The knockdown of LRG1 inhibited CRC cell proliferation and induced cell cycle arrest.
The knockdown of LRG1 inhibited CRC cell proliferation and induced cell cycle arrest. Open
(a) RT-PCR and Western blot analyses showed that LRG1 was effectively down-regulated by siRNA transfection. (b) A CCK-8 assay was performed to evaluate cell proliferation in vitro. (c-d) SW480 and HCT116 cells were fix…
View article: The knockdown of LRG1 promoted CRC cell apoptosis.
The knockdown of LRG1 promoted CRC cell apoptosis. Open
(a-b) SW480 and HCT116 cells were double stained with an FITC-conjugated anti-Annexin V antibody and PI and then subjected to flow cytometry for cell apoptosis analysis. The cells in the upper right and lower right quadrants were co…
View article: LRG1 promoted the expression of RUNX1 and CRC cell proliferation.
LRG1 promoted the expression of RUNX1 and CRC cell proliferation. Open
(a) SW480 and HCT116 cells were transfection with LRG1 siRNA, and the expression of the tested RUNXs was quantified by RT-PCR. (b) Cells were stimulated with rLRG1 (0–1,000 ng/ml) for 24 h, and the RUNX1 expression was determ…
View article: Knockdown of TRAPPC4 decreased actived ERK1/2 level in nucleus on SW1116 cell line.
Knockdown of TRAPPC4 decreased actived ERK1/2 level in nucleus on SW1116 cell line. Open
SW1116 cells were transfected with TRAPPC4 siRNA (siTRAPPC4) to knockdown TRAPPC4 expression or with Negtive Control siRNA (siControl) as control; Also cells were treated with PDGF to activate ERK-MAPK pathway, or with its solvent (PBS+0.1…
View article: Gut Microbiota and Colorectal Cancer
Gut Microbiota and Colorectal Cancer Open
Background: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide whose incidence has increased rapidly in recent years. There is growing evidence that the complex gut microbiota community plays an …